Guidance Document on the Androgenised Female Stickleback Screen / OECD.

Format:

Book

Author/Creator:

Organisation for Economic Co-operation and Development, author, issuing body.

Series:

OECD environmental health and safety publications. Series on testing and assessment.

OECD Series on Testing and Assessment

Language:

English

Subjects (All):

Antiandrogens.

Endocrine disrupting chemicals.

Physical Description:

1 online resource (47 pages).

Place of Publication:

Paris : OECD Publishing, 2017.

Summary:

This guidance document describes an in vivo screening assay where sexually mature female sticklebacks are exposed to suspected anti-androgenic chemicals during a limited part of their life-cycle (21 days). The AFFS can detect both androgens and anti-androgens; however its usefulness is greater in the detection of androgen antagonists. The protocol does not require an in situ pre-exposure period and measures one biomarker endpoint as indicator of (anti)androgenic activity, the level of spiggin in the female stickleback kidneys. Other measurements include survival and body weight; these are not considered endpoints in the AFSS but are needed to confirm statistical robustness of the assay (survival) and biomarker level (spiggin/g body weight).

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

92-64-98100-4