The role of reactive oxygen species in health and disease / Kuladip Jana, editor.

Format:

Book

Contributor:

Jana, Kuladip, editor.

Series:

Public health in the 21st century series.

Public health in the 21st century

Language:

English

Subjects (All):

Active oxygen--Pathophysiology.

Active oxygen.

Physical Description:

1 online resource (518 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"Reactive oxygen species (ROS) play an essential role in different biological functions, including physiological regulatory mechanisms to damaging alterations involved in the pathogenesis of an increasing number of human diseases. ROS are metabolic products from numerous cells, but two vital cellular organelles are intimately involved in their production and metabolism, i.e. the endoplasmic reticulum and the mitochondria. Excess cellular levels of ROS may cause damage to proteins, nucleic acids, lipids, membranes, and organelles, which may lead to the activation of cell death processes such as apoptosis. Apoptosis is a highly regulated process that is essential for the development and survival of multicellular organisms. These organisms often need to discard superfluous or potentially harmful cells, have accumulated mutations, or become infected by pathogens. Apoptosis features a characteristic set of morphological and biochemical features whereby cells undergo a cascade of self-destruction. Thus, proper regulation of apoptosis is essential for maintaining normal cellular homeostasis. Mitochondrial ROS (mtROS) play a central role in cell signaling and regulating the main pathways of apoptosis, mediated by mitochondria, death receptors, and the endoplasmic reticulum (ER) stress. This book focuses on the current understanding of the role of ROS in each of these three main pathways of apoptosis related to different human diseases, with particular emphasis on Metabolic, Inflammatory, Neurodegenerative, and Neoplastic diseases. It's promise and limitations are also discussed by targeting ROS with different antioxidants in preventing non-communicable diseases. The role of mtROS in the complex interplay and crosstalk between these different signaling pathways of apoptosis related to different human diseases remains to be unraveled further in future research"-- Provided by publisher.

Contents:

Reactive oxygen species act as double-edged swords in cancer progression and therapy / Satyajit Halder and Kuladip Jana

The interplay between endoplasmic reticulum stress mediated ROS generation and apoptosis in human diseases / Satyajit Halder, Nikhilesh Joardar, Raikumar Maiti, Shanti Prasad Sinha Babu Joardar, Debidas Ghosh and Kuladip Jana

The role of misfolded proteins on oxidative stress mediated neurodegeneration / Nikhilesh Joardar, Satyajit Halder, Santi Prasad Sinha Babu and Kuladip Jana

The mechanism of mitochondrial reactive oxygen species (mtROS) generation and its role in the apoptosis, pathogenesis of inflammatory and neurodegenerative disorders / Chirantan Majumder, Anirban Manna, Satyajit Halder and Kuladip Jana

Reactive oxygen species : its role in the aging of the brain and neurodegenerative diseases / Anirban Manna, Chirantan Majumder, Satyajit Halder and Kuladip Jana

Targeting reactive oxygen species (ROS) in the prevention of non-communicable diseases : the promise and limitations of antioxidant therapy / Satyajit Halder, Chirantan Majumder, Anirban Manna, Sarita Sarkar, Ankita Bhattachrya and Kuladip Jana

Parkinson's disease and oxidative stress / Nabanita Ghosh, Krishnendu Sinha and Parames C. Sil

The role of ROS in cancer progression and therapy / Subhajit Ghosh, Shrestha Dutta and Arghya Adhikary

Oxidative stress : a source of cellular plasticity and tumor heterogeneity / Leena Arora, Moyna Kalia, Kumari Bhavya and Durba Pal

The role of bioactive compounds and associated nanoparticles in the regulation of ROS : an innovative strategy in cancer therapy / Satish Kumar Vemuri, Chepuri Kalyani, C. D. S. L. N. Tulasi, D. Manikantha, G. P. V. Subbaiah and A. V. Gurava Reddy

Reactive oxygen species and cancer : a split self affair / Sangramjit Mondal, Aiindrila Dhara, Debkumar Pal and Nirmalya Sen

Interconnecting ROS and EMT : a way forward in cancer therapy / Debarpan Mitra, Depanwita Saha, Subhabrata Guha, Gaurav Das and Nabendu Murmu

The dynamic role of reactive oxygen species in relation to ovarian cancer / Aparaijita Pal, Sunita Jhulki and Sukanya Kundu

Therapeutic strategies targeting oxidative stress in diabetes / Abhishek Sehrawat, Jayapriya Mishra, Satinder Kaur, Inderpal Singh Sidhu, Bhawana Thukral, Gurjit Kaur Bhatti, Sarabjit Singh Mastana, P. Hemachandra Reddy and Jasvinder Singh Bhatti

Reactive oxygen species in the development and progression of Type 2 diabetes / Dipanjan Banerjee and Suman Dasgupta

Physiological and immunoregulatory roles of reactive oxygen species mediated signalling pathways in lymphatic filariasis / Pritha Chakraborty, Nabarun Chandra Das and Suprabhat Mukherjee

The impact of oxidative stress on male infertility induction and its management by nutraceuticals / Debidas Ghosh, AdrijaTripathy, Dipanwita Mitra and Puja Das

Fluoride and arsenic mediated oxidative damage causing disorders in the reproductive system / Priyankar Pal, Sagnik Biswas, Rubia Mondal and Prabir Kumar Mukhopadhyay

Rethinking endometriosis pathophysiology : judging the oxidative balance / Dr. Pratip Chakraborty, Imon Mitra and Dr. Ratna Chattopadhyay

The role of ROS-responsive biomaterials in bone-related diseases / Yu Wu, Wenhui Hu and Shiwu Dong

Stem cell : Ageing and senescence mechanisms / Ankita Das, Chandrayee Ghatak and Ananya Barui

Superoxide (O2-) : abiological prodigy for developing and curing disease / Asis Bala, Motlalepula Gilbert Matsabisa, Pallab Kanti Haldar, Subir Biswas and Ashis Kumar Mukherjee.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Jana, Kuladip The Role of Reactive Oxygen Species in Health and Disease

ISBN:

979-88-911-3330-3