Genotoxicity, advances in research and applications / edited by Chibuisi Gideon Alimba [and seven others].

Format:

Book

Contributor:

Alimba, Chibuisi Gideon, editor.

Series:

Chemistry research and applications series.

Chemistry research and applications

Language:

English

Subjects (All):

Genetic toxicology.

Physical Description:

1 online resource (188 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"The Induction of genotoxic effects on prokaryote and eukaryotes' genetic materials is a crucial step in the initiation of cancer and genotoxic disease syndromes. Cancer risk assessment and other genetic disease syndromes required the application of genotoxicity biomarkers. Several genotoxicity assays have been developed and applied to assess the potentials for xenobiotics to induce DNA damage. In the edited book: "Genotoxicity: Advances in Research and Applications", the applications of genotoxicity biomarkers were used to monitor heat-induced genotoxic agents in the reproductive system. Genotoxicity assays were applied in the assessment of genomic instability induced by environmental xenobiotics (including cement dust and pesticides) that humans and biota are exposed to in occupational settings and the environment. Advances in the application of genotoxicity include the use of in silico techniques to predict the genotoxic potentials of xenobiotics including pharmaceuticals which are increasingly being accumulated in the environment. Renounced authors in the field of genotoxicity have made comprehensive contributions to achieve the quality of the book contents"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

The Genotoxic Effects of Heat-Induced Food Contaminants in the Male Reproductive System

Abstract

1. Introduction

2. Source of Food Contaminants

3. Contaminants Resulting from Food Heating Processes and Possible Human Health Effects

4. Genotoxic Mechanism of Heat-Induced Food Toxicants on the Male Reproductive System

4.1. Acrylamide

4.1.1. Exposure and Metabolism

4.1.2. Genotoxicity

4.2. Furan

4.2.1. Exposure and Metabolism

4.2.2. Genotoxicity

4.3. 5-hydroxymethylfurfural

4.3.1. Exposure and Metabolism

4.3.2. Genotoxicity

4.4. Acrolein

4.4.1. Exposure and Metabolism

4.4.2. Genotoxicity

4.5. Heterocyclic Aromatic Amines

4.5.1. Exposure and Metabolism

4.5.2. Genotoxicity

4.6. Nitrosamines

4.6.1. Exposure and Metabolism

4.6.2. Genotoxicity

4.7. Polycyclic Aromatic Hydrocarbons

4.7.1. Exposure and Metabolism

4.7.2. Genotoxicity

4.8. Chloropropanols and Chloroesters

4.8.1. Exposure and Metabolism

4.8.2. Genotoxicity

Conclusion

References

Biographical Sketch

Chapter 2

The Use of In Silico Models in the Prediction

of Genotoxicity Potentials of Pharmaceuticals

1.1. In Silico Models

1.2. Quantitative Structure-Activity Relationship (QSAR) Modeling

Biographical Sketches

Chapter 3

In Vitro and In Vivo Applications of Genotoxicity Biomarkers in the Assessment of Pesticides

Introduction

1.1. Pesticides: Definition, Uses, Classification, and Exposure

2.0. Genotoxicity Biomarkers in Pesticide Exposure

2.1.1. Micronuclei (MN) and Nuclear Abnormalities (NA)

2.1.2. Chromosomal Aberrations (CA)

2.1.3. Sister Chromatid Exchanges (SCEs)

2.1.4. Alkaline Comet assay

Chapter 4.

Occupational Exposure and Genome Instability: The Effects on Human Health

2. Human Biomonitoring

3. Biomarkers

3.1. Exposure Biomarkers of Genotoxicity

3.2. Effect Biomarkers of Genotoxicity

3.3. Susceptibility Biomarkers of Genotoxicity

4. Case Study of Occupational Exposure to Xenobiotics and Health Effects

5. Final Considerations

Chapter 5

The Genotoxicity of Cement Dust: Current Screening Advances and Future Prospects

1.1. Chemical Composition and Exposure Pathway to Cement Dust

2. Genotoxicity Assays in the Assessment of Genotoxic Potentials of Cement Dust

2.1. The Use of Comet Assay in the DNA Damaging Potentials of Cement Dust

2.2. Micronucleus Test

2.3. Use of 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) in the Oxidative DNA Damage Assessment of Cement Dust

2.4. Random Amplified Polymorphic DNA (RAPD)

2.6. Use of Allium cepa Assay to Assess Cement Dust Genotoxicity

2.7. Use of γ-H2AX to Assess Cement Dust Genotoxicity

3. Future Research Prospects

Index

Blank Page.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Alimba, Chibuisi Gideon Genotoxicity: Advances in Research and Applications

ISBN:

979-88-911-3226-9

OCLC:

1414468759