The exocrine pancreas / Stephen J. Pandol.

Format:

Book

Author/Creator:

Pandol, Stephen J.

Series:

Colloquium series on integrated systems physiology ; #14.

Integrated systems physiology : from molecule to function to disease, 2154-560X ; bk. #14

Language:

English

Subjects (All):

Pancreas.

Pancreatic acinar cells.

Physical Description:

1 online resource (65 p.)

Place of Publication:

[San Rafael, Calif.?] : Morgan & Claypool Life Sciences, 2011.

Language Note:

English

Summary:

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Contents:

Introduction

Anatomy

Gross anatomic considerations

Functional anatomic considerations

Pancreatic embryology and development

Digestive enzymes

Digestive enzymes synthesis and transport

Environmental and genetic stressors and the secretory pathway

Exocrine pancreatic UPR adaptive response

Environmental stress and diseases of the exocrine pancreas

Digestive enzymes and their functions

Regulation of digestive enzyme synthesis

Stimulation of digestive enzyme secretion from the acinar cell

Water and ion secretion from the pancreatic ductal system

Flow and ion concentrations of pancreatic fluid

Regulation of ion transporters of the pancreatic duct cell

Regulation of whole-organ pancreatic secretion

Interdigestive secretion

Digestive secretion

Intestinal luminal sensors involved in pancreatic secretion

Feedback regulation of pancreatic secretion

Measurement of exocrine pancreatic secretion in humans

Clinical application of knowledge of pancreatic physiology

Summary

Reference.

Notes:

Part of: Colloquium digital library of life sciences.

Series from website.

Title from PDF t.p. (viewed on April 21, 2011).

Includes bibliographical references.

Cited in:

Google scholar

Google book search

ISBN:

1-61504-139-7

OCLC:

708084265