Guidance Document on Inhalation Toxicity Studies / OECD.

Format:

Book

Author/Creator:

Organisation for Economic Co-operation and Development, author, issuing body.

Series:

OECD environmental health and safety publications. Series on testing and assessment.

OECD Series on Testing and Assessment

Language:

English

Subjects (All):

Gases, Asphyxiating and poisonous--Toxicity testing.

Gases, Asphyxiating and poisonous.

Physical Description:

1 online resource (106 pages).

Edition:

Second edition.

Place of Publication:

Paris : OECD Publishing, 2018.

Summary:

The main purpose of this document is to assist the regulated community and regulators in selecting the most appropriate acute inhalation TG so that particular data requirements can be met while reducing animal usage and suffering. This Guidance Document also contains additional supporting information on the conduct and interpretation of studies performed using the inhalation test guidelines: TG 403, TG 436, TG 433, TG 412, and TG 413. As mentioned before, for a number of Test Guidelines, such as TG 451 (carcinogenicity), TG 452 (chronic toxicity) or the Test Guidelines on reproduction and neurologic endpoints, the inhalation route of exposure may be used but this is not mentioned specifically in the guidance. If the inhalation route is chosen, the present guidance document should be consulted in the design of the studies. The second purpose of this document is to provide the necessary guidance when testing nanomaterials via inhalation in the 28-d and 90-d toxicity studies, subsequent to the high priority activity undertaken at the OECD.

Contents:

FOREWORD

1. INTRODUCTION

2. PURPOSE

3. DATA NEEDS

4. ACUTE TEST GUIDELINE SELECTION

5. CONDUCT OF INHALATION STUDIES

6. MONITORING OF EXPOSURE CONDITIONS

7. OBSERVATIONS OF ANIMALS

8. STATISTICAL ANALYSIS OF DATA

9. REFERENCES

APPENDIX I. ABBREVIATION, ACRONYMS AND GLOSSARY

APPENDIX II. GHS CLASSIFICATION SYSTEM FOR ACUTE INHALATION (LC50)

APPENDIX III. COMPARISON OF ACUTE TEST GUIDELINES

APPENDIX IV. PARTICLE SIZE

APPENDIX VI. INSTILLATION AND ASPIRATION STUDIES.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

92-64-77397-5