Biophysical theory of radiation action : a treatise on relative biological effectiveness / Klaus Günther, Wolfgang Schulz.

Format:

Book

Author/Creator:

Günther, Klaus, author.

Schulz, Wolfgang, author.

Language:

English

Subjects (All):

Radiation.

Physical Description:

1 online resource (368 pages)

Edition:

Reprint 2022

Place of Publication:

Berlin : De Gruyter, [2022]

Contents:

Frontmatter

Preface

Contents

Chapter 1 Review of theoretical conceptions

1.1. Introduction

1.2. Classical target theory

1.3. The LET concept

1.4. Microdosimetry

1.5. Gross sensitive volume with structure

1.6. Some descriptive approaches to survival curves and RBE

Chapter 2 An approximate approach based on microdosimetry

2.1. Introduction

2.2. Formalism of the microdosimetric version of theory

2.3. Theoretical consequences for the relative biological effectiveness

2.4. Analysis of experimental data

2.5. Primary lesions and the relevant RBE

2.6. Appendix

Chapter 3 The mathematical formalism of the DNA-lesion theory of radiation action

3.1. Introduction

3.2. Prerequisites and basic principles of approximation

3.3. Description of radiation fields

3.4. Description of absorption events

3.5. The model of DNA-lesion production

3.6. The theory of cellular radiation effects

3.7. Formal properties and consistency of the theory

3.8. Appendix: estimation of errors

Chapter 4 The underlying physical relationships

4.1. Introduction

4.2. Linear energy transfer

4.3. Energy spectrum of 8-rays

4.4. Primary ionizations and ionization cluster frequencies

4.5. Electron range

4.6. Secondary electron spectrum of photon radiation

4.7. Secondary charged particle spectra of fast neutrons

Chapter 5 Implications concerning microdosimetry

5.1. Introduction

5.2. The mathematical formalism

5.3. Comparison with experimental data

Chapter 6 Evaluation of the model of DNA-lesion production

6.1. Introduction

6.2. Methodic particulars

6.3. General results

6.4. DNA-strand breaks

Chapter 7 Mammalian cell killing

7.1. Introduction

7.2. Survival curve analysis for monoenergetic ion radiations

7.3. Ion radiations

7.4. Fast neutron radiations

Chapter 8 Re-formulation of the theory

8.1. Introduction

8.2. Virtual mierodosimetry

8.3. The ultimate general formalism of the theory of cellular radiation effects

8.4. Evaluation of RBE in LETapproximation for monoenergetic ions

Chapter 9 Concise instructions for practical calculations

9.1. Introduction

9.2. Calculation of dose-effect relations

9.3. Expressing a dose-effect relation by a sum of exponential functions

Appendix

References

Subject index

Notes:

Description based on: online resource; title from PDF information screen (De Gruyter, viewed December 7, 2022).

ISBN:

3-11-261894-7

OCLC:

1338019215