The chemistry of coumarin / Scott R. Sheley.

Format:

Book

Author/Creator:

Sheley, Scott R., author.

Series:

Chemistry research and applications series.

Chemistry research and applications

Language:

English

Subjects (All):

Coumarins.

Physical Description:

1 online resource (136 pages)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, [2023]

Summary:

This book reviews and examines the chemistry of coumarin from different perspectives in six chapters. Chapter One reviews the one-pot synthesis of bromocoumarins via consecutive Pechmann condensation and bromination catalyzed by cellulose sulfuric acid. Chapter Two examines recent advances in heterocyclic compounds. Chapter Three looks at the chemical constituents and synthetic methods of bioactive coumarins. Chapter Four provides insights into the structure-activity relationship of alkylnyl-coumarinyl ethers as selective mao-B inhibitors using molecular docking. Chapter Five reviews the phytochemistry and pharmacological actions of coumarin. Chapter Six is an overview of coumarins from different perspectives.

Contents:

Intro

Contents

Preface

Chapter 1

One-Pot Synthesis of Bromocoumarins via Consecutive Pechmann Condensation and Bromination Catalyzed by Cellulose Sulfuric Acid

Abstract

Introduction

Results and Discussion

Summary

Experimental

Synthesis

Materials and Methods

References

Chapter 2

Recent Advances of Heterocylic Compounds

Literature Review

Classification of Coumarin

Coumarin Drugs Are Commercially Available

Synthetic Approaches of Coumarins

Coumarin Synthesis from Aldehyde

Coumarin Synthesis from Phenols

Coumarin Synthesis from Ketones

Biological Potential of Coumarin Analogs

Conclusion

Chapter 3

Chemical Constituents and Synthetic Methods of Bioactive Coumarins

Abbrevations

1. Introduction

1.1. Sources of Coumarins

1.2. Application and Progress of Coumarins

2. Structural Types of Coumarins

2.1. Simple Coumarins

2.2. Furancoumarins

2.3. Pyranocoumarins

2.4. Other Coumarins

3. Extraction and Separation of Coumarins

3.1. Extraction Ways

3.1.1. Solvent Extraction

3.1.2. Acid-Base Method

3.1.3. Steam Distillation

3.1.4. Supercritical Fluid Extraction Technology

3.2. Separation Ways

3.2.1. Crystallization

3.2.2. Extraction Method

3.2.3. Acid-Base Treatment

3.2.4. Separation

4. Physical and Chemical Properties of Coumarins

4.1. Dissolution and Fluorescence Properties

4.2. Properties of Lactone

4.3. Oxidation Reaction

4.4. Substitution Reactions

5. Synthesis of Coumarins

5.1. Total Synthesis of Coumarins

5.1.1. Perkin Synthesis Method

5.1.2. Pechmann Synthesis

5.1.3. Wittig Synthesis

5.1.4. Knoevenagel Synthesis

5.1.5. Remier-Tiemalni Synthesis

5.1.6. Sodium Chloroacetate Synthesis

5.1.7. Vilsmeier-Haack Synthesis.

5.2. Synthesis of Coumarin Derivatives

5.2.1. Modification on Coumarins at C-3 Position

5.2.2. Modification on Coumarins at C-4 Position

5.2.3. Modification on Coumarins at C-6 Position

5.2.4. Modification on Coumarins at C-7 Position

5.2.5. Modification on Coumarins at C-8 Position

5.3. Biosynthesis of Coumarins

5.3.1. Biosynthesis of Simple Coumarins

5.3.2. Biosynthesis of Furanocoumarins

6. Bioactivities of Coumarins

6.1. Anticancer Activity

6.2. Antibacterial Activity

6.3. Antioxidant Activity

6.4. Antiviral and Anti-HIV Activity

6.5. Coumarin in the Treatment of Diabetes

6.6. Insecticidal Activity

Conclusion and Prospects

Chapter 4

Insights into the Structure-Activity Relationship of Alkynyl-Coumarinyl Ethers as Selective MAO-B Inhibitors Using Molecular Docking

Protein Preparation

Chemical Structures Preparation

Molecular Docking

Results

Molecular Docking Results

Structure-Activity Relationship Analysis

Discussion

Disclaimer

Chapter 5

Phytochemistry and Pharmacological Actions of Coumarin

1. Occurrence, Distribution, Chemistry, Classification and Biosynthetic Pathway of Coumarins

Occurrence

Distribution

Chemistry

Classification

Biosynthesis

2. Pharmacological Actions of Coumarin

Anti-Oxidant Action

Anti-Inflammatory Action

Anticancer Action

Anti-Diabetic and Hypolipidemic Action

Anticoagulant Action

Neuroprotective Action

Antimicrobial Action

Chapter 6

An Overview of Coumarins: Pharmacognosy, Phytochemistry and Structural Activity Relationship (SAR)

Coumarins in Medicinal Plants

SAR of Coumarin

SAR for Anti-Inflammatory Action of Coumarin.

SAR for Antiepileptic Action of Coumarins

SAR for Anti-Neurodegenerative Properties Coumarins

SAR for Anticoagulant Properties Coumarins

SAR for Anticancer Activity of Coumarins

SAR for Metabolic Modulation by Coumarins

SAR for Antimicrobial Actions of Coumarins

Declarations

Index

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Blank Page.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Sheley, Scott R. The Chemistry of Coumarin

ISBN:

9798886975970