Organ System Crosstalk in Critical Illness : From Basic Pathophysiology to Clinical Management / edited by Denise Battaglini, Silvia De Rosa, Daniel Agustin Godoy.

Format:

Book

Author/Creator:

Battaglini, Denise.

Series:

Medicine Series

Language:

English

Subjects (All):

Critical care medicine.

Anesthesiology.

Neurology.

Nervous system--Surgery.

Nervous system.

Intensive Care Medicine.

Neurosurgery.

Local Subjects:

Intensive Care Medicine.

Anesthesiology.

Neurology.

Neurosurgery.

Physical Description:

1 online resource (737 pages)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

This book describes deleterious inter-organ crosstalk and its mechanistic concepts, underlying the specific clinical aspect and focusing on medical clinical management in critical care. Homeostasis and health of multicellular organisms with multiple organs depends on inter-organ communication. Tissue injury in one organ disturbs this homeostasis and can lead to disease in multiple organs, or multi-organ failure. Many routes of inter-organ crosstalk during homeostasis are relatively well known, but inter-organ crosstalk in disease still lacks understanding. Particularly, how tissue injury in one organ can drive injury at remote sites and trigger multi-organ failure with high mortality is poorly understood. Mechanistically, inter-organ crosstalk after tissue injury could involve soluble mediators and their target receptors, cellular mediators, in particular immune cells, as well as newly identified neuro-immune connections. The book - addressed to healthcare providers working in intensive care units - aims to provide a comprehensive synthesis and interpretation of organ crosstalk, with a particular focus on continuing practice gaps and areas with new data, to assist clinicians in making practical, yet evidence-based decisions regarding nutrition management during the different stages of critical illness.

Contents:

Part I. General Aspects

1. Organ system crosstalk in critical illness

2. Endocrine emergencies

3. Immune-inflammatory mechanisms in organ crosstalk: rheumatic conditions in Intensive Care Unit

Part II. The Central Nervous System

4. Neuro-immune response and brain-peripheral crosstalk: the role of the complement system

5. New Insights in Septic Encephalopathy

6. Stroke-inflammatory brain blood barrier dysfunction

7. Molecular Crosstalk in Traumatic Brain Injury

8. Melatonin and the brain-heart crosstalk

9. Subarachnoid hemorrhage and system crosstalk

10. Inflammatory mechanisms in Cardiac Arrest

Part III. The Kidneys

11. Molecular mechanisms of kidney crosstalk with distant organs

12. Brain–Kidney Crosstalk in Acute Brain Injury: Understanding Polyuria and Augmented Renal Clearance from Pathophysiology to Clinical Practice

13. Kidney-gut crosstalk in acute kidney injury

14. Myokine mediated muscle-kidney crosstalk

15. Renal disease and neural circuits: brain-kidney crosstalk

16. Cardiorenal Syndromes: Role of Humoral Signalling Cardiorenal Syndromes: Role of Humoral Signalling

Part IV. The Liver

17. Liver-kidney crosstalk: hepato-renal syndrome

18. Gut-liver crosstalk in sepsis-induced liver injury

19. Muscle-liver crosstalk and sarcopenia

20. The liver-organs axis in gastrointestinal and pancreatic acute injury

Part V. The Heart

21. Brain-heart crosstalk: Mechanisms and clinical applications for acute brain injury

22. Metabolic Crosstalk in Heart Failure

23. Detrimental role of humoral signalling in Cardio-renal crosstalk

24. Molecular Imaging of Inflammatory Crosstalk Across the Cardio-renal Axis Following Acute Heart Failure

25. Effects of Atrial Natruretic Peptide on Inter-organ Crosstalk

Part VI. The Lungs

26. Brain-lungs interactions and mechanical ventilation

27. Gut-liver crosstalk in sepsis-induced liver injury

28. Host-microbe crosstalk in the lung microenvironment

29. Lung cell crosstalk in obese patients with ARDS

30. Organ crosstalk in pulmonary hypertension

31. The role of Osteopontin in kidneys and respiratory failure.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

3-032-01024-1

9783032010247

OCLC:

1572212206