Precision Molecular Pathology of Aggressive B-Cell Lymphomas / edited by Genevieve M. Crane, Sanam Loghavi.

Format:

Book

Contributor:

Crane, Genevieve M., editor.

Loghavi, Sanam, editor.

Series:

Molecular Pathology Library, 1935-9888

Language:

English

Subjects (All):

Pathology.

Internal medicine.

Internal Medicine.

Local Subjects:

Pathology.

Internal Medicine.

Physical Description:

1 online resource (433 pages)

Edition:

1st ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2023.

Summary:

Written by experts in the field, Precision Molecular Pathology of Aggressive B-Cell Lymphomas contains the most recent revisions from the 5th Edition WHO and 2022 International Consensus Classification diagnostic categories and serves as an important resource for trainees, pathologists, haematologist/oncologists, other clinicians involved in lymphoma care and lymphoma researchers. It provides a comprehensive yet concise synthesis of emerging molecular advances that inform patient care and improve understanding of disease mechanisms. In addition, it provides the necessary background to how molecular techniques are performed to enable the reader to better interpret and critically evaluate relevant and emerging data. As part of the Molecular Pathology Library series, this book focuses specifically on aggressive B-cell lymphomas given the increasing relevance of molecular data for diagnosis and treatment of these disorders. This evidence-based text contains 25 chapters and is divided into 5 parts. Part 1 provides a brief history and background of aggressive B-cell lymphomas. Landmark events in their classification and treatment are given in order to place the substantial advances in the field in context. Part 2 reviews molecular pathology methods, including the increasing use of next generation sequencing techniques in clinical practice. Parts 3 and 4 focus on individual subtypes of aggressive B-cell lymphoma, including a summary of the diagnostic criteria and key pathologic and clinical features for each entity. Finally, Part 5 focuses on emerging molecular technologies that may significantly impact clinical practice. .

Contents:

Section I. Background

Historical Perspectives in B-Cell Lymphoma Classification: From Hodgkin to WHO

Revisions to the Classification of Aggressive B-Cell Lymphomas

Section II. Methods

Cytogenetics and FISH in Precision Molecular Pathology of Aggressive B-Cell Lymphomas

Introduction to Next Generation Sequencing

Next Generation Sequencing-Based Methods for the Detection of B-Cell Clonality

Next Generation Sequencing Detection of Copy Number Variants and Translocations

RNA-Seq and RNA Expression Profiling

Flow Cytometry Applications in the Diagnosis and Classification of Aggressive B-Cell Lymphoma

Section III. Molecular Characteristics of Specific Large B-Cell Lymphoma Subtypes

High-Grade B-Cell Lymphomas

Precision Medicine in Burkitt and Burkitt-Like Lymphomas

Precision Medicine in Diffuse Large B-Cell Lymphoma

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma

Special Sites: Primary Mediastinal Large B-Cell Lymphoma, Primary CNS Diffuse Large B-Cell Lymphoma, and Primary Testicular Diffuse Large B-Cell Lymphoma

Molecular Pathology of Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Lymphomatoid Granulomatosis

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

ALK Positive Large B-Cell Lymphoma

HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified / KSHV/HHV8-Positive Diffuse Large B-Cell Lymphoma

Large B-Cell Lymphomas With IRF4 Rearrangements

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation and Fibrin-Associated Large B-Cell Lymphoma

Section IV. Immune Deficiency Related Lymphoproliferative Disease

Plasmablastic Lymphoma

Genetic Landscape of Post-Transplant Lymphoproliferative Disorders

Epstein-Barr Virus-Positive Mucocutaneous Ulcer

Section V. Emerging Molecular Technologies

Circulating Tumor DNA in Lymphoma.

Notes:

Includes bibliographical references and index.

ISBN:

3-031-46842-2