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Tietz Textbook of Laboratory Medicine / Nader Rifai [and four others].
- Format:
- Book
- Author/Creator:
- Rifai, Nader, author.
- Language:
- English
- Subjects (All):
- Molecular diagnosis.
- Clinical chemistry--Methods.
- Clinical chemistry.
- Diagnosis, Laboratory.
- Physical Description:
- 1 online resource : illustrations (chiefly color)
- Edition:
- Seventh edition.
- Place of Publication:
- St. Louis, Missouri : Elsevier, [2023]
- Summary:
- Use THE definitive reference for laboratory medicine and clinical pathology!Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests.
- Contents:
- Front cover
- Inside front cover
- Front matter
- Tietz Textbook of Laboratory Medicine
- Copyright
- Dedication
- Preface
- Textbook Associate Editors
- Textbook Reviewers
- Textbook Contributors
- Textbook Contents
- Section I: Basics of laboratory medicine, 1
- Section II: Analytical techniques, 200
- Section III: Clinical chemistry-analytes, 348
- Section IV: Clinical chemistry-pathophysiology, 457
- Section V: Genetic metabolic disorders, 886
- Section VI: Molecular diagnostics, 889
- Section VII: Hematology and coagulation, 1035
- Section VIII: Microbiology, 1145
- Section IX: Transfusion medicine, 1252
- Section X: Clinical immunology, 1278
- Appendices
- Multimedia &
- Educational Resources Associate Editors
- Educational Resources Contributors
- Educational Resources Contents
- Adaptive Learning Editors
- Editors-in-chief
- Editors
- Adaptive Learning Courses Contents
- Basics of laboratory medicine
- Analytical techniques
- Clinical chemistry
- Genetic metabolic disorders
- Laboratory genomics
- Hematology &
- coagulation
- Clinical microbiology
- Transfusion medicine
- Clinical immunology
- Section I Basics of Laboratory Medicine
- 1 Laboratory medicine
- Abstract
- Background
- Content
- Introduction
- Looking back
- Training in laboratory medicine
- Expanding boundaries defined by technology
- How is laboratory medicine practiced?
- Guiding principles of practicing the profession
- Confidentiality of patient information
- Allocation of resources
- Codes of conduct
- Publishing issues
- Conflicts of interest
- What is in this textbook?
- Multiple choice questions
- Selected references
- References
- 2 Statistical methodologies in laboratory medicine
- Assay selection overview.
- Medical need and quality goals
- Analytical performance criteria
- Other criteria
- Basic statistics
- Frequency distribution
- Population and sample
- Probability and probability distributions
- Parameters: Descriptive measures of a population
- Statistics: Descriptive measures of the sample
- Random sampling
- The gaussian probability distribution
- Student t probability distribution
- Nonparametric statistics
- Categorical variables
- Technical validity of analytical assays
- Calibration
- Trueness and accuracy
- Precision
- Example
- Precision profile
- Linearity
- Analytical measurement range and limits of quantification
- Analytical sensitivity
- Analytical specificity and interference
- Qualitative methods
- Diagnostic accuracy measures
- Agreement between qualitative tests
- Assay comparison
- Basic error model
- Measured value, target value, modified target value, and true value
- Calibration bias and random bias
- Assay comparison data model
- Comparison of a routine assay with a reference measurement procedure
- Comparison of two routine assays
- Preliminary practical work in relation to a method comparison study
- Planning a method comparison study
- Distribution of differences plot
- Nonparametric approach
- Parametric approach
- Relative distribution of differences plot
- Verification of distribution of differences in relation to specified limits
- Difference (Bland-Altman) plot
- A caution against incorrect interpretation of paired t-tests in method comparison studies
- Regression analysis
- Error models in regression analysis
- Deming regression analysis and ordinary least-squares regression analysis (constant standard deviations)
- Computation procedures for ordinary least-squares regression and deming regression.
- Evaluation of the random error around an estimated regression line
- Interpreting SDy·x (SD21) with random errors in both x1 and x2
- Assessment of outliers
- The correlation coefficient
- Regression analysis in cases of proportional random error
- Testing for linearity
- Nonparametric regression analysis (passing-bablok procedure)
- Interpretation of systematic differences between methods obtained on the basis of regression analysis
- Example of application of regression analysis (weighted deming analysis)
- Discussion of application of regression analysis
- Monitoring serial results
- Traceability and measurement uncertainty
- Traceability
- The uncertainty concept
- The standard uncertainty (Ust)
- Example of direct assessment of uncertainty on the basis of measurements of a commutable certified reference material
- Example of direct assessment of uncertainty on the basis of a method comparison study with a reference measurement procedure using patient samples
- Indirect evaluation of uncertainty by quantification of individual error source components
- Example.
- Uncertainty in relation to traditional systematic and random error classifications
- Diagnostic accuracy of laboratory testsaaThis section relies on three published papers.
- Diagnostic accuracy of a test in isolation
- Diagnostic accuracy, sensitivity, and specificity
- Confidence intervals of diagnostic accuracy, sensitivity, and specificity
- Clinical example: Accuracy of D-dimer test in diagnosis of deep venous thrombosis
- Receiver operating characteristic curves
- Selection of cutoff value in case of quantitative index tests
- Posterior probabilities (predictive values)
- Likelihood ratios and odds ratios
- Comparison of diagnostic accuracy of two tests in isolation
- Shortcomings of diagnostic accuracy studies of tests in isolation.
- Diagnostic accuracy of a test in the clinical context
- Clinical example: Added value of d-dimer testing in the diagnosis of suspected deep venous thrombosis
- Diagnostic accuracy of combinations of diagnostic tests: Receiver operating characteristic area
- Reclassification measures
- Predictiveness curve
- Decision curve analysis
- Test evaluation beyond diagnostic accuracy
- How does testing yield health(care) benefits?
- The working pathway
- Comparative tests: Treatment studies to quantify the impact of tests
- Linked-evidence approaches to quantify the impact of tests
- 3 Governance, risk, and quality management in the medical laboratory
- Purpose and scope of a medical laboratory
- Defining quality in the medical laboratory
- Evolution of the approach to quality management
- Clinical governance, benchmarking, and risk management
- Governance
- Benchmarking
- Risk management
- Risk identification
- Analysis of risk
- Risk mitigation
- Integrating risk and quality management
- Quality management systems
- Standards and guidelines for the medical laboratory
- Clinical and laboratory standards institute-quality management systems guidelines
- Quality management systems and the process model
- ISO 15189 and clinical and laboratory standards institute-quality system essential compared
- The key components of quality management systems for medical laboratories
- Management responsibility
- Accreditation or certification?
- Accreditation and regulation of medical laboratories
- An international model
- Alternative models
- Approaches to quality management
- Principles of quality management
- Customer focus
- Process approach
- Systems approach to management
- Continual improvement.
- Factual approach to decision making
- Measures and quality indicators.
- Understanding variation.
- Cost of quality (including waste).
- Nonconforming events and risk management.
- Mutually beneficial supplier relationships
- Summary of useful quality management tools and resources
- Organizational quality and business excellence frameworks
- 4 Specimen collection and processing
- Patient identification
- Types of specimens
- Blood
- Venipuncture
- Preliminary steps.
- Timing.
- Location.
- Preparation of the site.
- Venous occlusion.
- Order of draw for multiple blood specimens.
- Collection with evacuated blood tubes.
- Blood collection with a syringe.
- Completion of collection.
- Venipuncture in children.
- Skin puncture
- Arterial puncture
- Anticoagulants and preservatives for blood
- Heparin.
- Ethylenediaminetetraacetic acid.
- Sodium fluoride.
- Citrate.
- Acid citrate dextrose.
- Oxalates.
- Iodoacetate.
- Influence of site of collection on blood composition
- Collection of blood from intravenous or arterial lines
- Hemolysis
- Urine
- Timed urine specimens
- Collection of urine from children
- Urine preservatives
- Stool
- Other body fluids
- Bronchoalveolar lavage
- Chorionic villus sampling
- Buccal cells
- Solid tissue
- Hair and nails
- Handling of specimens for analysis
- Maintenance of specimen identification
- Preservation of specimens
- Add-on requests
- Separation and storage of specimens
- Transport of specimens
- Conclusion
- 5 Preanalytical variation and pre-examination processes
- Historical perspective
- The preanalytical phase today.
- Influencing and interference factors.
- Notes:
- Preceded by: Tietz textbook of clinical chemistry and molecular diagnostics. Sixth edition. St. Louis, Missouri : Elsevier, [2018]
- Includes bibliographical references.
- Description based on print version record.
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 0-323-83467-1
- OCLC:
- 1378390863
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