Current cancer biomarkers / Farhadul Islam, editor.

Format:

Book

Author/Creator:

Islam, Editor: Farhad Ul, Author.

Contributor:

Farhadul Islam, editor.

Language:

English

Subjects (All):

Cancer--Diagnosis.

Cancer.

Tumor markers--Diagnostic use.

Tumor markers.

Physical Description:

1 online resource (401 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2023]

Summary:

Current Cancer Biomarkers is a comprehensive review on the status of biological markers for various types of cancer. It aims to update readers on current developments on the subject. The contents are divided into 5 sections covering a wide range of biomarkers and their diagnostic applications. The range of tumour biomarkers referenced here gives insights into molecular mechanisms behind cancer, including initiation, development, progression, prognosis, response to the therapeutic modalities, recurrence, and point-of-care application to detect cancer. Key features - Introduction of the basic features of cancer markers - Comprehensive and updated coverage of potential and effective biomarkers including genomic, epigenomic, transcriptomic, proteomic, cellular and morphologic factors - Information on biomarkers in many types of cancers including breast cancer, colorectal cancer, skin cancer, leukemia, liver cancer and prostate cancer - Applications of biomarkers in cancer diagnosis - Structured contents with easy-to-understand sections and headings - References for advanced readers The updated information about different aspects of cancer markers in the experimental and clinical setting will enrich the reader's understanding of the disease. The information serves as a resource to help in better management of cancer patients and understanding cancer biology when planning medical research projects. The book is intended as a reference for a diverse audience: biomedical science students, medical students, academics, researchers, clinicians and multidisciplinary teams involved in cancer management and research.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Part 1: Introduction and Clinically Used Biomarker

Introduction: Current Status and Future Advances in Cancer Biomarkers

Farhadul Islam1,*

INTRODUCTION

Classical Cancer Biomarker

Diagnostic Cancer Biomarkers

Prognostic Cancer Biomarkers

Predictive Cancer Biomarkers

Future Cancer Biomarkers

CONCLUDING REMARKS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNKOWLEDGEMENT

REFERENCES

Tumour Markers in Clinical Use

Sujani M. K. Gamage1,2,*, Chamath D. Ranaweera3,4, Tracie T. Cheng1, Sharmin Aktar1,5, Vinod Gopalan1 and Farhadul Islam6

Markers for Colorectal Cancer

Diagnosis

Prediction of Prognosis

Follow up

Markers for Breast Cancer

Markers for Thyroid Cancer

Importance of Thyroglobulin in Differentiated Thyroid Cancer (DTC)

Surveillance after Thyroidectomy

Determination of the Requirement of Radioactive Iodine Therapy

Importance of Calcitonin in Medullary Thyroid Carcinoma (MTC)

Marker for Hepatocellular Carcinoma

Screening

Staging and Further Assessment

Surveillance in HCC

Markers for Gall Bladder and Cholangiocarcinoma

Markers for Pancreatic Carcinoma

Diagnosis and Workup

Markers for Ovarian Carcinoma

Markers for Testicular Carcinoma

Beta-hCG (β-hCG)

Lactate Dehydrogenase (LDH)

Alpha-Fetoprotein (AFP)

Markers in Neuroendocrine Tumours

Markers in Prostate Cancer

Treatment

CONCLUSION

ACKNOWLEDGEMENTS

Part 2: DNA/RNA Biomarkers

DNA Methylation Landscapes in Cancer and Non-Cancer Cells.

Shaun Stangl1,* and Vinod Gopalan1,*

Normal DNA Methylation Location

Aberrant DNA Methylation in Cancer Genomes

Methylation-Based Biomarkers

Bladder Cancer

Breast Cancer

Colorectal Cancer

Lung Cancer

Ovarian Cancer

Prostate Cancer

CONSENT OF PUBLICATION:

ACKNOWLEDGMENTS

Karyotyping and Chromosomal Aberrations in Cancer: Molecular and Diagnostic Biomarkers

Tracie T. Cheng1,*, Sujani M. K. Gamage1,2, Sharmin Aktar1, Vinod Gopalan1 and Farhadul Islam3,4

CHROMOSOMAL ABERRATIONS AND CANCER

The Cell Cycle Condensed

Structural Aberrations and Associated Cancer Markers

Genetic Biomarkers for Structural Chromosome Aberrations

DNA Damage Checkpoint

Replication Fork

DNA Repair

Characteristic Aneuploidy as a Cancer Marker and Its Associated Genes

The Centrosome and the Centromere

The Kinetochore-Microtubule Complex

The Spindle Assembly Checkpoint

ACKNOWLEDGEMENT

Tumour DNA Sequencing

Genetic Alterations in Cancer

Genetic Tests for Cancer

Thyroid Cancer

Pancreatic Cancer

Skin Cancer

Cancer Genome Sequencing: The Future of Precision Medicine

Circulating Tumour DNA: A Promising Cancer Biomarker

Sharmin Aktar1,2, Plabon Kumar Das3, Vinod Gopalan1, Alfred King-yin Lam1, 4 and Farhadul Islam5,*

CIRCULATING TUMOR DNA (CTDNA)

Biology of ctDNA

The Mechanism of ctDNA Entry into the Bloodstream

Detection of ctDNA.

ctDNA as a Promising Biomarker in Cancer Diagnosis and Prognosis

ctDNA as Diagnostic Biomarker

ctDNA as Prognostic Biomarker

Challenges

Circulating Tumour Cells in Solid Cancer

Sharmin Aktar1,2, Tracie T. Cheng1, Sujani M. K. Gamage1,3, Vinod Gopalan1 and Farhadul Islam3,4,*

Circulating Tumour Cells (CTCs): Cytomorphology, Biology and Isolation Techniques

CTCs in Solid Cancers

Gastrointestinal Tract Cancers

Head and Neck Cancer

Renal Carcinoma

Other Cancers

CTCs as Surrogate Biomarker in Clinical Application

CTCs as Diagnostic Biomarkers

CTCs as Prognostic Biomarkers for Survival Analysis

CTCS AS A PREDICTIVE BIOMARKER

In Treatment Monitoring

In Risk of Disease Relapse

Current Challenges in CTC Clinical Research

Part 3: Protein/Enzyme Biomarkers

Protein Cancer Biomarkers

Sarath S. Joseph1, Dan H. V. Tran1, Farhadul Islam2 and Vinod Gopalan1,*

PROTEIN BIOMARKERS

α-Smooth Muscle Actin (α-SMA)

BRAF

Breast Cancer Gene 1 and 2 (BRCA 1 and 2)

Calretinin

CD117

CD20

CD30

Chromogranin A

Cytokeratin (TPA, TPS &amp

CYFRA 21.1)

Desmin

Epidermal Growth Factor Receptor (EGFR)

Echinoderm Microtubule-Associated Protein-Like 4 (EML4) and Anaplastic Lymphoma Kinase (ALK) Fusion (EML4-ALK Fusion)

Estrogen Receptor/Progesterone Receptor (ER/PR)

FIP1-like-1/Platelet-derived Growth Factor Alpha (FIP1L1-PDGFRα)

Friend Leukaemia Integration-1 Protein (FLI-1)

Glial Fibrillary Acidic Protein (GFAP)

Gross Cystic Disease Fluid Protein-15 (GCDFP-15).

Human Epidermal Growth Factor Receptor 2 (HER2)/neu

hPG80

Human Melanoma Black 45 (HMB-45)

Inhibin

Keratin 17 and 19

KRAS

Melanoma Antigen Recognized by T cells 1 (MART-1)

Myogenic Differentiation 1 (MyoD1)

Muscle-Specific Actin (MSA)

Neurofilament

Platelet-Derived Growth Factor Receptor (PDGFR)

Promyelocytic Leukemia Protein-Retinoic Acid Receptor alpha (PML/RARα)

S100

Synaptophysin

Thyroid Transcription Factor 1 (TTF-1)

Vimentin

Enzymes: Tumour Associated Biomarker

Enzyme Biomarkers in Cancer

Ghrelin O-Acyl Transferase (GOAT)

Neuron Specific Enolase (NSE)

Alkaline Phosphatases (ALPs)

Thymidine Kinase 1 (TK1)

Tumour M2-PK

Urokinase-Type Plasminogen Activator (uPA)

Carbonic Anhydrase XII (CAXII)

Aldehyde Dehydrogenase 1 (ALDH1)

Matrix Metalloproteinases (MMPs)

Hexokinase (HK)

Glocuse-6-Phosphate Dehydrogenase (G6PD)

Glycoproteins and Cancer Biomarkers

Md Abedul Haque1,*

Protein Glycosylation in Cancer

Glycoproteins as Cancer Biomarkers

Glycoproteins in Liver Cancer

α-fetoprotein (AFP)

Sialyl Lewis A antigen (CA19-9)

Glycoproteins in Prostate Cancer

Prostate-Specific Antigen (PSA)

Glycoproteins in Ovarian Cancer

CA125 (Cancer Antigen 125)

Human Epidermis Protein 4 (WFDC2)

Glycoproteins in Breast Cancer

Mucin 1 (MUC1)

Human Epidermal Growth Factor Receptor 2 (HER2)

Carcinoembryonic Antigen (CEA)

Glycoproteins in Colon Cancer

CEA

Carbohydrate Antigen 19-9 (CA19-9)

Glycoproteins in Lung Cancer

Mucins.

Epidermal Growth Factor Receptor (EGFR)

Glycoproteins in Pancreatic Cancer

Cancer Antigen 19-9 (CA 19-9)

Part 4: Hormone &amp

Small Molecular Biomarkers

Hormones as Cancer Biomarkers

Plabon Kumar Das1, 2 and Farhadul Islam1, 2,*

HORMONES AS BIOMARKERS IN VARIOUS CANCERS

Peptide Hormones as Cancer Biomarkers

Calcitonin

Human Chorionic Gonadotropin (hCG)

Insulin

Gastrin

Glucagon

Prolactin

Thyroid Stimulating Hormone (TSH)

Steroid Hormones as Biomarker for Various Cancers

Estrogen

Progesterone

Testosterone

CONCLUSION AND PERSPECTIVE

miRNAs as Epigenetic Cancer Biomarker

Afraa Mamoori1,*

MiRNAs and Epigenetics

Mode of Action of MicroRNAs

Targets Selection by MicroRNAs

MiRNAs and Clinical Facts

Over 60% of Human Protein-coding Genes are Controlled by miRNA

Tissue-specific miRNAs

miRNAs Expressed in Different types of Body Fluid, and They are Highly Stable in Human Samples

miRNAs are Relevant Biomarkers in Cancer Diagnosis and Prognosis

Commercialized miRNAs, which are Currently in Clinical Practice as Diagnostic Markers

miRview Meso Test

miRview Squamous

miRview Lung

miRview Mets

miRview Kidney

Mirnas as Crucial Regulatory Marker in Epithelial-Mesenchymal Transition Process

Part 5: Novel Methods for Cancer Biomarker Detection

Electrochemical and Optical Detection of MicroRNAs as Biomarkers for Cancer Diagnosis

Riham Zayani1, Amira Ben Hassine1, Amal Rabti1, Amal Raouafi1 and Noureddine Raouafi1,*

INTRODUCTION.

What are miRNAs?.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Other Format:

Print version: Islam, Farhadul Current Cancer Biomarkers

ISBN:

9789815079364

OCLC:

1370493171