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Pathophysiological Consequences of Alcohol.
Elsevier ScienceDirect eBook - Neuroscience and Psychology 2025 Available online
Elsevier ScienceDirect eBook - Neuroscience and Psychology 2025- Format:
- Book
- Series:
- Fundamentals of Physiology Series
- Language:
- English
- Subjects (All):
- Alcoholism.
- Alcohol in the body.
- Physical Description:
- 1 online resource (375 pages)
- Edition:
- 1st ed.
- Place of Publication:
- Chantilly : Elsevier Science & Technology, 2025.
- Summary:
- Pathophysiological Consequences of Alcohol examines the impact of alcohol on physiological processes within various organ systems.The book starts with an introduction to relevant organ system physiology, then presents current, evidence-based findings on how alcohol use, whether acute or chronic, affects these processes.
- Contents:
- Front Cover
- Pathophysiological Consequences of Alcohol
- Copyright
- Contents
- Contributors
- Foreword
- 1 - Overview of pathophysiological effects of alcohol on organ systems
- Introduction
- Drinking patterns
- Alcohol drinking across the life span
- Alcohol metabolism and its contribution to alcohol-associated pathophysiology
- Models used in alcohol research
- Major alcohol-mediated pathophysiological mechanisms contributing to organ injury
- Oxidative stress
- Gut dysbiosis
- Immunomodulation
- Mitochondrial dyshomeostasis
- Cellular death and survival pathways
- Apoptosis
- Necrosis and necroptosis
- Pyroptosis and ferroptosis
- Autophagy
- Endoplasmic reticulum (ER) stress
- Extracellular matrix remodeling
- Stem cell function
- Epigenomic mechanisms
- Summary, perspectives, and practical implications
- References
- Further reading
- 2 - Alcohol and cellular physiology
- Cellular targets of alcohol
- Integrity of the plasma membrane
- Alcohol-induced ROS production and antioxidant capacity
- Effects of alcohol on cellular metabolism and mitochondrial bioenergetics
- Effects of alcohol on protein structure and function
- DNA damage and repair
- Impact of alcohol on lipids and protein homeostasis
- Signal transduction pathways
- Effects of alcohol on lipid metabolism
- Conclusions and future directions
- Clinical vignette
- 3 - Alcohol and neurophysiology
- Overview of nervous system physiology and the primary effects of alcohol
- Normal physiology of the nervous system and the effects of alcohol
- Central nervous system changes
- Peripheral nervous system (PNS) changes
- Functional anatomy of the nervous system and the effects of alcohol
- Central nervous system
- Brain regions vulnerable to alcohol.
- Major cell types and interactions with other systems
- Peripheral nervous system
- Regions vulnerable to alcohol
- Major cell types and interactions with other systems
- Summary
- The impact of chronic, at-risk alcohol use in the exacerbation of mental illness and brain disease
- Alcohol and the cumulative allostatic stress load on body and brain
- Psychiatric disorders
- Neurological disorders
- Clinical vignettes illustrating alcohol's impact on brain health
- Alcohol, aging, and cognitive deficits
- Alcohol use disorder, stress, and pain
- Conclusion
- 4 - Alcohol and cardiovascular and renal physiology
- Overview of cardiovascular physiology
- Alcohol and cardiovascular disease
- The complex relationship between alcohol and heart health
- Potential beneficial effects of alcohol on the heart
- Detrimental effects of alcohol on the heart
- Alcohol-associated cardiomyopathy (ACM)
- Sympathetic nervous system
- Renin-angiotensin-aldosterone system (RAAS)
- Hypertrophy
- Protein turnover
- Mitochondrial dysfunction, oxidative stress, and apoptosis
- Excitation-contraction coupling
- Fibrosis
- Holiday heart syndrome (HHS)
- Hypertension
- Overview of renal physiology
- Alcohol and renal disease
- Acute effects of alcohol on renal function: Diuresis
- Cardiorenal syndrome
- Clinical vignettes
- 5 - Alcohol and respiratory physiology
- Anatomy of the respiratory system
- Mechanics of breathing
- Gas exchange
- Gas transport
- Acid-base balance and control of breathing
- Impact of alcohol on pulmonary physiology
- Effects of alcohol on pulmonary function
- Effects of alcohol on the upper airways/conducting zone
- Effects of alcohol on bronchioles and alveoli
- Alveolar ROS/GSH balance
- Alveolar immunity.
- Alveolar macrophages (AMs)
- Peripheral immune cell recruitment
- Mitochondrial injury and surfactant disruption
- Pulmonary endothelium and vascular remodeling
- Pneumonia
- Acute respiratory distress syndrome (ARDS)
- Sleep-disordered breathing
- Pulmonary fibrosis (emerging association)
- Pulmonary hypertension
- Alcohol, tobacco interaction, and lung cancer
- 6 - Alcohol and gastrointestinal physiology
- Overview of the gastrointestinal tract
- Impact of alcohol on digestion
- Effects of alcohol on the mouth and esophagus
- Effects of alcohol on the stomach
- Effects of alcohol on the small intestine
- Effects of alcohol on the large intestine and the gut microbiome
- Alcohol's impact on the gastrointestinal tract hormone secretion and function
- Effects of alcohol on the rectum
- 7 - Alcohol and liver physiology
- Liver anatomy and function
- Kupffer cells (KCs)
- Hepatic stellate cells (HSCs)
- Liver sinusoidal endothelial cells (LSECs)
- Cholangiocytes
- Alcohol-associated liver disease pathophysiology
- Hepatocytes
- Kupffer cells
- Hepatic stellate cells
- Alcohol interaction with drug metabolism
- Alcohol interaction with viral infections
- Hepatocellular carcinoma (HCC)
- 8 - Alcohol and endocrine physiology
- Possible sites of alcohol-induced endocrine disruption
- Hypothalamus
- Pituitary
- Thyroid gland
- Parathyroid gland
- Pancreas
- Adrenal glands
- Male and female reproductive system
- Impact of alcohol on body composition
- Stress response
- Clinical vignette 1
- Clinical vignette 2
- References.
- 9 - Alcohol and musculoskeletal physiology
- Overview of the musculoskeletal system
- Skeletal muscle physiology
- Bone physiology
- Pathophysiological mechanisms of at-risk alcohol use-mediated muscle adaptations
- Impact of alcohol on muscle structural integrity
- Impact of alcohol on muscle protein homeostasis
- Impact of alcohol on muscle regeneration
- Impact of alcohol on mitochondrial homeostasis
- Impact of alcohol on extracellular matrix (ECM) remodeling
- SKM changes associated with alcohol-related liver disease
- Pathophysiological mechanisms of at-risk alcohol use-mediated bone adaptations
- Alcohol's impact on fracture healing
- Hormone and calcium homeostasis
- Physical frailty and alcohol
- 10 - Integration of pathophysiological effects of alcohol: A convergence factor for comorbid conditions
- Nervous system: Neuroadaptation and co-morbid neurological and psychiatric disorders
- Cardiovascular and renal systems: Hemodynamic instability and end-organ injury
- Pulmonary and musculoskeletal systems: Structural and immune vulnerability
- Liver and gastrointestinal Systems: The gut-liver-inflammation axis
- Endocrine and metabolic systems: Hormonal dysregulation and bioenergetic impairment
- Clinical implications: A call for integrative, system-based care
- Research directions: Priorities for mechanistic and translational studies
- Policy and public health: Reframing alcohol as a multisystem threat
- Index
- Back Cover.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Part of the metadata in this record was created by AI, based on the text of the resource.
- ISBN:
- 9780443342592
- 0-443-34259-8
- 0-443-34258-X
- OCLC:
- 1557282925
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