Medicinal chemistry of drugs affecting cardiovascular and endocrine systems / M. O. Faruk Khan.

Format:

Book

Author/Creator:

Khan, M. O. Faruk, author.

Series:

Medicinal Chemistry for Pharmacy Students Series

Language:

English

Subjects (All):

Cardiovascular agents.

Pharmaceutical chemistry.

Physical Description:

1 online resource (405 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2024]

Summary:

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems is the third volume of the series. This volume features 8 chapters focusing on a comprehensive account of drugs affecting both the cardiovascular system and the endocrine functions. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detailed structure-activity relationships and metabolism. Topics covered include drugs that affect the renin-angiotensin system, calcium channel blockers, diuretics, hematological agents (anticoagulants, thrombolytic and antiplatelet agents), antidiabetics, antihistamines, proton pump inhibitors and therapeutic hormones. Each chapter also offers case studies and self-assessments to facilitate discussion and learning. The book equips students with a scientific foundation to competently evaluate, recommend and counsel patients and health care professionals regarding the safe, appropriate, and cost-effective use of medications. Students and teachers will also be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body. The information offered by the book chapters will give readers a strong neuropharmacology knowledge base required for a practicing pharmacist. Readership PharmD / pharmacology students and teachers.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Drugs Affecting Renin-Angiotensin System

M. O. Faruk Khan1,* and Karrie Murphy1

HISTORICAL BACKGROUND

INTRODUCTORY CONCEPTS

The Renin-Angiotensin System (RAS)

Angiotensin-Converting Enzyme Inhibitors (ACEIs)

Structure of ACE Active Site and Mechanism of Ang I Hydrolysis

Inhibition of ACE – The ACEI-ACE Interaction

Pharmacophore and SAR Summary of ACEIs

SAR Summary

The Individual ACEIs and their Structural and Therapeutic Evaluations

Sulfhydryl-Containing Inhibitor – Captopril

Dicarboxylate Containing Inhibitors

Phosphinate Containing Inhibitor - Fosinopril

ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS)

The AT1R Binding Pockets

Pharmacophore of ARBs and Structure-Activity Relationship

The Individual ARBs and their Structural and Therapeutic Evaluations

Recalls of the ARBs

Therapeutic Considerations of ACEI and ARBs

RENIN INHIBITOR ALISKIREN (TEKTURNA®) Generated by AI.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

ISBN:

9789815179729

OCLC:

1463068822