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The dangers of allergic asthma / edited by Jesús Miguel García-Menaya.
EBSCOhost Academic eBook Collection (North America) Available online
EBSCOhost Academic eBook Collection (North America)- Format:
- Book
- Series:
- Immunology and Immune System Disorders Series
- Language:
- English
- Subjects (All):
- Allergy--Periodicals.
- Asthma--Etiology.
- Physical Description:
- 1 online resource (332 pages)
- Edition:
- 1st ed.
- Place of Publication:
- New York, New York : Nova Science Publishers, Incorporated, [2023]
- Summary:
- "This book describes in depth the potential dangers of allergic asthma, like thunderstorm-asthma outbreaks, occupational asthma, allergic bronchopulmonary aspergillosis and new potential threats like climate change and air pollution influencing asthma. There are also other chapters describing the epidemiology, immunology and allergens related to allergic asthma. The concept of united airway disease is reviewed, and special situations like severe asthma and aspirin-exacerbated respiratory disease are also covered. Chapters about diagnostic approach and primary treatments, including biologics and clinical pharmacogenomics in asthma therapy, contributes to a more complete knowledge about this complex, fascinating and sometimes dangerous disease"-- Provided by publisher.
- Contents:
- Intro
- Contents
- Preface
- Chapter 1
- Epidemiology of Asthma
- Abstract
- Introduction
- Definition
- Risks Factors
- Epidemiological Studies
- Prevalence and Incidence
- Prevalence in Children
- Prevalence in Adults
- Hospitalizations
- Mortality
- Asthma and COVID-19
- Conclusion
- References
- Chapter 2
- Immunology of Allergic Asthma and T2 Inflammation in Allergic Asthma
- T2 Asthma (Or High T2)
- Lung Microbiota
- The Lung-Gut Axis
- Epithelial Cells
- Allergens
- Dendritic Cells (DCs)
- Th2/Th9/Tfh Lymphocytes
- Regulatory T Cells (Tregs)
- Unconventional T Cells: NKT Cells (Natural Killer T Cells), MAIT Cells (Mucosal Associated Invariant T Cells) and T Lymphocytes
- Immunoglobulin E
- Innate Lymphoid Cells Type 2 (ILC2)
- Eosinophils
- Mast Cells
- Basophils
- Chapter 3
- Pollens Causing Asthma
- Pollen Sensitization
- Main Pollens Causing Asthma and Their Allergens
- Poaceae Pollen
- Tree Pollen
- Betulaceae
- Oleaceae
- Cupressaceae
- Platanaceae
- Weed Pollen
- Ragweed
- Parietaria
- Chapter 4
- Mites and Fungal Spores Causing Asthma
- Dust Mites
- Discovery of the Role of Dust Mites in Allergic Diseases
- Classification of Dust Mites
- Dust Mite Allergens
- Prevalence of Dust Mite Allergies
- Factors Involved in the Development of Asthma in Patients with HDM Allergy
- Occupational Asthma Caused by Dust Mites
- Diagnosis
- Treatment
- Summary of House Dust Mites
- Fungi
- Atmospheric Concentrations of Fungal Spores
- Involvement of Fungi in Allergic Diseases
- Prevalence
- Association between Asthma and Fungal Allergy
- Occupational Fungal Asthma
- Treatment.
- Summary of Fungal Spores
- Chapter 5
- Diagnosis of Asthma: Clinical Symptoms and Tests
- Clinical Approach
- Key Questions for the Identification of Patients with Suspected Asthma [1, 2]
- Ask About [1, 2]
- Physical Examination [1]
- Respiratory Function Tests
- Spirometry [3]
- Bronchodilator Response (BDR)
- Severity of Lung Function Impairment
- FeNO
- Does FeNO Help in Deciding Whether to Commence Inhaled Corticosteroids (ICS)?
- Oscillometry
- Bronchoprovocation Tests
- Pharmacologic Challenge
- Methacholine
- Mannitol
- Interpretation [3, 4, 12]
- Difficult Interpretations
- Exercise Challenge
- Quality of Life Assessment [1, 2]
- Assessment of QoL of Asthma in Children
- Diagnosis of Asthma in Special Conditions [1]
- Occupational Asthma and Work-Exacerbated Asthma
- Pregnant Women
- Patients with Persistent Cough as the Only Symptom [1, 2]
- Exercised-Induced Asthma
- Aspirin-Exacerbated Respiratory Disease (AERD)
- Asthma and COVID-19 [1, 2]
- Chapter 6
- Occupational Allergic Asthma
- Epidemiology
- Causal Agents
- Clinical Manifestations and Phenotypes
- Allergic Occupational Asthma Caused by High-Molecular Weight Agents
- Allergic Occupational Asthma Caused by Low-Molecular Weight Agents
- Exposure Assessment
- Management
- Prevention
- Chapter 7
- Severe Asthma
- Epidemiology and Burden
- Risk Factors
- Mechanisms
- T2 Severe Asthma
- Non-T2 Severe Asthma
- Shared Pathogenetic Pathways
- Evaluation
- Pulmonary Function Testing
- Imaging
- Inflammometry
- Comorbidities
- Chapter 8
- An Update on Thunderstorm Allergy and Asthma
- Abstract.
- Introduction
- Chapter 9
- Asthma and Climatic Change
- Climatic Change and Pollen Allergy
- Increase in Patients with Pollinosis
- Increase in Pollen Counts and Early Onset of the Pollen Season
- Role of CO2 in Pollen Production
- Role of CO2 on Pollen Allergenicity
- Role of Climate Change in the Spread of Ragweed in Europe
- Climatic Change, Pollen Counts and Pollinosis in Madrid
- Winters with More Pollinosis Symptoms
- Climatic Change and Grass Pollen
- Climate Change and Thunderstorm Asthma Due to Grass Pollen
- Climatic Change and Fungi Asthma
- Climatic Change and Dust Mites Asthma
- Chapter 10
- Air Pollution and Asthma
- Environmental Pollutants
- Nitrogen Oxides
- Ozone
- Particles
- Seasonal Asthma and Industrial Pollution
- Seasonal Asthma and Urban Pollution
- Asthma and Tobacco Smoke
- Asthma, Environmental Pollution, and the Immune Response
- Effect of Pollution on the Development of Allergic Diseases
- Exacerbation of Asthma by Pollution
- Effect of Pollution on Allergens that Trigger Asthma
- Chapter 11
- Allergic Asthma and Viruses
- Asthma, Allergens and Viral Infections: An Intricate Relationship
- Are Viruses a Hazard or Protection for Allergic Sensitization? Does Allergy Diminish the Antiviral Response Promoting Exacerbation of Asthma?
- Clinical Course and Management Principles of Viral-Induced Acute Asthma Exacerbations
- Asthma and COVID-19: What Have We Learned?
- Future Therapeutic Advances in the Treatment of Asthma Exacerbated by Viruses
- Chapter 12
- United Airway Disease
- Anatomy
- Pathophysiology Triggers
- Pathophysiology Inflammation.
- Endophenotypes
- Allergic Asthma-Rhinitis
- Local Allergic Rhinitis-Asthma (Local Respiratory Allergy)
- Chapter 13
- Allergic Bronchopulmonary Aspergillosis
- Pathophysiology
- Serology: Total IgE and Specific IgE to Aspergillus fumigatus
- Serology: Serum Precipitins and Specific IgG to Aspergillus fumigatus
- Sputum Cultures
- Lung Function
- Radiology
- Evolution and Staging
- Glucocorticoids
- Antifungal Therapies
- Monoclonal Antibodies
- Mucolytics
- Management of APBA
- Chapter 14
- Aspirin-Exacerbated Respiratory Disease
- Clinical Features
- Pathogenesis
- Biomarkers
- Quantification of Peripheral and Local Eosinophils
- Other T2 Biomarkers
- Atopy and Allergy Tests
- Specific Biomarkers for AERD
- Diagnostic Approach
- Clinical History
- ASA Challenge
- Avoidance of NSAIDs
- Pharmacological Treatment
- Corticosteroid Treatment
- Leukotriene-Modifying Drugs (LTMDs)
- Antibiotics
- Aspirin Therapy after Desensitization
- Biological Agents
- Surgery
- Chapter 15
- Pharmacological Treatment of Asthma
- Maintenance Treatments
- Inhaled Corticosteroids (ICS)
- ICS/LABAs
- Long-Acting Muscaring Anatagonists (LAMA)
- Triple Therapy ICS/LABA/LAMA
- Leukotriene Receptor Antagonists
- Systemic Corticosteroids
- Allergen Immunotherapy (AIT)
- Rescue Treatments
- Short-Acting Beta2 Agonists (SABAs)
- Short-Acting Muscarinic Antagonist (SAMA)
- ICS/SABA
- ICS/LABA
- Chapter 16
- Immunotherapy for Asthma
- Introduction: Allergen Immunotherapy as Treatment for Respiratory Allergy
- Principal Routes of Allergen Immunotherapy Administration.
- Indications of Allergen Immunotherapy in Allergic Asthma
- Contraindications of Allergen Immunotherapy
- Risk of Systemic Reactions during Allergen Immunotherapy
- Allergen Immunotherapy Biomarkers
- Biomarkers in Asthma
- Biomarkers in Specific Immunotherapy
- In Vitro Biomarkers
- IgE and IgG
- Cellular Changes
- Basophil Activation Tests
- Serum Cytokines
- In Vivo Biomarkers
- Skin Prick Test Reactivity
- Controlled Exposure Tests
- Allergen Immunotherapy as an Example of Precision Medicine in Bronchial Asthma
- Clinical Trials in Allergen Immunotherapy
- What Is the Best Outcome?
- Placebo Effect on Allergen Immunotherapy
- Modification of the Nature of the Placebo
- Elimination of the Placebo Arm
- Application of Digital Systems (mHealth) and Big Data
- Cost-Efficacy Studies of AIT in Asthma
- Chapter 17
- Biological Treatments for Asthma
- Biologics
- Anti-IgE
- Omalizumab
- Mechanism of Action
- Efficacy
- Indications and Safety
- Anti-IL5
- Mepolizumab
- Reslizumab
- Benralizumab
- Anti-IL-4/IL-13
- Dupilumab
- Anti-Epithelial Cytokine Antibodies
- Tezepelumab
- Itepekimab
- Astegolimab
- Indirect Treatment Comparisons among Biologics
- Selection of Biologic for Severe Uncontrolled Asthma
- Chapter 18
- Clinical Pharmacogenomics in Asthma Therapy
- Drugs Used in Asthma Treatment
- Inhaled Corticosteroids (ICSs)
- Anti-Leukotriene Agents
- Beta-Agonists
- Biological Agents.
- Future Directions.
- Notes:
- Description based on print version record.
- Includes index.
- Other Format:
- Print version: García-Menaya, Jesús Miguel The Dangers of Allergic Asthma
- ISBN:
- 9798886977240
- OCLC:
- 1376196705
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