Handbook of endocannabinoid function in the central nervous system / Olivier J. Manzoni, Viviana Trezza.

Format:

Book

Contributor:

Manzoni, Olivier J., editor.

Trezza, Viviana, editor.

Series:

Handbook of Behavioral Neuroscience ; Volume 33.

Handbook of Behavioral Neuroscience ; Volume 33

Language:

English

Subjects (All):

Neurophysiology.

Neurosciences.

Physical Description:

1 online resource (0 pages)

Edition:

1st ed.

Place of Publication:

London : Academic Press, 2025.

Summary:

Handbook of Endocannabinoid Function in the Central Nervous System, a new release in the Handbook of Behavioral Neuroscience series, offers a comprehensive, interdisciplinary approach to understanding the role of the endocannabinoid system in functions of the central nervous system.

Contents:

Front Cover

Handbook of Endocannabinoid function in The Central Nervous System

Copyright

Contents

Contributors

Preface

Acknowledgments

1 - History of the endocannabinoid system

1 - The day anandamide almost died, and other endocannabinoid stories

1. The day anandamide almost died

2. A biochemical dilemma

3. A known unknown

4. Conclusions

References

2 - Functional anatomy of the endocannabinoid system

2 - The endocannabinoid signalosome

1. Introduction

2. Endocannabinoids: Biosynthesis and metabolism

3. Anandamide and NAE family

4. 2-Arachidonoylglycerol

5. CB1 and CB2 receptors

6. Signal transduction mechanisms

7. CB1 receptor localization in the brain

8. CB1 receptor in neuronal mitochondria

9. CB1 receptor in astrocytes and astroglial mitochondria

10. CB1 receptor in microglia

11. CB2 receptor

12. Conclusion

3 - Endocannabinoid signaling in glial cells

2. Endocannabinoids target glial cells to modulate brain function

2.1 Glial cells express endocannabinoid-signaling machinery

2.1.1 Astrocytes

2.1.2 Oligodendrocytes

2.1.3 Microglia

2.2 Endocannabinoids shape the homeostatic functions of glial cells

2.2.1 Astrocytic CB1 receptors fine-tune gliotransmission and energy metabolism to modulate behavior

2.2.2 Oligodendrocyte CB1 receptors: Emerging roles in myelin biology

2.2.3 Microglial endocannabinoid signaling in brain physiology: A look back and ahead

3. Deregulation of glial endocannabinoid signaling in neuropathology: Adaptive response or pathogenic mechanism?

4. Concluding remarks

4 - Endocannabinoid in nonneuronal cells of the CNS

1. Introduction.

2. Canonical mechanisms of retrograde eCB signaling

3. Astrocyte responsiveness to eCB signaling

4. eCBs regulation of synaptic transmission via astrocyte activation

5. eCBs control long-lasting synaptic plasticity via astrocyte activation

6. eCBs, astrocytes, and behavior

7. Concluding remarks

Conflict of interest

Author contribution

5 - Cannabinoid modulation of brain mitochondria

1.1 Early evidence of the cannabinoid regulation of mitochondrial functions

1.2 Mitochondrial CB1 receptors in the brain: discovery and location

2. Cannabinoid modulation of cell functions via mitochondrial regulation

2.1 Mitochondrial CB1 receptor modulation of mitochondrial respiration

2.2 Mitochondrial CB1 receptor modulation of glucose metabolism

2.3 Mitochondrial CB1 receptor modulation on Ca2+ dynamics

2.4 Cannabinoid modulation of mitochondrial dynamics

2.5 Cannabinoid modulation of apoptosis

2.6 Local mitochondrial endocannabinoid metabolism

3. Mitochondrial CB1 receptor modulation of synaptic transmission

4. Mitochondrial CB1 receptors modulation of behavior

5. Conclusions and perspectives

3 - The neurophysiology of the endocannabinoid system

6 - Cellular effects of endocannabinoids in the CNS

2. Establishing specificity in cannabinoid cell signaling studies

3. Basics of receptor signaling

4. Canonical cannabinoid receptor signaling

5. CB1 cannabinoid receptors

6. CB2 receptors

7. Noncanonical cannabinoid-engaging GPCRs

8. Direct targeting of ion channel by cannabinoids

9. TRPV1

10. GABA-A receptors

11. Glycine receptors

12. Peroxisome proliferator-activated receptors

13. Conclusion

7 - The endocannabinoid-mediated control of neuronal excitability.

1. Introduction: Endocannabinoid function in the healthy and diseased brain

1.1 Physiological role of endocannabinoids

1.2 The role of endocannabinoids in brain diseases

2. Modulation of brain ion channels by eCBs

2.1 Voltage-gated sodium (Nav) channels

2.2 Voltage-gated calcium (Cav) channels

2.3 Voltage-gated potassium (Kv) channels

2.4 Inward rectifying potassium channels (Kir)

2.5 Hyperpolarization-activated cyclic nucleotide-gated cationic channels

2.6 Two-pore-domain (2P) K+ channels

2.7 Calcium- and sodium-activated potassium channels

3. Intrinsic plasticity and endocannabinoids

4. Conclusion

8 - Potential mechanisms of endocannabinoid release

1. Introduction and background

2. Potential mechanisms of eCB release

2.1 Proteins that bind eCBs

2.2 eCBs and midbrain dopamine neurons

2.3 Synucleins and control of eCB release

2.4 Extracellular vesicles and eCB release

2.5 Mechanisms controlling EV release

3. Conclusions and future directions

Funding

9 - Endocannabinoids in pain modulation

1.1 The problem with pain: Persistence and plasticity

1.2 Cannabis and pain: A potted history

2. Pain and pain pathways

2.1 The endocannabinoid system in pain pathways

2.2 ECs as endogenous modulators of acute pain

2.2.1 Peripheral mechanisms

2.2.2 Spinal mechanisms

2.2.3 Supraspinal mechanisms

2.2.4 Stress, endocannabinoids, and pain

2.3 Endocannabinoid ubiquity, promiscuity, and pain

2.4 Dynamic changes to EC system in models of chronic pain

3. Targeting the EC system for pain relief

3.1 Cannabinoid analgesia

3.2 Blockade of EC metabolism as an analgesic strategy

3.2.1 Fatty acid amide hydrolase inhibition

3.2.2 FAAH-OUT

3.2.3 Monoacylglycerol lipase inhibition.

3.2.4 Recent developments in EC metabolic inhibitors

3.3 Allosteric modulation

3.3.1 CB1R-positive allosteric modulators

3.3.2 CB1R-negative allosteric modulators

4. Sex differences in EC system and pain

5. Summary and future directions

10 - Endocannabinoid regulation of hippocampal circuits

1. INTRODUCTION

2. EXPRESSION OF CB1 RECEPTORS IN THE HIPPOCAMPUS

3. ENDOCANNABINOID CONTROL OF HIPPOCAMPAL NEURONAL CIRCUITS

3.1 Retrograde endocannabinoid signaling mediates short-term and long-term synaptic plasticity

3.2 Nonretrograde endocannabinoid signaling

3.3 Endocannabinoid-mediated communication between neurons and glia

3.4 Tonic endocannabinoid signaling

4. THE ROLE OF THE ENDOCANNABINOID SYSTEM IN HIPPOCAMPAL-DEPENDENT FUNCTION

5. CONCLUDING REMARKS

11 - Endocannabinoids regulation of the mesolimbic system

1.1 Overview of the mesolimbic dopamine system

1.2 Relevance to reward, motivation, and psychiatric disorders

2. Anatomy and functions of the mesolimbic DA system

2.1 Structure

2.1.1 Ventral tegmental area

2.1.2 Nucleus accumbens

2.1.3 Prefrontal cortex

2.2 Functions

2.2.1 Reward processing

2.2.2 Motivation

2.2.3 Learning

2.2.4 Addiction

3. Architecture of the ECB system in the mesolimbic DA system

3.1 Overview of CB1 receptors in the VTA-NAc circuit

3.2 Endocannabinoids and their role in synaptic modulation

3.2.1 Anandamide

3.2.2 2-Arachidonoylglycerol

3.2.3 Synaptic connections and modulation

4. Endocannabinoid modulation of the mesolimbic system in key behaviors

4.1 Natural reward: Impact on dopamine release and reward reinforcement

4.2 Drug addiction: Role in substance use disorders and neural adaptations.

4.3 Social interaction: Influence on social behavior and implications for autism spectrum disorder

4.4 Sensorimotor gating: Modulation of sensorimotor gating and relevance to schizophrenia and obsessive-compulsive disorder

5. Conclusion

12 - Endocannabinoid regulation of cortical functions

2. Molecular composition of cortical endocannabinoid signaling

3. Cannabinoid receptor distribution in the neocortex

4. Cannabinoid receptor-expressing interneurons

5. Endocannabinoid signaling through astrocytes

6. Neocortex neuronal activity

7. Synaptic plasticity in cortex

8. Critical period plasticity

9. Prefrontal cortex

10. Conclusions

13 - The endocannabinoidome and its role in the central and peripheral control of food intake

1. From the endocannabinoid system to the endocannabinoidome

2. Endocannabinoidome control of neurotransmitter release and neuroinflammation in a nutshell

3. The alteration of the endocannabinoidome in human obesity and its association with body mass index, adiposity, eating disor ...

4. The potential role of the milk endocannabinoidome in setting the suckling response

5. Central endocannabinoidome control of food intake

5.1 Evolutionary considerations

5.2 Novel mechanisms underlying central endocannabinoidome-mediated control of food intake

5.2.1 Relationships with leptin

5.2.2 Role of reactive oxygen species

5.2.3 Role of PPARα

5.2.4 Role of TRPV1

5.2.5 Role of GPR55

5.2.6 Role of proopiomelanocortin-expressing neurons

5.2.7 Food deprivation- and obesity-related rewiring of hypothalamic appetite-controlling neurons

6. Peripheral endocannabinoidome control of food intake

6.1 Role of the gut in endocannabinoidome control of food intake

6.1.1 CB1 signaling, the vagus nerve, and cholecystokinin.

6.1.2 Role of PPARα in the gut.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

0-443-13909-1

0-443-13908-3

9780443139093

OCLC:

1550760960