Surface enhanced Raman spectroscopy : biosensing and diagnostic technique for healthcare applications / edited by Swati Jain and Sruti Chattopadhyay.

Format:

Book

Contributor:

Jain, Swati, editor.

Chattopadhyay, Sruti, editor.

Language:

English

Subjects (All):

Raman spectroscopy.

Physical Description:

1 online resource (263 pages)

Edition:

1st ed.

Place of Publication:

Singapore : Bentham Science Publishers, [2021]

Summary:

Surface enhanced Raman spectroscopy (SERS) is a technique applied in multidisciplinary research. Its use has tremendously grown in the last 40 years owing to improved nanofabrication, biomolecules extraction and sensitive signal acquisition techniques. This book focuses on the underlying principles of SERS by emphasizing on basic concepts and background information about the subject. Chapters explain the physics of Raman spectroscopy while also indicating its relevance to designing protocols and methodologies for biosensing and imaging. The book gives updated and recent details on colloids and nanostructures, their fabrication, surface engineering and immobilization methods, all in context to SERS based biosensing.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

State of the Art: Raman Vibrational Spectroscopy and Surface Enhanced Raman Spectroscopy

Jagjiwan Mittal1,* and Robin Kumar1

1.1. INTRODUCTION RAMAN VIBRATIONAL SPECTROSCOPY

1.1.1. History

1.1.2. Basic Theory

1.1.3. Raman Active Vibrations

1.1.4. Rule of Mutual Exclusion

1.1.5. Raman Spectrometer Instrumentation

1.1.6. Raman Spectrum

1.1.7. Applications of Raman Spectroscopy

1.1.7.1. Chemical Analysis

1.1.7.2. Solid State Physics

1.1.7.3. Nanotechnology

1.1.7.4. Bio-pharmaceutical Industry

1.1.7.5. Study of Historical Painting and Documents

1.1.7.6. Explosives

1.1.7.7. Sensing Based on Raman Spectroscopy

1.2. SURFACE-ENHANCED RAMAN SCATTERING (SERS)

1.2.1. Short History

1.2.2. SERS Mechanism

1.2.3. SERS Technique

1.2.4. SERS Substrates

1.2.5. Applications of SERS

1.2.5.1. Biomarkers

1.2.5.2. Toxic Chemical and Chemical Warfare Agents

1.2.5.3. Narcotic and Doping Drugs

1.2.5.4. Food Monitoring

1.2.5.5. Verification and Authentication of Luxury Goods and Currency

1.3. SURFACE ENHANCED RESONANCE RAMAN SPECTROSCOPY (SERRS)

1.3.1. Advantages of SERRS Over SERS

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Enhancement Mechanisms and Theory of SERS

Pragya Agar Palod1,* and Manika Khanuja2

2.1. INTRODUCTION

2.1.1. Introduction to SERS

2.2. ENHANCEMENT MECHANISMS

2.2.1. Electromagnetic Mechanism (EM)

2.2.1.1. Localized Surface Plasmon Resonance (LSPR)

2.2.2. Chemical Mechanism (CHEM)

2.2.3. Electronic Mechanism

2.3. ENHANCEMENT FACTORS

2.4. E4 ENHANCEMENT

2.5. FACTORS AFFECTING ENHANCEMENT FACTOR

2.5.1. SERS Substrate

2.5.2. Wavelength Dependence.

2.5.3. Distance Dependence

2.5.4. Dependence on the Size and Shape of the Nanoparticles

2.6. TWO-PHOTON EXCITED SERS

2.7. SINGLE MOLECULE DETECTION USING SERS

2.8. HOT SPOTS

2.8.1. Generations of Hot Spots

ACKNOWLEDGEMENTSS

Plasmonic and Non-plasmonic Resonance Materials in SERS

Harsimran Singh Bindra1 and Ranu Nayak2,*

3.1. INTRODUCTION

3.2. RAMAN REPORTER MOLECULES (RRM)

3.3. MATERIALS USED IN SERS

3.3.1. Plasmonic SERS Nanomaterials

3.3.2. Non-plasmonic SERS Materials

3.4. SOLID SERS SUBSTRATES

CONCLUDING REMARKS

Application of Raman Spectroscopy in Amyloid Research

Sandip Dolui1, Kaushik Bera1, Animesh Mondal1, Krishnendu Khamaru1 and Nakul C Maiti1,*

4.1. INTRODUCTION

4.1.1. Basics of Raman Spectroscopy

4.1.2. Raman Spectra of Proteins and Peptides

4.1.3. Raman Techniques in Bio-Analysis

4.2. AMYLOID PROTEIN AGGREGATES AND THEIR RAMAN SIGNATURE

4.2.1. Amyloid Protein Aggregates

4.2.2. Raman Signature of Amyloid Aggregates of Human Proteins

4.2.3. Raman Features of Protein Aggregates Produced by Lysozyme

4.2.4. An Estimation of Protein Secondary Structure by Amide I Band Analysis

4.2.5. Amyloid Fibril Formation Mechanism by Raman Analysis

CONCLUSION AND PERSPECTIVES

Surface-Enhanced Raman Scattering Based Rapid Pathogen Detection

Ujjal Kumar Sur1,* and Amar Ghosh1

5.1. INTRODUCTION

5.2. APPLICATIONS OF SERS

5.3. SERS BASED DETECTION OF VARIOUS BIOMOLECULES

5.3.1. Nucleotides and Nucleic Acids

5.3.2. Amino Acids and Peptides/Proteins

5.4. APPLICATIONS OF SERS IN PATHOGEN DETECTION.

5.5. RAMAN SPECTROSCOPY BASED DETECTION FOR COVID-19 TESTING

5.6. LIMITATION OF SERS TECHNIQUE IN PATHOGEN DETECTION AND FUTURE TREND

CONCLUSIONS

CONFLICT OF NTEREST

From Cells to Clinic - Direct Biomolecule Quantification of Clinically Relevant Biomolecules

Swati Jain1,2,*, Harsimran Singh Bindra3 and Sruti Chattopadhyay4,*

6.1. INTRODUCTION

6.2. DIAGNOSTIC SERS: KEY FEATURES AND ADVANTAGES

6.3. NEUROLOGICAL DISEASES

6.3.1. General Features

6.3.2. Detection of Neurotransmitters by SERS

6.3.3. New Technique: Surface Enhanced Spatially Offset Raman Spectroscopy (SESORS)

6.4. DIABETES-GLUCOSE MONITORING

6.4.1. The Rising Phenomenon Called Diabetes

6.4.2. Continuous Glucose Monitoring

6.4.3. Development of SERS Sensors for CGM

6.5. DISCREET CELLULAR MOLECULES AND CELLULAR MICROENVIRONMENT

6.6. MEDICAL IMAGING THROUGH SERS

Smartphone Based Biosensors on Lateral Flow Assay Coupled to SERS: Point-of-Care Applications

Rajasekhar Chokkareddy2, Suvardhan Kanchi1,3,*, Surendra Thakur4 and Venkatasubba Naidu Nuthalapati5,*

7.1. INTRODUCTION

7.1.1. What is POC Procedure

7.1.2. Recent POC Technologies

7.1.3. Biosensors

7.1.4. Smartphone-Based Biosensors

7.1.5. Challenges of Accepting POC in Emergency Department

7.1.6. Influence of POC on Clinical Results in the Emergency Department

7.1.7. Essential Features of POC Procedures

7.1.8. Surface Enhanced Raman Spectroscopy (SERS) and its Possible Advantages

7.1.9. Type of Substrates

7.1.10. What is it Used For

7.1.11. Usual SERS Investigational System

7.1.12. The Role of Surface Plasmons and Nanostructures

7.2. SERS BASED DNA AND PROTEIN DETERMINATIONS.

7.3. DETERMINATION OF OTHER BIOLOGICALLY RELATED NANOPARTICLES

Surface Enhanced Raman Spectroscopy- Bottlenecks and Improvement Strategies

Richa Jackeray1,*, Kriti Arya2, Zainul Abid CKV3 and Harpal Singh4,*

8.1. INTRODUCTION

8.1.1. Research

8.1.2. Commercialization

8.2. IMPROVEMENT STRATEGIES

8.2.1. Tip enhanced Raman Spectroscopy

8.2.2. Shell Isolated Nanoparticle-enhanced Raman Spectroscopy

8.2.3. Interference Enhanced Raman Spectroscopy (IERS)

8.2.4. Approach Based on Combinations and Spatio-temporal Resolution by Nanostructures

8.2.5. Improved Nanofabrication

8.2.5.1. Label Method

8.2.5.2. Label-free Method

8.2.6. Molecular Generality or Selectivity/Specificity Based Improvement Strategies

8.2.6.1. Reaction-SERS Method

8.2.6.2. Antibody-SERS Method

8.2.6.3. Aptamer-SERS Method

8.2.6.4. MIPs-SERS

8.2.6.5. Microfluidics-SERS

8.2.7. Collaborative Experimental and Theoretical Approaches

8.3. DEVELOPMENT IN INSTRUMENTATION

8.4. HANDHELD PORTABLE DEVICES

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print record.

Includes bibliographical references.

ISBN:

9789815039115

9815039113

OCLC:

1293243082