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Esophageal disease and the role of the microbiome / edited by David A. Johnson.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Esophagus--Diseases.
- Esophagus.
- Medical microbiology.
- Esophageal Diseases.
- Gastrointestinal Microbiome.
- Microbiota.
- Medical Subjects:
- Esophageal Diseases.
- Gastrointestinal Microbiome.
- Microbiota.
- Esophagus.
- Physical Description:
- 1 online resource (216 pages)
- Place of Publication:
- London, England : Academic Press, [2023]
- Summary:
- Esophageal Diseases and the Role of the Microbiome provides evidence on biomic influence in esophageal diseases. The book builds on the translational information on H pylori for ulcer disease as well as the explosive focus on biomic influence in virtually all areas of esophageal diseases. This important reference will help translational researchers by providing scientific understanding and hypothesis generation that is needed for furthering this field of study. It will also provide clinicians with disease management options for esophageal diseases (for GERD and PPI options/side effects) and present cutting-edge science to promote provider/patient understanding and options.
- Contents:
- Intro
- Esophageal Disease and the Role of the Microbiome
- Copyright
- Contents
- Contributors
- Introduction
- Chapter 1: Is acid the cornerstone factor in gastroesophageal reflux disease and its related complications?
- Introduction-A brief history of gastric acid
- Evidence that acid causes esophageal injury
- Acid and heartburn
- Bile acids, esophageal injury, and heartburn
- Conclusions
- Future directions
- Conflict of interest disclosures
- References
- Chapter 2: Cytokines and immune modulators-Effects on esophageal inflammation
- Esophageal mucosal defense systems
- Immune-mediated response in animal models and humans with acute reflux esophagitis
- Cytokines: Initiators of the immune-mediated response in acute reflux esophagitis
- Cytokines: Initiators of epithelial repair responses in acute reflux esophagitis
- Cytokines: Potential disruptors of the physical epithelial barrier in acute reflux esophagitis
- Hypoxia-inducible factor-2α: Central role in the squamous cell cytokine response in acute reflux esophagitis
- Role of the immune system in reflux esophagitis
- Esophageal innate immunity and toll-like receptors
- Activation of the innate immune system during reflux esophagitis
- TLR2 signaling in esophageal squamous mucosa
- TLR4 signaling in esophageal squamous mucosa
- Esophageal adaptive immunity and T cell phenotypes
- COI disclosures
- Chapter 3: Acid suppression and effects on the gastrointestinal microbiome
- Animal studies
- Human studies
- Salivary microbiome
- Esophageal microbiome
- Gastric microbiome
- Small and large bowel
- Fecal microbiome studies
- Limitations of currently available data
- Disease associations
- Summary
- Future priorities
- References.
- Chapter 4: Esophageal dysbiosis and pathogenesis of gastroesophageal reflux disease
- Traditional view of GERD progression
- Anatomic factors
- Nonanatomic factors
- Revised mechanism for GERD pathogenesis
- Microbiome changes
- Overall composition
- Microgeographic changes
- Biofilm
- Intestinal microbiome
- Inflammatory pathway
- Author contributions
- Chapter 5: Gastroesophageal reflux disease and the role of Helicobacter pylori
- Pathogenesis of GERD
- Biologic links/plausibility
- Epidemiology/outcomes
- Conflict of interest disclosure
- Chapter 6: Esophageal dysbiosis and neoplasia: Moving from Barrett's esophagus to adenocarcinoma
- Development of microbiome research contributes to a new concept of health and disease
- Risk and environmental factors altering the risk of EAC-progression
- Microbial alterations in the esophagus linked to histopathological changes
- Microbes influencing BE- and EAC-pathogenesis
- Esophageal microbiome: current techniques of sampling and analysis need to be improved
- Conclusion
- Chapter 7: Esophageal dysbiosis and esophageal squamous cell carcinoma
- Esophageal dysbiosis in Esophageal squamous cell carcinoma
- P. gingivalis
- F. nucleatum
- Esophageal microbiome: Environmental exposures and carcinogen metabolism
- Oral microbiome, Oral health, and Esophageal squamous cell carcinoma
- Role of the gastric microenvironment in Esophageal squamous cell carcinoma
- Limitations of current research
- Chapter 8: Esophageal dysbiosis and eosinophilic esophagitis-Bacteria to blame?
- Introduction.
- Normal esophageal microbiome
- Potential modulators of the Esophageal microbiome in eosinophilic esophagitis
- Sampling methods used to study the microbiome in EoE
- EoE microbiome
- Data summary and pathophysiologic significance
- COI
- Chapter 9: Laryngopharyngeal reflux and dysbiosis
- Introduction-The gut microbiota and its influence
- Mechanisms for defense against laryngopharyngeal reflux
- Diagnosis of LPR
- Lifestyle factors
- Hypersensitivity
- Acid and nonacid esophageal reflux
- Esophageal and gastric adenocarcinoma
- Microbiota and bacterial overgrowth
- Treatment and proton pump inhibitors
- COI and disclosures
- Chapter 10: Esophageal dysbiosis and esophageal motility disorders
- Achalasia
- Chagas disease and megaesophagus
- Squamous cell carcinoma (SCC) in the setting of achalasia
- Esophageal hypermotility disorders
- Esophageal hypomotility disorders
- Future research
- Conflicts of interest
- Chapter 11: Gastrointestinal microbiome: Evaluation of testing technologies
- Bacteria in the foregut: From assumed sterility to the exploration of complex microbial communities
- Culture-dependent identification of microbial communities
- Culture-independent methods of studying the microbiome
- Sampling and nucleic acid isolation
- Capturing the microbial genome
- Chapter 12: Esophagogastric microbiome-Internal and external influences effecting variance
- Internal factors (Fig. 1)
- Age
- Oral and dental health
- Obesity
- External factors (Fig. 2)
- Diet
- Antibiotics
- Prebiotics and probiotics
- Proton pump inhibitors
- Tobacco and alcohol
- Conclusions.
- Future directions
- Conflict of interest
- Chapter 13: Esophageal dysbiosis-Correcting the paradox: Prebiotics, probiotics, or antibiotics?
- Prebiotics
- Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC)
- Eosinophilic esophagitis (EoE)
- Limitations to the use and study of prebiotics
- Probiotics
- Gastroesophageal reflux disease
- Barrett's esophagus
- Cancer
- Candidiasis
- Eosinophilic esophagitis
- Bacteriocins
- Index.
- Notes:
- Includes bibliographical references and index.
- Description based on print version record.
- Other Format:
- Print version: Johnson, David A. Esophageal Disease and the Role of the Microbiome
- ISBN:
- 9780323950718
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