Comprehensive medicinal chemistry

Format:

Book

Contributor:

Rotella, David P., editor.

Ward, Simon E. (Simon Edward), editor.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Chemistry, Pharmaceutical.

Medical Subjects:

Chemistry, Pharmaceutical.

Physical Description:

1 online resource

Edition:

Fourth edition editor in chief, David P. Rotella, Simon E. Ward

Place of Publication:

Amsterdam : Elsevier, [2026]

System Details:

digital

Summary:

Comprehensive Medicinal Chemistry, Fourth Edition, Four Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. A list of new areas covered includes: - newer assays, techniques, applications in medicinal chemistry - use of artificial intelligence and machine learning in drug discovery and development (prediction of drug efficacy, toxicity, and ADME properties, identification of new drug targets; design of novel drug candidates) - big data - chemical biology - degradation technologies - Precision medicine (targeted therapies; the use of biomarkers to guide drug development).

Contents:

Volume 1. General perspective - the future of drug discovery / section editors, Thomas R. Simpson, Mark C. Noe

Experimental advances in medicinal chemistry

Volume 2. Drug discovery technologies : in silico drug discovery tools / section editors, Andrew M. Davis, Darren Vs Green

Volume 3. Biologics medicine

Drug target in medicinal chemistry / section editors, Yasmina Noubia Abdiche, David Uehling, Laszlo E. Kiss

Volume 4. Cancer

Drug target in medicinal chemistry / section editors, Ian Collins, Bernard Barlaam, Daniele Andreotti

Notes:

Includes bibliographical references and index

Online resource; title from PDF title page of volume 1 (ScienceDirect, viewed June 5, 2026)

Other Format:

Print version Comprehensive medicinal chemistry

ISBN:

9780443298097

0443298092

OCLC:

1589430022

Access Restriction:

Restricted for use by site license