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Endothelium and Cardiovascular Diseases : Vascular Biology and Clinical Syndromes.
- Format:
- Book
- Author/Creator:
- Da Luz, Facc.
- Language:
- English
- Subjects (All):
- Endothelium.
- Blood-vessels.
- Physical Description:
- 1 online resource (1957 pages)
- Edition:
- 2nd ed.
- Place of Publication:
- Chantilly : Elsevier Science & Technology, 2025.
- Summary:
- Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes, Second Edition offers new discoveries in clinical settings, cellular, molecular, genetic, and epigenetic mechanisms which have led to novel understanding of the key role of endothelium in both cardiovascular and non-cardiovascular diseases.
- Contents:
- Front cover
- ENDOTHELIUM AND CARDIOVASCULAR DISEASES
- Copyright
- Dedication
- Contents
- Contributors
- About the editors
- Preface
- Reference
- Acknowledgments
- Presentation
- I Structure and Metabolic Functions
- 1 - Signal Transduction Pathways in Endothelial Cells: Implications for Angiogenesis
- Protein Kinases and Protein Phosphatases
- Regulation of Cell Signaling Pathways Depending on Protein Tyrosine Phosphorylation-Protein Tyrosine Phosphatases
- Protein Tyrosine Kinases-Receptor Protein Tyrosine Kinases
- Protein Tyrosine Kinases-Cytoplasmic Protein Tyrosine Kinases
- Signal Transmission-SH2 and SH3 Domains
- Conformational Changes and Posttranslational Modifications in RAS
- RAS Intracellular Compartmentalization
- RAS Signaling Module-ERK1/2 MAP Kinase
- Cellular Signaling in the Endothelium: Angiogenesis and Participation of Nitric Oxide
- Nitric Oxide-Mediated Cellular Signaling in Endothelial Dysfunctions
- References
- 2 - Endothelial Cells in Postcapillary Venules Regulate Plasma Exudation in Inflammatory Diseases and Angiogenesis
- Introduction
- Regulation of Vascular Permeability Through Opening and Closing of Endothelial Adherens Junctions-Main Mechanisms
- β2-adrenergic and cAMP Maintenance of the Endothelial Barrier
- Sphingosine 1-Phosphate (S1P) Stabilization of Endothelial Barrier
- Phosphorylation of VE-Cadherin and Its Relation to Effects on Endothelial Permeability
- Obesity-Induced Inflammatory Changes in the Endothelial Barrier
- Effects of Antioxidants on Ischemia/Reperfusion (I/R) Induced Increase in Vascular Permeability
- Importance of Plasma Leakage at the Tissue Contact Site for Parasites and for Induction of Angiogenesis
- The Transport of Plasma Proteins to the Airway Mucosa Is a Defense Mechanism
- Conclusions
- References.
- Further Reading
- 3 - Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis
- The Endothelium
- Endothelium Shear Stress
- Shear Stress Sensors
- Physiological Responses of Endothelial Cells Under Shear Stress
- Redox Processes in Shear Stress-Induced Signal Transduction in the Endothelium
- Mechanical Response to Cyclic Stretch
- Hemodynamic Forces and Atherosclerosis Pathophysiology
- 4 - Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators
- Endothelium-Dependent Vasodilators
- Nitric Oxide
- NO Reactions: Determinant of its Biological Effects
- Guanylyl Cyclase: An Important Redox Sensor Activated by NO
- Reaction Between NO and Lipid Peroxides: The NO Antioxidant Effect
- Thiol Nitrosation: A New and Important Signaling Effector Mediated by NO
- NO-Superoxide Interaction: The Chemistry of Peroxynitrite and Related Species
- Nitrate and Nitrite: NO Storage Forms
- Nitric Oxide Synthesis Mechanisms
- Mechanisms Regulating eNOS Activation Component
- iNOS and nNOS Regulatory Mechanisms
- Control of NOS Gene Expression
- Mitochondrial NO Synthase
- Cardiovascular Effects of the Different NOS Isoforms: Studies in Genetically Modified Models
- Cofactors of NO Synthase: NO Synthase Uncoupling
- Polymorphisms and Genetic Variations of eNOS and Atherosclerosis
- Nonenzymatic Generation of NO
- EDHFs
- Epoximetabolites of Arachidonic Acid
- Hydrogen Peroxide
- Potassium Ions and Gap Junctions
- Pathological Dysfunction of Endothelium-Dependent Hyperpolarization
- H2S: A New EDRF and EDHF
- Interrelation Between Endothelium-Dependent Vasodilation Mediators
- 5 - Vasoconstrictor Substances Produced by the Endothelium
- How EDCFS are Produced.
- How EDCFS Generate Vasoconstriction
- Endothelium-Derived Contracting Factors
- Prostanoids
- Endothelin-1
- Angiotensin II
- Superoxide Anion
- Conclusions/Perspectives
- 6 - Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease
- What is a Free Radical?
- Biochemical Characteristics of Redox Processes: Radical and Nonradical Pathways
- Antioxidants: The Classical Chemical Concept
- Oxidative Stress and Cellular Redox Signaling: Advancing the Concept
- What is Redox Signaling?
- A Conceptual Redefinition of Antioxidants
- Enzymatic Superoxide Radical Sources in Vessels
- Vascular NADPH Oxidase
- Mitochondrial ROS Production
- Xanthine Oxidase and Oxygenases
- Xanthine Oxidase
- Cyclo and Lipoxygenases
- Cytochrome P450
- Endoplasmic Reticulum and Oxidative Stress
- Redox Processes in Vascular Diseases: Vascular Repair to Injury as an Endothelial/Vascular Pathophysiology Model
- Atherosclerosis, Endothelial Dysfunction, Redox Pathways, and Lipoprotein Oxidation
- NADPH Oxidase in the Pathophysiology of Atherosclerosis
- Mitochondria in the Redox Pathophysiology of Atherosclerosis
- Antioxidants and Atherosclerosis
- Conclusion
- Further Reading
- 7 - The Endothelium and the Immune System
- The Endothelium and the Immune System in an Evolutionary Perspective
- Interactions Between the Endothelium and the Immune System in Physiological Conditions
- Interactions Between the Endothelium and the Immune System in Injury Conditions
- Endothelial Cells and the Immune System in Atherosclerosis
- Endothelial Cells and the Immune System in Arterial Hypertension
- 8 - Progenitor Cells-Origins and Endothelium Regeneration
- Ontogeny of Endothelial Cells
- Markers for Endothelial Progenitor Cells.
- Consensus for the Nomenclature of Endothelial Cells and Progenitors
- Postnatal Angiogenesis
- Endothelial Cells and Clinical Translation
- Regenerative Therapy
- 9 - Blood Coagulation and Endothelium
- Blood Coagulation and Endothelium
- Platelets
- Von Willebrand Factor
- Tissue Factor and Tissue Factor Inhibitor
- Contact System
- Anticoagulant Properties of the Endothelium
- Antithrombin
- Anticoagulant Pathway of Protein C
- Endothelium and Fibrinolysis
- Consequences of Endothelial Dysfunction
- 10 - Platelets and Endothelium
- Platelet Function
- Endothelial Cell Function
- Thrombus Formation
- Pathological Platelet-Endothelium Interaction
- Platelet-Associated Factors
- Endothelium-Associated Factors
- Common Factors
- Future Perspectives
- 11 - Endothelium and Genetics
- Twenty Years After the Conclusion of the Human Genome Project: What Has Changed?
- Main Genes Involved in Endothelial Functions
- Nitric Oxide System
- Endothelial Nitric Oxide Synthase (NOS3)
- Functional Implications of Polymorphisms in the NOS3 Gene
- Clinical Implications of Polymorphisms in the NOS3 Gene
- Arterial Hypertension
- Pregnancy Hypertensive Diseases
- Migraine
- Metabolic Diseases
- Erectile Dysfunction
- Pharmacogenetic Implications of Polymorphisms in the NOS3 Gene
- Arginase I and Arginase II
- Vascular Endothelial Growth Factor
- Asymmetrical Dimethylarginine and its Metabolism Enzyme, Dimethylarginine Dimethylaminohydrolase (DDAH1 and DDAH2)
- Endothelin System
- Inflammatory Mediators
- E Selectin
- What Does Genomic Medicine Hold for the Future of Endothelial Disease Treatment?
- 12 - Regulation of Endothelial Function: With Focus on RNAs, MicroRNAs, and LncRNAs.
- Introduction
- Histone Modification
- DNA Methylation
- Gene Regulation Associated with ncRNAs
- Biogenesis and Function of ncRNAs
- MicroRNA
- Long Noncoding RNA
- Circular RNA
- ncRNAs in the Regulation of Vascular Function: Physiological and Pathological Aspects
- ncRNAs and Endothelial Cells
- ncRNAs and Vascular Smooth Muscle Cells
- ncRNAs as Vascular Injury Biomarkers
- COVID-19-Related ncRNAs
- Potential Role of ncRNAs in Vascular Therapy
- Role of ncRNAs as Pharmacological Therapy in Vascular Diseases
- Modulation of ncRNAs by Physical Activity: A Nonpharmacological Therapy to Treat Cardiovascular Diseases
- 13 - Endothelium and the Renin-Angiotensin System
- Expression of RAS Components on Vasculature
- Vascular Actions of RAS and Cellular Mechanism Involved
- RAS and Endothelial Dysfunction, Atherosclerosis, and Thrombosis
- Angiotensin II Actions
- Angiotensin-(1-7) Counterregulatory Actions
- II Methods of Investigation
- 14 - Methods to Investigate Endothelial Function in Humans
- Evaluation of the Endothelial Function in Humans
- Invasive Methods
- Coronary Arteries-Cineangiography
- Brachial Artery-Plethysmography
- Dorsal Hand Vein-Compliance Technique (Dorsal Hand Vein Technique-DHV)
- Noninvasive Methods
- Artery Diameters-High-Resolution Vascular Ultrasound
- Evaluation of FMD in Other Conductance Arteries
- Passive Leg Movement
- Inhalation CO2 (Hypercapnia) Carotid Diameter Responses
- Peripheral Arterial Tonometry
- Methodology of EndPAT
- Cutaneous Blood Flow with Laser Ultrasound
- Quantification of Substances Produced by the Endothelium in Blood
- 15 - Endothelium to Mesenchymal Transition-Contributions to Vascular Diseases
- Endothelial Cell Plasticity.
- EndoMT Contributes to Fibrosis.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Part of the metadata in this record was created by AI, based on the text of the resource.
- ISBN:
- 0-443-24037-X
- 0-443-24036-1
- OCLC:
- 1559218998
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