Vitamin D : a pluripotent steroid hormone : structural studies, molecular endocrinology, and clinical applications : proceedings of the ninth Workshop on Vitamin D, Orlando, Florida (USA), May 28-June 2, 1994 / Editors: A. W. Norman ; R. Bouillon ; M. Thomasset.

Format:

Book

Conference/Event

Contributor:

Norman, Anthony W., editor.

Bouillon, R., editor.

Thomasset, Monique, editor.

Conference Name:

Workshop on Vitamin D (9th : 1994 : Orlando, Fla.)

Language:

English

Subjects (All):

Vitamin D--Therapeutic use.

Vitamin D.

Physical Description:

1 online resource (966 p.)

Edition:

Reprint 2020

Place of Publication:

Berlin, Germany ; New York, New York : Springer-Verlag, [1994]

Language Note:

In English.

Summary:

The proceedings of the May-June 1994 workshop comprise technical papers in: chemistry of vitamin D, structure/function studies of vitamin D steroids, vitamin D binding protein, vitamin D hydroxylases--biochemistry and regulation, vitamin D metabolism and catabolism, receptors for 1,25(OH)2D3, gene regulation, rapid actions of vitamin D steroids, calbindins D--function and gene regulation--calcium transport, cell differentiation, cancer, immunology, dermatology, neurosciences, renal osteodystrophy, bone and cartilage, miscellaneous biological actions of vitamin D metabolites and analogs, assays for vitamin D steroids, nutrition, osteoporosis, neonatology and pregnancy, gerontology, other basic science topics, and other clinical topics. Annotation copyright by Book News, Inc., Portland, OR

Contents:

Vitamin D

Frontmatter

FOREWORD

Official Sponsors and Donors

YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D

Vitamin D Workshop. Career Recognition Awardees

Contents

Chemistry of Vitamin D

Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation

Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships

Chemical Conversion of Vitamin D3 to Calcitriol Lactone

Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol

A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses

Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs

Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions

Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers

Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs

Metallic Complexes of Hydroxylated Derivatives of Vitamin D3

A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3

Structure-Activity Studies of Fluorinated Vitamin D Analogs

An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion

Synthesis of 24-Hydroxy-Vitamin D Analogues

Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3

A New Route to the Vitamin D Triene System

Studies on the Synthesis of 19-Norprevitamin D3 Analogues

Structure/Function Studies of Vitamin D Steroids

The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications

Future Prospects for Vitamin D Analogs

Chemistry and Biology of 22,23-yne Analogs of Calcitriol

Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity

Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells

Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs

Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues

Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton

Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto

New Discoveries in Vitamin D Related Compounds

Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility

Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region

Synthesis and Biological Activity of 23-oxa Vitamin D Analogues

Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues

20-Methyl Vitamin D Analogues

2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results

Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs

Vitamin D Binding Protein

Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues

Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum

Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues

Vitamin D Hydroxylases: Biochemistry and Regulation

Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine

Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase

Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain

Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene

IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats

In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1

The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver

Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria

The Kinetics of Monocyte la-Hydroxy läse in Uremia.

Modulation by Calcitriol and 25(OH)D3 Therapy

Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis

25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients

Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1)

Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats

Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate

Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues

Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase

Vitamin D Metabolism and Catabolism

Target Cell Metabolism of Vitamin D and its Analogs

In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin

Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes

Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells

Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82

The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3

Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate

The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney

Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes

Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific

Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line

22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells

Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells

Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes

Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry

Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs

24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts

Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta

Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny

Receptors for 1a,25(OH)2D3

Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation

Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization

The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone

Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D

Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers

Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription

Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements

Immunohistochemical Localization of

1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas

Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8)

Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats

A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization

Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library

Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor

EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type

Gene Regulation

1,25(OH)2D3 Response Elements: Is There an Order?

Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation

Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3

Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements

Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses

A Novel Vitamin D Response Element in the Murine c-fos Promoter

1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines

1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA)

Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein

Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo

Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells

Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells

TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription

Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines

mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin

Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different

Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3

Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene

Rapid Actions of Vitamin D Steroids

Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts

Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences

Nongenomic Effects of Vitamin D

Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3

A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol

The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells

Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei

1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes

Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3

Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3

Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts

Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells

Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes

Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes

Calbindins D—Function and Gene Regulation: Calcium Transport

Mechanistic Studies on Intestinal Ca2 + Transport

Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins

Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones

Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor

Studies of the Human Calbindin-D9K Gene

Calbindins Revisited in the Rat Dental Pulp

In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts

Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture

Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells

Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC)

Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs

EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells

Does Calbindin-D28K Buffer Intracellular Free Calcium?

Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3

Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells

Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K

Effect of Antisense Sequences Against Calretinin on WiDr Cells

Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment

Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua

Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption

1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms

Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum

Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney

Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat

Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker

Cell Differentiation

In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines

Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis)

1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro

Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects

Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation

Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts

Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß

Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell

Differentiation

1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts

1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices

Cancer

Immunology

Dermatology

Neurosciences

Renal Osteodystrophy

Bone and Cartilage

Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs

Assays for Vitamin D Steroids

Nutrition

Osteoporosis

Neonatology and Pregnancy

Gerontology

Other Basic Science Topics

Other Clinical Topics

Author Index

Subject Index

Cell Line Index

Zoo Index

Backmatter

Notes:

Description based on print version record.

ISBN:

3-11-088251-5

OCLC:

1202624475