Imaging Blood-Brain Barrier Dysfunction in Brain Disorders.

Format:

Book

Author/Creator:

Wang, Danny J. J.

Language:

English

Subjects (All):

Blood-brain barrier.

Magnetic resonance imaging.

Physical Description:

1 online resource (202 pages)

Edition:

1st ed.

Place of Publication:

Chantilly : Elsevier Science & Technology, 2025.

Summary:

Imaging Blood-Brain Barrier Dysfunction in Brain Disorders delves into the intricate structure and function of the blood-brain barrier (BBB), examining its essential role in the pathogenesis of various brain disorders.

Contents:

Front Cover

Imaging Blood-Brain Barrier Dysfunction in Brain Disorders

About the Cover

Copyright

Dedication

Contents

Preface

Acknowledgments

One - Biology of the blood-brain barrier (BBB)

1.1 History of BBB discovery

1.2 Structure and function of BBB

1.2.1 Endothelial cells and tight junctions

1.2.2 Pericytes and basement membrane

1.2.3 Astrocytes

1.3 BBB, BCSFB, and glymphatic system

1.3.1 Blood-CSF-Barrier (BCSFB)

1.3.2 Glymphatic system

1.3.3 Relation between the BBB and glymphatic system

1.4 Key takeaways from Chapter 1

References

Two - Imaging of BBB function and permeability

2.1 Nuclear medicine approaches

2.1.1 Positron Emission Tomography

2.1.2 Single Photon Emission Computed Tomography

2.1.3 Modeling of BBB function and permeability

2.1.3.1 Graphic analysis approaches

2.1.3.2 Nongraphic pharmacokinetic approaches

2.2 X-ray computed tomography

2.3 Contrast-enhanced MRI measurement of BBB permeability

2.4 Noncontrast MRI measurement of BBB water exchange and permeability

2.4.1 Modeling of water exchange and permeability across BBB

2.4.2 Diffusion-weighted ASL for mapping BBB water exchange rate (Kw)

2.4.3 Multi-TE ASL for mapping BBB water exchange rate (Kw)

2.4.4 Whole brain measure of water extraction fraction and permeability

2.5 Relation between contrast and noncontrast BBB imaging

2.6 Key takeaways of Chapter 2

Three - Imaging natural variations of BBB function

3.1 Imaging BBB function with aging

3.1.1 DCE-MRI

3.1.2 PET/SPECT

3.1.3 ASL-based methods

3.2 Sex-dependent BBB variations

3.3 Imaging BBB function variation with circadian rhythm

3.4 Imaging BBB function during sleep

3.4.1 Sleep promotes glymphatic function.

3.4.2 BBB dysfunction associated with sleep disorders

3.5 Key takeaways of Chapter 3

Four - Imaging BBB dysfunction in brain disorders

4.1 Stroke

4.1.1 DCE/DSC MRI of BBB permeability in stroke

4.1.2 Noncontrast MRI of BBB water exchange in stroke

4.1.3 CTP of BBB permeability in stroke

4.2 Alzheimer's disease

4.2.1 DCE MRI of BBB permeability in AD

4.2.2 Noncontrast MRI of BBB water exchange and permeability in AD

4.3 Cerebral small vessel disease (cSVD)

4.3.1 DCE MRI of BBB permeability in cSVD

4.3.2 Noncontrast MRI of BBB water exchange and permeability in cSVD

4.4 Other neurologic disorders: Brain tumor and multiple sclerosis (MS)

4.4.1 Brain tumors

4.4.2 Multiple sclerosis (MS)

4.5 Psychiatric diseases (schizophrenia, depression, etc.)

4.5.1 Schizophrenia spectrum disorder (SDD)

4.5.2 Major depressive disorder (MDD)

4.6 Key takeaways of Chapter 4

Five - Imaging BBB for treating brain disorders

5.1 Therapeutic targets and drug delivery across the BBB

5.1.1 BBB bypass drug delivery

5.1.2 Modification of drugs for BBB transport

5.2 Transit BBB opening using focused ultrasound (FUS)

5.3 Lifestyle, exercise, diet effects on BBB (gut-brain axis)

5.3.1 "Leaky gut, leaky brain"

5.3.2 Potential therapeutic approaches targeting the gut-brain axis

5.4 Key takeaways of Chapter 5

Six - Looking into the future

6.1 Emerging technologies in BBB imaging

6.1.1 Magnetic resonance imaging (MRI)

6.1.2 Positron emission tomography (PET)

6.2 Challenges and opportunities in BBB imaging research

6.3 Key takeaways of Chapter 6

Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

0-443-32975-3

0-443-32974-5

OCLC:

1553758173