Biomolecular Feedback Systems / Richard M. Murray, Domitilla Del Vecchio.

Format:

Book

Author/Creator:

Del Vecchio, Domitilla, author.

Murray, Richard M., author.

Language:

English

Subjects (All):

Biological control systems.

Systems biology.

Physical Description:

1 online resource (287 p.)

Edition:

Course Book

Place of Publication:

Princeton, NJ : Princeton University Press, [2014]

Language Note:

English

Summary:

This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu

Contents:

Frontmatter

Contents

Preface

Chapter 1. Introductory Concepts

Chapter 2. Dynamic Modeling of Core Processes

Chapter 3. Analysis of Dynamic Behavior

Chapter 4. Stochastic Modeling and Analysis

Chapter 5. Biological Circuit Components

Chapter 6. Interconnecting Components

Chapter 7. Design Tradeoffs

Bibliography

Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

CC BY-SA

Description based on online resource; title from PDF title page (publisher's Web site, viewed 23. Mai 2019)

ISBN:

9781400850501

1400850509

OCLC:

890441141