The Pulmonary Vasculature in Chronic Lung Disease / edited by Farbod N. Rahaghi, Laszlo Farkas, Oksana A. Shlobin.

Format:

Book

Author/Creator:

Rahaghi, Farbod N.

Contributor:

Rahaghi

Series:

Respiratory Medicine, 2197-7380

Language:

English

Subjects (All):

Respiratory organs--Diseases.

Respiratory organs.

Cardiology.

Pneumology.

Local Subjects:

Pneumology.

Cardiology.

Physical Description:

1 online resource (405 pages)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Humana, 2025.

Summary:

This book comprehensively covers pulmonary vascular disease and its relation to lung disease. Pulmonary vascular disease is a major complication of all types of lung disease including smoking related lung disease (COPD, emphysema) and interstitial lung disease, serving as significant source of morbidity and mortality in these patients. The co-evolution of lung disease and vascular disease is a very interesting area of research activity in an attempt both to understand and seek treatments for disease of the lung as well as to risk stratify and prevent the development of pulmonary hypertension in these patients. At the same time, there is significant clinical interest in diagnosing, phenotyping and treating patients with lung disease complicated by pulmonary hypertension, in part due to several new mechanistic agents that are coming to the market for treatment of pulmonary hypertension, as well as the first ever large positive clinical trial of the treatment of pulmonary hypertensionassociated with ILD. These chapters, written by experts in the field, bring together topics spanning the biology, pathophysiology and clinical diagnosis and treatment of pulmonary vascular disease in the context of chronic lung diseases. It also spans all major types of lung disease, dividing the topics based on pathophysiology as well as clinical phenotype. It contains within it both the latest research directions in the field for the research driven reader, but also the clinical recommendations and the pathways of likely clinical development in the field for both the treating clinicians as well as the clinical opinion leaders and directors of clinical research. This is an ideal guide for pulmonary physicians taking care of patients with lung disease or pulmonary hypertension, cardiologists taking care of pulmonary hypertension patients with lung disease, rheumatologists, and translational researchers in the field of lung biology and pulmonary vascular physiology.

Contents:

Introduction

Lung endothelial cells and their heterogeneity in chronic lung diseases

Mesenchymal vascular cells in chronic lung diseases – pericytes smooth muscle cells and adventitia fibroblasts

Platelets and thrombosis in lung disease

Biology of extracellular matrix in pulmonary vascular pathology associated with chronic lung diseases

Genetics and population-based risk factors for pulmonary vascular disease associated Chronic Lung Disease

Imaging of the pulmonary vasculature and right ventricle in lung disease

Omics and precision medicine approaches in pulmonary vascular diseases associated with chronic lung disease

Cardiopulmonary coupling in lung disease

The pathophysiology diagnosis and clinical impact of pulmonary hypertension in in emphysema COPD and smoking related lung disease

Diagnosis clinical impact and treatment of pulmonary hypertension associated with interstitial lung disease)

Pulmonary hypertension associated with sarcoidosis

The challenge of designing clinical trials in lung disease complicated by pulmonary vascular disease

Pulmonary vascular disease associated with ARDS and post-COVID syndromes

Pulmonary vascular disease associated with other parenchymal lung diseases post TB chronic lung disease CF LAM neurofibromatosis, Histiocytosis X

Pulmonary vascular disease associated with hypoxemia and elevation

Future Directions.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

3-032-03581-3

9783032035813

OCLC:

1572182760