The Chemistry of Pyrimidine Derivatives / edited by Barry Schneider.

Format:

Book

Contributor:

Schneider, Barry (Editor), editor.

Series:

Chemistry research and applications series.

Chemistry Research and Applications Series

Language:

English

Subjects (All):

Pyrimidines--Derivatives.

Pyrimidines.

Pyrimidines--Derivatives--Analysis.

Pyrimidines--Derivatives--Therapeutic use.

Physical Description:

1 online resource (180 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"This book is a compilation of six chapters on the chemistry of pyrimidine derivatives. Chapter one sums up the pharmacological potential of pyrimidine derivatives and provides an overview of recent literature studies of these unique compounds as anti-inflammatory agents. Chapter two covers various pyrimidine derivatives with powerful biological and pharmacological applications. The authors in chapter three answer the question of how did the pyrimidine bases form on the Earth, i.e., how did they evolve? Chapter four begins with an introduction to pyrimidine's structure and then delves into the diverse reactions of pyrimidine derivatives. Chapter five presents the applications of pyrimidine derivatives in the adsorption of heavy metals, which are environmental pollutants. The final chapter provides readers with an assessment of the molecular targets linked to cancer, aiming to clarify their role in disease advancement and the possibility for treatment"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

Pyrimidine Derivatives as Anti-Inflammatory Agents

Abstract

1. Introduction

2. Pharmacological Potential of Pyrimidine Derivatives

3. Recent Advances in the Anti-Inflammatory Properties of Pyrimidines

Conclusion

References

Chapter 2

Studies on Pyrimidine Derivatives

2. Clinical Significance of Pyrimidine Analogues

2.1. Anti-Cancerous Pyrimidine Derivatives

2.2. Sedative and Hypnotic Pyrimidine Analogues

2.3. Antibiotic Pyrimidine Derivatives

2.4. Antiviral Pyrimidine Derivatives

2.4.1. Anti-Herpes

2.4.2. Anti-HIV

Chapter 3

The Evolution of Pyrimidine Bases

1.1. A Brief View At The Early World

1.2. Formation of Pyrimidines And Some Hypotheses Related To Pyrimidines

1.3. The Structure and the Discovery of Pyrimidines

1.4. Theoretical Calculations

Chapter 4

The Versatility of the Pyrimidine Ring: Synthesis, Reactions, and Advanced Applications

2. Source of Atoms in the Pyrimidine Ring

3. Aromaticity of Pyrimidine

4. Synthesis of Pyrimidine and Its Derivatives

4.1. Pinner-Type Synthesis

4.2. Synthesis of Pyrimidines from (2,2,2 Trichloroethylene) Acetophenones and Amidines

4.3. Sequential Suzuki Coupling/Condensation Reaction

4.4. Green One-Pot Synthesis of Pyrimidine from Nitriles

4.5. Green Synthesis of Phthalide Fused Pyrimidine

4.6. Oxidative Copper-Catalyzed Condensation of Ketones and Amidines

4.7. Kemp's Three-Component Synthesis of Pyrimidine

4.8. Kemp's Four-Component Synthesis of Pyrimidine

4.9. Kirchner Three Component Synthesis of Pyrimidines

4.10. Diels - Alder Cycloaddition between 1,2,3-Triazine and Amidines.

4.11. Microwave Method for Synthesis

4.11.1. Preparation Methods

5. Reactions of Pyrimidine

5.1. Alkylation Reaction

5.2. Oxidation

5.3. Reduction

5.4. Nitration

5.5. Halogenation Reaction

5.6. Diazo Coupling Reaction of Pyrimidine

5.7. Vilsmeier-Haack Reaction

6. Medicinal Uses

6.1. Antibacterial Activity

6.1.1. Antifolates are Medications that Work against Folic Acid

6.1.2. A Class of Medication Known as Sulfa Medicines Includes Pyrimidine

6.1.3. New Advances in Pyrimidine as an Antibacterial Drug (Pyrimidine-Conjugated Fluoroquinolones)

6.2. Antiviral Activity

6.3. Antifungal Activity

6.4. Anti-Alzheimer's Activity

6.5. Anti-Hepatic Activity

6.6. Anticancer Activity

6.7. Anti-Thyroid Activity

6.8. Antitubercular Activity

6.9. Anthelmintics Activity

6.10. Anti-Inflammatory Activity

7. Latest Pyrimidine Studies

7.1. Effective Approaches for Identifying Chromosomal Markers in Lactococcus Lactis: Analyzing Mutants of the Pyrimidine Salvage Pathway Obtained through Positive Selections

7.2. A Novel Pyrimidine-Based Red Fluorescent Probe Model for Detection of Hydrogen Peroxide in Parkinson's Disease

7.3. Inhibition of Copper Corrosion in Synthetic Seawater Using Pyrazole Pyrimidine Derivative

7.4. Novel Pyrimidine-Tagged Silver Nanoparticles-Based Fluorescent Immunoassay for the Detection of Pseudomonas aeruginosa

7.5. Bioinspired Pyrimidine-Containing Cationic Polymers as Efficient Nano-Carriers for DNA and Protein Delivery

7.6. Gold and Platinum Nanoparticles Capped with Novel Pyrimidine-Based Ligands

Chapter 5

The Use of Pyrimidine Derivatives as Adsorbents for the Removal and Extraction of Heavy Metal Ions

2. Adsorption of Heavy Metals by Pyrimidine Derivatives

Acknowledgments.

References

Chapter 6

Pyrimidine Derivatives: A Crucial Scaffold in Discovery of Anti-Cancer Agents

Introduction

Pyrimidine: 1,3-diazine

Structure Activity Relationship of substituted Pyrimidine Derivatives

Di-Substituted Pyrimidines

Tri-substituted Pyrimidines

Tetra-Substituted Derivatives

Pyrazolopyrimidines

Pyridopyrimidines

Pyrrolopyrimidines

Index

Blank Page.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references and index.

ISBN:

9798891136120