Human Papillomavirus Vaccination and Screening in the Elimination of HPV- Associated Cancers Evidence Base from Randomized Trials.

Format:

Book

Author/Creator:

Lehtinen, Matti.

Language:

English

Physical Description:

1 online resource (104 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2024.

Summary:

Human Papillomavirus Vaccination and Screening in the Elimination of HPV-Associated Cancers: Evidence Base from Randomized Trials explores cutting-edge strategies for eliminating HPV-associated cancers through vaccination and screening, showcasing findings from rigorous, evidence-based randomized trials. Key topics include the causative role of HPV in cancers, the effectiveness and safety of HPV vaccines, and the profound impact of gender-neutral vaccination programs. The book also covers innovative screening methods for vaccinated populations, addressing cervical and oropharyngeal cancers. Aimed at healthcare professionals, researchers, and students, this book provides crucial insights into the global efforts to combat HPV and its associated cancers. Key Features:- In-depth analysis of HPV's role in cancer causation.- Comprehensive coverage of HPV vaccine efficacy and safety.- Evaluation of gender-neutral vaccination impact on public health.- Advanced screening methods for cervical and oropharyngeal cancers in vaccinated individuals.- Data-driven recommendations for the future of HPV cancer prevention. Readership: Suitable for undergraduate and graduate students, healthcare professionals, and researchers.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

Etiological Studies on Cervical Neoplasia - A Showcase of Causal Inferencing

INTRODUCTION AND PREMISES

CHANGING SEXUAL RISK-TAKING BEHAVIOUR

ECOLOGICAL EVIDENCE ON CAUSES OF CERVICAL CANCER

EPIDEMIOLOGICAL EVIDENCE ON CAUSES OF CERVICAL CANCER

EVIDENCE ON INTERACTING AND INDEPENDENT CARCINOGENS

GENETIC EFFECT MODIFIERS IN CERVICAL CARCINOGENESIS

CONCLUSION

METHODS

Finnish Maternity Cohort sub-samples

Microbial Serology

HLA Prevalence Data

Data on Incident Cervical Cancer Cases and Cancer Incidence Data

Mapping Method

Data on Risk Taking Behaviour

Safety, Immunogenicity and Efficacy of Human Papillomavirus Vaccines

SAFETY OF HUMAN PAPILLOMAVIRUS VACCINES

IMMUNOGENICITY OF HUMAN PAPILLOMAVIRUS VACCINES

EFFICACY OF HUMAN PAPILLOMAVIRUS VACCINES

Safety Studies

Immunogenicity Studies

Long-term Vaccine Efficacy Studies

Impact of Different Human Papillomavirus Vaccination Strategies

HERD EFFECTS GENERATED BY GENDER-NEUTRAL AND GIRLS-ONLY HPV VACCINATION

OVERALL EFFECTIVENESS OF GENDER-NEUTRAL VERSUS GIRLS-ONLY HPV VACCINATION

A Priori Defined Statistical Analysis Plan and Power

Determination of Vaccine Effectiveness, Herd Effect and Protective Effectiveness

Role of the Independent Laboratory and International Steering Committee of the Trial

Vaccination and Human Papillomavirus Type-replacement

EPIDEMIOLOGICAL APPROACHES TO HPV-VACCINATION AND ASSOCIATED TYPE-REPLACEMENT

THE MODELLING APPROACH TO UNDERSTANDING HPV-VACCINATION ASSOCIATED TYPE-REPLACEMENT

ECOLOGICAL APPROACHES TO HPV-VACCINATION AND ASSOCIATED TYPE-REPLACEMENT.

CONCLUSION

Epidemiological Analyses

Mathematical Modelling

Ecological Analyses

Screening and Triage of Cervical Neoplasia in HPV-vaccinated Women

SAFETY OF INFREQUENT CERVICAL SCREENING OF HPV-VACCINATED WOMEN

INFREQUENT CERVICAL SCREENING OF HPV-VACCINATED WOMEN

PROGRESSION POTENTIAL OF HSIL IN HPV-VACCINATED WOMEN - EARLY AND LATE STAGE TRIAGE

HPV PERSISTENCE AND PROGRESSION OF HSIL IN HPV-VACCINATED WOMEN - EARLY STAGE TRIAGE

HPV PERSISTENCE AND PROGRESSION OF HSIL IN HPV-VACCINATED WOMEN - LATE STAGE TRIAGE

INFREQUENT SCREENING OF HERD EFFECT PROTECTED UNVACCINATED WOMEN

Cohort

Antibody Analyses

HPV Typing

Methylation Marker Analyses

Statistics

Screening of Human Papillomavirus Related Oropharyngeal Cancers

PREREQUISITES OF PREVENTATIVE MEASURES AGAINST HPV-ASSOCIATED OPSCC

PROPHYLACTIC HPV VACCINATION AGAINST OROPHARYNGEAL INFECTIONS

SCREENING OF HPV-ASSOCIATED OPSCC

Serological Screening

DNA Screening

STEP-WISE COMBINATION OF THE PREVENTIVE MEASURES

COST-EFFICIENCY OF OPSCC-PREVENTION

Material

Serology

HPV DNA Analyses

Endgame

Acknowledgements

References

Specific Webpage for the Lectures

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Lehtinen, Matti Human Papillomavirus Vaccination and Screening in the Elimination of HPV- Associated Cancers Evidence Base from Randomized Trials

ISBN:

9789815305487