Molecular pathology of Alzheimer's disease / Rudy J. Castellani, George Perry.

Format:

Book

Author/Creator:

Castellani, Rudy J., author.

Perry, George., author.

Series:

Colloquium series on neurobiology of Alzheimer's disease ; # 1.

Colloquium digital library of life sciences.

Colloquium series on neurobiology of Alzheimer's disease ; # 1

Language:

English

Subjects (All):

Alzheimer Disease--physiopathology.

Alzheimer's disease--Pathophysiology.

Alzheimer's disease.

Medical Subjects:

Alzheimer Disease--physiopathology.

Physical Description:

1 online resource (93 p.)

Place of Publication:

San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014.

Language Note:

English

System Details:

Mode of access: World Wide Web.

Summary:

Alzheimer's Disease is characterized pathologically by two principal hallmark lesions, the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-[beta] production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer's Disease, relied upon in the diagnostic criteria for Alzheimer's Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer's Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Contents:

5. Synopsis and conclusions

References

Author biographies.

4. Complexities

4.1 Regional distribution of plaques and tangles

4.2 Oligomers

4.3 The synapse

4.4 Clinicopathologic correlations

4.5 Pathological criteria for autopsy diagnosis

4.5.1 Khachaturian criteria

4.5.2 Braak staging

4.5.3 CERAD (Consortium to Establish a Registry for Alzheimer's Disease) guidelines

4.5.4 NIA-Reagan criteria

4.5.5 Criteria

3. Neurofibrillary degeneration

3.1 Pathology

3.2 Purification of tau

3.3 Tau biology

3.4 Granulovacuolar degeneration

2. Plaques

2.1 Pathology

2.2 The purification of amyloid

2.3 Amyloid-[beta] protein precursor

2.4 Secretases

2.4.1 BACE-1

2.4.2 [gamma]-secretase

2.4.3 [alpha]-secretase

2.5 Summary of ABPP processing

2.6 Implications of familial AD in the molecular pathology

1. Introduction

Notes:

Series from website.

Part of: Colloquium digital library of life sciences.

Includes bibliographical references (pages 65-81).

Title from PDF title page (viewed on November 14, 2013).

Cited in:

Google book search

Google scholar

ISBN:

1-61504-639-9

OCLC:

862614255