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New research on bone metastasis / Joseph Gerfried (editor).
- Format:
- Book
- Series:
- Cancer Etiology, Diagnosis and Treatments Series
- Language:
- English
- Subjects (All):
- Bone metastasis.
- Physical Description:
- 1 online resource (132 pages)
- Edition:
- 1st ed.
- Place of Publication:
- New York : Nova Science Publishers, Inc., [2023]
- Summary:
- "This book focuses on the latest developments in bone metastasis research, including: The application of m6A in the early diagnosis and therapeutic implications of bone metastasis The role of extracellular vesicles in bone metastasis The role of estrogen in affecting the immunological microenvironment of bone metastasis The etiology, pathogenesis, presentations, investigations, classification and management of spinal metastasis The pivotal role macrophages play in bone metastasis The evolving cancer-bone coupling effects during bone metastasis"-- Provided by publisher.
- Contents:
- Intro
- Contents
- Preface
- Chapter 1
- The Crucial Role of m6A Modification in Bone Cancer Metastases
- Abstract
- Introduction
- m6A RNA Methylation-Related Enzymes
- The Dual Role of m6A during Bone Metastasis In Situ of OS
- The Biregulatory Role of m6A in Tumor-Associated Distant Bone Metastasis
- Conclusion and Future Perspectives
- References
- Chapter 2
- The "Communicator" Role of Extracellular Vesicles in Bone Metastasis
- Bone Remodeling and Bone Metastasis
- Bone Metastasis and EVs
- Prostate Cancer
- Breast Cancer
- Lung Cancer
- Perspectives on EV Applications
- EV Components as Diagnostic or Prognostic Biomarkers
- EVs as the Vehicle of Drug Delivery Systems (DDS) and Vaccinations
- Strategies of EV-Targeting Therapy
- Conclusion
- Chapter 3
- Metastatic Disease of the Spine
- Pathogenesis and Pathology
- Presentations of a Patient with Spinal Metastatic Disease
- Mechanical Instability in SMD
- Neurological Involvement
- Histology of Tumors
- Prognostic Staging of SMD
- NOMS
- LMNOP
- Imaging in Spine Metastasis
- Management of Spinal Metastasis
- Nonoperative Treatment
- Percutaneous Interventions
- Vertebroplasty and Kyphoplasty
- Radiotherapy
- Stereotactic BT
- Surgical Treatment
- Separation Surgery
- Minimally Invasive Spine Surgery for Spinal Metastasis
- Chapter 4
- The Crucial Role of Estrogen and Relevant Receptors in Cancer Associated Bone Metastasis
- Estrogen in Osteoclasts
- Estrogen in Monocytes-Macrophages
- Estrogen in Bone Homeostasis during Bone Metastasis
- Conclusion and Perspective
- Chapter 5
- Evolving Cancer-Bone Coupling Effects During Bone Metastasis
- Bone Homeostasis.
- Premetastatic Niche
- The Perivascular Niche
- The Endosteal Niche
- The Vicious Cycle
- Chapter 6
- Macrophages' Promotion of Bone Metastasis
- Macrophages' Actions on Bone Homeostasis
- The Role of Macrophages in Bone Resorption
- Macrophages' Contribution to Bone Formation
- The Function of Macrophages in Bone Metastatic Cascade
- Conclusion and Future Prospectives
- Index
- Blank Page
- Blank Page.
- Notes:
- Description based on print version record.
- Includes bibliographical references and index.
- Other Format:
- Print version: Gerfried, Joseph New Research on Bone Metastasis
- ISBN:
- 9798886978254
- OCLC:
- 1379467911
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