Flavins and Flavoproteins 1987 : Proceedings of the Ninth International Symposium, Atlanta, Georgia, USA, June 7-12, 1987 / D. E. Edmondson, D. B. McCormick.

Format:

Book

Contributor:

Edmondson, D. E., editor.

McCormick, D. B., editor.

Language:

English

Subjects (All):

Flavoproteins.

Flavins.

Physical Description:

1 online resource (804 pages)

Edition:

Reprint 2019

Place of Publication:

Berlin ; Boston : De Gruyter, [2019]

Language Note:

In English.

Summary:

Proceedings of the Ninth International Symposium held at Emory University, Atlanta, June 1987 offer a state-of-the-art survey of the subject. Major topics include: structure and mechanism of flavoenzymes; flavoenzyme hydroxylases; flavin-dependent bioluminescence; and structure, mechanism, and biosynthesis of flavoenzymes containing covalently-bound flavins. The diversity manifested here reflects a "maturation" of the field. A broad approach to the fundamental question of how flavoenymes work is evident by the combined efforts of x-ray crystallography, NMR spectroscopy, site- directed mutagenesis, in conjunction with more "classical" kinetic and mechanistic experiments. The field of flavin enzymology is embarking on a new era where molecular insights into structure and function will be of enormous benefit for a wide variety of biological and biomedical disciplines; ranging from neurochemistry to environmental detoxification. Annotation copyrighted by Book News, Inc., Portland, OR

Contents:

Mechanism of ferredoxin-NADP+ reductase reaction NADP radical, semiquinone and fully reduced enzyme-NADP+ charge transfer complex as the reaction intermediates / Yoshikawa, Shinya / Nitta, Satoshi / Nishiyama, Kyoko / Ohnishi, Norihiro / Takeshima, Katsuhito / Ishii, Yasuhiko / Nakamura, Makoto / Matsuara, Hiroshi / Kodo, Keiun

In vivo deactivation/activation of ferredoxin-NADP+- oxidoreductase from the cyanobacteria Anabaena variabills / Fillat, M. F. / Gómez-Moreno, C.

Isolation from Desulfovibrio desulfuricans of a flavoprotein with NADH-H+ oxidoreductase activity towards a protein containing a rubredoxin-like center / Saint-Martin, P. / Galliano, N. / Fauque, G. / Moura, I. / Moura, J. J. G. / LeGall, J.

Microsomal electron transport system focused on NADPH-cytochrome P-450 reductase / Nisimoto, Y.

Time - resolved fluorescence spectroscopy on NADPH-cytochrome P-450 reductase / Bonants, Peter / Bastiaens, Phil / Visser, Ton / Miiller, Franz

Studies on the reactions of flavin- and nicotinamide nucleotide analogues with a bacterial electron-transferring flavoprotein / O'Nuallain, Eoin M. / Mayhew, Stephen G.

Kinetics of ligand binding, amino acid sequence, and crystallization of Chlorobium and Chromatium flavocytochrome c. / Meyer, T. E. / Holden, H. M. / Rayment, I. / Bartsch, R. G. / Cusanovich, M. A. / Van Beeumen, J.

Redox properties of flavocytochrome c. / Cusanovich, M. A. / Bartsch, R. G. / Meyer, T. E.

Electron transfer kinetics of phthalate oxygenase reductase, an iron sulfur center containing flavoprotein / Batie, Christopher J. / Ballou, David P.

CD and potentiometry of the FAD of nitrate reductase / Barber, M. J. / Kay, C. J. / Solomonson, L. P.

Kinetic studies on glutamate synthase from Azospirillum bras ilense / Ratti, S. / Vanoni, M. A. / Grandori, R. / Zanetti, G. / Curti, B.

Redox interactions of the FAD in xanthine oxidase with other centers of the protein / Hille, Russ

Laser flash photolysis studies of intramolecular electron transfer between the FAD and Fe/S II centers in xanthine oxidase / Edmondson, Dale E. / Hazzard, James T. / Tollin, Gordon

Mechanism of action of chicken liver xanthine dehydrogenase / Nishino, Takeshi / Tsushima, Keizo / Schopfer, Lawrence M. / Massey, Vincent

Interconversion between O-dependent and NAD - dependent types of rat liver xanthine dehydrogenase / Saito, T. / Nishino, T. / Tsushima, K.

Reactivity of chicken liver xanthine dehydrogenase containing artificial flavins / Nishino, Tomoko / Nishino, Takeshi / Tsushima, Keizo / Schopfer, Lawrence M. / Massey, Vincent

The molybdenum cofactor of milk xanthine oxidase / Fish, Kenneth M. / Massey, Vincent

Isolation of a cDNA sequence coding for a part of xanthine dehydrogenase from rat liver / Yamazaki, K. / Nishino, T. / Tsushima, K.

FLAVIN BIOSYNTHESIS/ METABOLISM/ AND MEDICAL ASPECTS

Biosynthesis of flavins and deazaflavins / Bacher, Adelbert / Volka, Rainer / Keller, Paul J. / Floss, Heinz G. / Le Vana, Quang / Eisenreich, Wolfgang / Schwarzkopf, Bruno

The icosahedral ß60 capsid of heavy riboflavin synthase (6,7- dimethyl-8-ribityllumazine synthase/riboflavin synthase) / Ladensteina, Rudolf / Hubera, Robert / Schott, Karin / Schneider, Monika / König, Astrid / Bacher, Adelbert

Characterization of human riboflavin-binding immunoglobulins / Merrill, A. H. / Innis-Whitehouse, W. S. A. / McCormick, D. B.

Riboflavin uptake by isolated rat kidney cells / Bowers-Komro, Delores M. / McCormick, Donald B.

Purification and characterization of the bifunctional enzyme FAD synthetase from Brevibacterium ammoniapenes / Manstein, Dietmar J. / Pai, Emil F.

An update on flavin metabolism in rats and humans / McCormick, D. B. / Innis, W. S. A. / Merrill, A. H. / Bowers-Komro, D. M. / Oka, M. / Chastain, J. L.

Effects of quinacrine, tetracycline, adriamycin and chloroquine upon flavin metabolism in rats / Dutta, P. / Pinto, J. T. / Kaiczyk, G. B. / Rivlin, R. S.

Role of flavoproteins in the neurotoxic action of MPTP / Singer, Thomas P. / Ramsay, Rona R.

Biosynthesis of flavoproteins / Yagi, Kunio / Inagaki, Taisuke / Ichihara, Chikako / Koshizaka, Takuya / Ohishi, Nobuko / Ghisla, Sandro / Tsukagoshi, Norihiro / Udaka, Shigezo / Nishikimi, Morimitsu / Ozawa, Takayuki

Biological and Medical Aspects of D-Amino Acid Oxidase - Biogenesis and in vivo reaction with D-propargylglycine - / Miyake, Yoshihiro / Fukui, Kiyoshi / Momoi, Kyoko / Watanabe, Fusao / Shibata, Toshihiro

Molecular and cellular biology of D-amino acid oxidase / Fukui, Kiyoshi / Watanabe, Fusao / Shibata, Toshihiro / Momoi, Kyoko / Miyake, Yoshihiro

Localization of D-amino acid oxidase in rat cerebellum / Horiike, Kihachiro / Tojo, Hiromasa / Aral, Ryohachi / Yamano, Toshio / Nozaki, Mitsuhiro / Maeda, Toshihiro

Biosynthesis of D-amino acid oxidase and molecular cloning of the cDNA / Inagaki, Taisuke / Ohishi, Nobuko / Koshizaka, Takuya / Chikako, Chikako / Yagi, Kunio / Tsukagoshi, Norihiro / Udaka, Shigezo

Characterization of a partially purified nitroaryl reductase / Bryant, Christopher / Martin, Tracy / DeLuca, Marlene

FLAVOENZYME HYDROXYLASES

Crystallographic studies on the mechanism of hydroxybenzoate hydroxylase from Psudomonas fluorescens / Schreuder, Herman A. / Laan, Jan M. van der / Thunnissen, Marjolein M. G. M. / Kalk, Kor H. / Swarte, Myra B. A. / Hoi, Wim G. J. / Drenth, Jan

Applications of deuterium and tritium isotope effects to the elucidation of kinetic mechanisms of flavoprotein hydroxylases / Tu, Shiao-Chun / Wang, Lee-Ho / Yu, Yimin

Chemical modification of tyrosine-38 in j>.-hydroxybenzoate hydroxylase from Pseudomonas fluorescens by 5'-Pfluorosulfonylbenzoyladenosine: A probe for the elucidation of the NADPH binding site? / Berkel, Willem J. H. van / Bakx, Edwin J. / Miiller, Franz / Weyer, Wicher J. / Jekel, Peter A. / Beintema, Jaap J. / Schreuder, Herman A. / Laan, Jan M. van der / Wierenga, Rik K. / Drenth, Jan / Hol, Win G. J.

Phenol Complexes of Phenol Hydroxylase / Sejlitz, Torsten / Neujahr, Haiina Y.

The involvement of SH-groups in cooperativity of phenol binding sites in phenol hydroxylase / Neujahr, Halina Y.

6-Thiocyanate-FAD and 6-mercapto-FAD as active site probes of phenol hydroxylase / Taylor, M. G. / Massey, V.

Hysteretic behavior of anthranilate hydroxylase / Powlowski, Justin / Ballou, David / Massey, Vincent

Redox potentials of salicylate hydroxylase / Einarsdottir, G. H. / Stankovich, M. T. / Wang, L.-H. / Tu, S.-C.

The oxidative half-reaction of 2-methyl-3-hydroxypyridine-5 - carboxylic acid oxygenase from Pseudomonas sp. MA-1 / Brissette, Pierre / Ballou, David P. / Massey, Vincent

Lipid stabilization of the flavin hydroperoxide in the microsomal flavin-containing monooxygenase / Poulsen, L. L. / Nagata, T. / Taylor, K. L.

FLAVIN-DEPENDENT BIOLUMINESCENCE

One-electron transfers in flavin systems: Relevance to the postulated C1EEL mechanism in bacterial bioluminescence / Mager, Humphrey I. X. / Tu, Shiao-Chun

Characterization of new "bleached" products obtained on treating flavins and flavoproteins with dithionite / Mager, Humphrey I. X.

Flavin-mediated hydrogen peroxide production by biological and chemical photosystems / De la Rosa, M . A . / Heelis, P. F. / Rao, K. K. / Hall, D. O.

On the chemical mechanisms of bacterial luciferase, an updating / Ghisla, Sandro / Eckstein, Jens / Macheroux, Peter

Studies on the mechanism of bacterial bioluminescence. Evidence compatible with a one electron transfer process and a CIEEL mechanism in the luciferase reaction / Macheroux, Peter / Eckstein, Jens / Ghisla, Sandro

Structural analysis of bacterial luciferase / Baldwin, T. O. / Chen, L. H.

/ Chlumsky, L. J. / Devine, J. H. / Johnston, T. C. / Lin, J.-W. / Sugihara, J. / Waddle, J. J. / Ziegler, M. M.

Sequence similarity between the a subunit of luciferase from Vibrio harvevl and clostridial flavodoxin / Murata, M. / Lee, John

Isolation and characterization of a yellow fluorescent protein from Vibrio fischeri strain Y-1 / Daubner, Susan Colette / Astorga, Adrienne M. / Leisman, Gary / Baldwin, Thomas O.

Purification and characterization of an unusual nonfluores cent flavoprotein from Photobacterium leiognathi / O'Kane, D. J. / Vervoort, J. / Muller, F. / Lee, J.

Purification and some properties of FP390 from P. phosphoreum / Kasai, Sabu / Matsui, Kunio / Nakamura, Takao

STRUCTURE, MECHANISM, AND BIOSYNTHESIS OF FLAVOENZYMES CONTAINING COVALENTLY-BOUND FLAVINS

8α-Imidazolylflavins: Application of their redox and spectral properties to flavoenzyme systems / Edmondson, D. E. / De Francesco, R.

X-ray study of flavoenzymes containing covalently bound flavins / Mathews, F. S. / Lim, L. W.

Structural studies of P-cresol methylhydroxylase / Bellamy, H. D. / Mathews, F. S. / Mclntire, W. S. / Singer, T. P.

The chemical and stereochemical course of oxidation of 4- ethylphenol and other 4-alkylphenols by ^-cresol methylhydroxylase / Mclntire, William S. / Bohmont, Craig

Redox properties of trimethylamine dehydrogenase / Stankovich, M. T. / Steenkamp, D. J.

Redox properties of Escherichia coll fumarate reductase / Ackrell, Brian A. C. / Cochran, Bruce / Kearney, Edna B. / Cecchini, Gary

Reactions of lumiflavin with aminyl and a-amino radicals of piperazine / Surdhar, P. S. / Armstrong, D. A.

Kinetic probes of the proposed radical mechanism of monoamine oxidase / Walker, Mark C. / Edmondson, Dale E.

Stopped-flow studies on the mechanism of the oxidation of N-methyl - 4 - phenyl - 1 , 2 , 3 , 6 - tetrahydropyridine (HPTP) by monoamine oxidase / Ramsay, Rona R. / Koerber, Steven C. / Singer, Thomas P.

Methoxatin containing methylamine dehydrogenase: Enzyme reduction by primary amines / McWhirter, Robert B. / Klapper, Michael H.

Interaction of bacterial sarcosine oxidase with folate derivatives / Jörns, Marilyn Schuman / Kvalnes-Krick, Kalla

Sulfhydryl groups and the binding site of noncovalently bound FAD ofCorvnebacterlum sarcosine oxidase / Suzuki, Haruo / Kawamura-Konishi, Yasuko

Dimethylglycine dehydrogenase from pig liver mitochondria: Purification and properties / Ichihara, Chikako / Ohishi, Nobuko / Yagi, Kunio

Comparison of partial amino acid sequences deduced from the nucleotide sequence of a bovine adrenal monoamine oxidase cDNA clone to amino acid sequences obtained from bovine liver monoamine oxidase type B / Weyler, Walter / Powell, John / Hsu, Yun-Pung P. / Chen, Shiuan / Corey, David P. / Utterback, Margot / Titlow, Christian / Breakefield, Xandra O.

Covalent binding of FAD to Bacillus subtllis succinate dehydrogenase / Hederstedt, L.

6 - Hydroxy-D-nicotine oxidase: Expression of the flavoenzyme as a covalently flavinylated polypeptide / Brandsch, Roderich

The flavin-binding sites of 6-hydroxy-D- and 6-hydroxy-Lnicotine oxidase / Brandsch, Roderich / Hinkkanen, Ari E. / Mauch, Ludwig / Nagursky, Heiner / Decker, Karl

LIST OF PARTICIPANTS

AUTHOR INDEX

SUBJECT INDEX

Backmatter

Frontmatter

Preface

Organizing committee

Acknowledgements

Contents

STRUCTURE AND MECHANISMS OF FLAVOENZYMES

Absolute stereochemistry of flavins in enzyme - catalyzed reactions / Manstein, D. J. / Massey, V. / Pai, E. F.

Conserved cysteine pairs of mercuric ion reductase: an investigation of function via site-directed mutagenesis / Walsh, Christopher T. / Moore, Melissa J. / Distefano, Mark D.

Reduced forms of native mercuric reductase and their reactions with mercuric compounds - activity vs inhibition / Miller, S. M. / Massey, V. / Ballou, D. P. / Williams, C. H. / Moore, M. / Walsh, C. T.

Rapid-scan stopped-flow studies of the flavoenzyme mercuric reductase during catalytic turnover / Sandström, A. / Lindskog, S.

The penultimate cysteines in mercuric reductase aid in the reduction of mercury / Massey, V. / Miller, S. M. / Ballou, D. P. / Williams, C. H. / Moore, M. / Distefano, M. / Walsh, C. T.

The active center of glutathione reductase at 1.54 A resolution / Karplus, P. A. / Schulz, G. E.

Kinetic isotope effect studies on yeast, spinach and human erythrocyte glutathione reductases / Vanoni, M. A. / Wong, K. K. / Blanchard, J. S.

Excited electronic states of flavin-containing coenzyme models / Gückel, F. / Schweitzer, D. / Becker, K. / Schirmer, R. H. / Zipplies, M. F. / Staab, H. A.

Trypanothione reductase from Trypanosoma cruzi / Krauth-Siegel, R. L. / Schirmer, R. H. / Schöllhammer, T.

Inactivation of two-electron reduced Escherichia coll glutathione reductase by NADPH and NADH / Arscott, L. David / Drake, Donna M. / Williams, Charles H.

Studies on the active site of human erythrocyte glutathione reductase using 6-SCN-FAD and 6-mercapto - FAD / Massey, Vincent / Ghislat, Sandro / Ermler, Ulrich / Schulz, Georg E.

Protein engineering of glutathione reductase from Escherichia coli / Scrutton, N. S. / Berry, A. / Perham, R. N.

Studies on the active sites of lipoamide dehydrogenase and glutathione reductase / Sahlman, Lena / Williams, Charles H.

Cloning, organisation and nucleotide sequence of the Azotobacter vinelandii gene for lipoamide dehydrogenase / Kok, Arie de / Westphal, Adrie H.

Reaction of pig heart lipoamide dehydrogenase with monobromoacetone and 1,3-dibromoacetone / Lee, James S. / Williams, Charles H.

Site-directed mutagenesis of thioredoxin reductase / Prongay, Andrew J. / Engelke, David R. / Williams, Charles H.

Effects of urea on redox properties of streptococcal NADH peroxidase / Poole, Leslie B. / Claiborne, Al

Three dimensional structure of baker's yeast flavocytochrome b2 / Mathews, F. S. / Xia, Z. -x.

Mechanism of L-lactate dehydrogenation catalyzed by flavocytochrome b.2 from baker's yeast / Lederer, F. / Mathews, F. S.

Inactivation of yeast flavocytochrone b.2 with fluoropyruvate. Modification of the active site histidine / Urban, Philippe / Florence, Lederer

Evidence for an alteration of the flavin behavior induced by 2-methyl - 2,4 - pentandiol in cerevis iae flavocytochrome b2 / Tegoni, M. / Labeyrie, F.

Medium chain acyl-CoA dehydrogenase from pig kidney: Aspects of the reductive half - reaction / Thorpe, C.

Crystal structure of the general acyl-CoA dehydrogenase / Kim, J. J. P. / Wu, J.

Inactivation of general acyl-CoA dehydrogenase from pig k i dney by the suicide substrate methylenecyclopropylacetyl - CoA. Stucture of one of the covalent flavin-inhibitor adducts / Zeller, Hans-Dieter / Ghisla, Sandro

2 - Bromo-octanoyl CoA: Apseudo-substrateforgeneral acyl-CoA dehydrogenase / Hall, Carole L.

Reaction of pig kidney medium chain acyl-CoA dehydrogenase with ^ - oxidation intermediates / Powell, P. J. / Lau, S-M. / Thorpe, C.

Medium chain acyl-CoA dehydrogenase from pig kidney: I n activation of the reduced enzyme by 2-octynoy1-CoA / Zhou, Jing-Zhi / Thorpe, Colin

Oxidation - reduction of general acyl-CoA dehydrogenase by the butyryl-CoA / crotonyl-CoA couple. A new investigation of the rapid reaction kinetics / Schopfer, Lawrence M. / Massey, Vincent / Ghisla, Sandra / Thorpe, Colin

Catalytic versatility of butyryl-CoA dehydrogenase from M. elsdenii / Ellison, Patricia A. / Engel, Paul C.

Oxidation-reduction potential of glutaryl-CoA dehydrogenase from Paracoccus denitrifleans / Byron, Colleen M. / Stankovich, Marian T. / Husain, Mazhar

13C NMR studies on the complexes and reaction intermediates of D-amino acid oxidase / Miura, R. / Miyake, Y.

13C-,15N-, and 31P- NMR studies on 6-hydroxy-L-nicotine oxidase from Arthrobacter oxidans / Pust, Stefan / Vervoort, Jacques / Decker, Karl / Bacher, Adelbert / Müller, Franz

A study on the interaction between reduced D-amino acid oxidase and ligands / Nishina, Yasuzo / Ushijiaa, Hidetaka / Tojo, Hiroaasa / Shiga, Kiyoshi

D-Amino acid oxidase from the yeast Rhodotorula gracilis / Simonetta, M. Pilone / Casalin, P. / Pollegioni, L. / Vanoni, M. A. / Curti, B.

Purification and properties of D-aspartate oxidase from beef kidney / Negri, Armando / Williams, Charles H. / Massey, Vincent

Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating) / Koyama, H. / Suzuki, H. / Kawamura-Konishi, Y.

Time - resolved flavin fluorescence of pyridoxine-5-P oxidase from sheep brain / Visser, Antonie J.W. / Kwok, Francis / Churchich, Jorge E.

An active site thiol in lactate oxidase / Giegel, David A. / Williams, Charles H. / Massey, Vincent

Can methylenetetrahydrofolate reductase be used to evade the methyl trap? / Green, Jacalyn M. / Ballou, David P. / Matthews, Rowena G.

The catalytic mechanism of DNA photolyase / Jorns, Marilyn Schuman

FLAVOENZYME STRUCTURE AND ELECTRON TRANSFER MECHANISMS

Sequence and structure of Anacvstis nidulans flavodoxin: Comparisons with flavodoxins from other species / Laudenbach, David E. / Straus, Neil A. / Pattridge, Katherine A. / Ludwig, Martha L.

C-13, N-15, and two-dimensional NMR techniques in flavoprotein research / Miiller, Franz / Vervoort, Jacques / Mierlo, Carlo P.M. van / Mayhew, Steve G. / Berkel, Willem J.H. van / Bacher, Adelbert

Two dimensional NMR studies on Megasphaera elsdenii / Mierlo, Carlo van / Vervoort, Jacques / Miiller, Franz

Flavodoxin from Anabaena 7120: Uniform N-15 enrichment and nitrogen-15 and phosphorus - 31 NMR investigations of the FMN binding site in the reduced and oxidized states / Stockman, Brian J. / Markley, John L.

Pulse radiolysis studies on flavodoxin / Anderson, Robert F. / Massey, Vincent / Schopfer, Lawrence M.

Resonance raman investigations of flavins and flavoproteins / Lively, Chris R. / Gustafson, William G. / McFarland, James T.

Spectral studies on hydrogen bonded alloxazines / Kozioł, J. / Szafran, M. M. / Heelis, P. F.

Use of flavin and flavodoxin semiquinones as kinetic probes to elucidate the factors which determine reaction rate constants and biological specificity for electron transfer proteins / Tollin, Gordon / Cheddar, Glen / Hazzard, James T. / Meyer, Terrance E. / Cusanovich, Michael A.

Factors influencing the rate of electron transfer from flavodoxin to cytochrome c. / De Francesco, Raffaele / Tollin, Gordon / Brown, Kathleen / Edmondson, Dale E.

A computer graphics model of the complex formed between flavodoxin and the tetraheme cytochrome c.3 / Stewart, D. E. / LeGall, J. / Peck, H. D. / Wampler, J. E. / Moura, I. / Moura, J. J. G. / Xavier, A. V. / Weiner, P. K.

Cloning and nucleotide sequence of a bacterial flavodoxin gene: Towards the site-directed mutagenesis of the flavin binding site / Krey, Grigorios D. / Vanin, Elio F. / Swenson, Richard P.

Flavin binding site differences between Photobacterium phosphoreum lumazine protein and Megasphaera elsdenii flavodoxin. An investigation using circular dichroism and fluorescence / Visser, Antonie J. W. G. / Hoek, Arie van / Vervoort, Jacques / O'Kane, Dennis J. / Lee, John

Ferredoxin and ferredoxin-NADP+oxidoreductase interactions: Mapping of their binding sites / Zanetti, G. / Aliverti, A. / Curti, B. / Ronchi, S.

Complex formation between ferredoxin-NADP+-oxidoreductase and flavodoxin / Gomez-Moreno, C. / Sancho, J. / Fillat, M. / Pueyo, J. J. / Edmondson, D. E.

Notes:

Includes index.

Description based on online resource; title from PDF title page (publisher's Web site, viewed 15. Jun 2019)

ISBN:

9783110884715

3110884712

OCLC:

1105851472