Insights Into Treg Cell Biology From Infection and Homeostasis Zachary R Lanzar

Format:

Book

Thesis/Dissertation

Author/Creator:

Lanzar, Zachary R., author.

Contributor:

University of Pennsylvania. Immunology., degree granting institution.

Language:

English

Subjects (All):

0307.

0379.

0571.

0982.

Local Subjects:

0307.

0379.

0571.

0982.

Physical Description:

1 electronic resource (187 pages)

Contained In:

Dissertations Abstracts International 87-07B

Place of Publication:

Ann Arbor : ProQuest Dissertations and Theses, 2025

Language Note:

English

Summary:

Foxp3+ regulatory T cells (Treg) are a specialized T cell subset that enforce peripheral tolerance and temper many types of inflammatory processes. Since their initial description there has been an interest in understanding how these regulatory cells influence the outcome of infection. Multiple studies have shown that the role of Treg cells during diverse infections is context dependent: certain challenges can lead to increased Treg cell functions that limit infection-induced pathology or promote pathogen replication. In contrast, some host responses results in loss of Treg cells that allow the expansion of effector T cell populations while there are also microbial strategies to promote Treg cell activity as a mechanism of immune evasion. Here, we conducted studies to investigate the role of various cytokine signaling axis on Treg cell biology during infection and homeostasis and highlight how these studies have provided fundamental insights into Treg biology

Notes:

Advisors: Hunter, Christopher A. Committee members: Silverman, Michael; Jordan, Martha; Oliver, Paula; Cancro, Michael

Includes supplementary digital materials

Source: Dissertations Abstracts International, Volume: 87-07, Section: B.

Ph.D. University of Pennsylvania 2025

Vendor supplied data

Local Notes:

School code: 0175

ISBN:

9798276006390

Access Restriction:

Restricted for use by site license