Synthetic Biology and Its Consequences in Present Healthcare.

Format:

Book

Author/Creator:

Prajapati, Bhupendra G.

Language:

English

Subjects (All):

Synthetic biology.

Biotechnology.

Physical Description:

1 online resource (640 pages)

Edition:

1st ed.

Place of Publication:

Chantilly : Elsevier Science & Technology, 2025.

Summary:

Synthetic Biology enables the capability to manipulate and modify leaving cells and organisms to program them for specific purposes and has the potential to change the course of the healthcare sector.Synthetic Biology and its Consequences in Present Healthcare presents the latest findings and applications those in the healthcare sector need.

Contents:

Front Cover

Synthetic Biology and Its Consequences in Present Healthcare

Copyright Page

Dedication

Contents

List of contributors

About the editors

Preface

Acknowledgments

1 An introduction of synthetic biology and important milestones

1.1 Introduction

1.2 Methodology

1.2.1 Methodology for conducting the review paper

1.2.1.1 Comprehensive literature search

1.2.1.2 Data extraction and categorization

1.2.1.3 Thematic synthesis and analysis

1.2.1.4 Critical evaluation of research quality and gaps

1.2.1.5 Forecasting future directions

1.2.2 Methodology of synthetic biology research

1.2.2.1 Design and assembly of genetic constructs

1.2.2.2 DNA synthesis and cloning

1.2.2.3 Computational modeling and simulation

1.2.2.4 Characterization and testing

1.2.2.5 Iterative optimization

1.2.2.6 Ethical and safety evaluations

1.3 Foundational principles of synthetic biology

1.3.1 Genetic engineering

1.3.2 DNA synthesis and assembly

1.3.3 Computational modeling and bioinformatics

1.4 Major milestones in synthetic biology

1.4.1 Creation of synthetic genetic circuits

1.4.1.1 Concept and design

1.4.1.2 Applications of synthetic circuits

1.4.1.3 Advancements in circuit complexity

1.4.2 Synthesis of the first artificial cell

1.4.2.1 The J. Craig Venter Institute's synthetic cell

1.4.2.2 Significance and implications

1.4.2.3 Future potential of synthetic cells

1.4.3 Development and impact of CRISPR-Cas9 technology

1.4.3.1 Mechanism of CRISPR-Cas9

1.4.3.2 Applications in medicine and biotechnology

1.4.3.3 Ethical and regulatory considerations

1.5 Evolutionary trajectory of synthetic biology

1.5.1 Early discoveries and innovations

1.5.2 Integration with advanced technologies

1.5.3 Progress in methodologies and techniques.

1.6 Transformative impact of synthetic biology on science and industry

1.6.1 Impact on science

1.6.1.1 Advancing biomedical research and therapy

1.6.1.2 Expanding the frontiers of genomics and systems biology

1.6.2 Impact on industry

1.6.2.1 Revolutionizing the pharmaceutical industry

1.6.2.2 Transforming agriculture and food production

1.6.2.3 Enhancing environmental sustainability

1.6.2.4 Enabling new materials and manufacturing processes

1.7 Future directions and research avenues in synthetic biology

1.8 Conclusion

References

2 Applications of genome synthesis and editing in synthetic biology

2.1 Introduction

2.2 Principles of genome synthesis and editing

2.2.1 Genome synthesis

2.2.2 Genome editing

2.3 Genome synthesis in health care

2.3.1 Drug production

2.3.2 Synthetic vaccines

2.3.3 Attenuated vaccines

2.3.4 De novo genome design

2.3.4.1 Synthetic minimal genomes

2.3.4.2 Creation of synthetic viruses

2.3.5 Regenerative medicine

2.3.6 Diagnostic tools

2.4 Genome editing in health care

2.4.1 CRISPR/Cas9 in treating monogenic diseases

2.4.2 Immunotherapy

2.4.3 Editing microbial genomes

2.4.3.1 Engineering probiotics for therapeutic purposes

2.4.3.2 Editing microbiomes for disease management

2.4.4 Antimicrobial resistance

2.4.4.1 Phage engineering and genome editing

2.4.4.2 Development of synthetic antibiotics

2.5 Ethical, regulatory, and technical challenges

2.5.1 Ethical considerations

2.5.2 Regulatory frameworks

2.5.3 Technical challenges

2.6 Prospect and conclusion

Acknowledgment

3 Application of xenonucleotide in synthetic biology

3.1 Introduction

3.2 Properties of xenonucleic acids

3.2.1 Diverse chemical backbones

3.2.2 Exceptional stability

3.2.3 Functional versatility.

3.2.4 Orthogonality and biocontainment

3.2.5 Encoding genetic information

3.2.6 Applications in medicine and technology

3.2.7 Catalytic potential

3.2.8 Innovations in information systems

3.3 Enhanced stability of xenonucleic acids

3.3.1 Diverse chemical backbones

3.3.2 Chemical stability in harsh conditions

3.3.3 Functional versatility in synthetic biology

3.3.4 Prolonged functional activity

3.3.5 Synthetic genetic storage and transfer

3.3.6 Engineered safety and biocontainment

3.3.7 Catalytic innovation with XNAzymes

3.3.8 Pioneering therapeutic applications

3.3.9 Advancing artificial systems and data storage

3.4 Altered hybridization properties

3.4.1 Definition and background

3.4.2 Chemical modifications and impact on hybridization

3.4.3 Hybridization strength and specificity

3.4.4 Complementarity with natural nucleic acids

3.4.5 Resistance to structural perturbations

3.4.6 Applications leveraging altered hybridization properties

3.4.7 Comparison with natural hybridization

3.4.8 Engineering challenges and considerations

3.5 Resistance to degradation

3.5.1 Intrinsic chemical stability

3.5.2 Resistance to nuclease activity

3.5.3 Enhanced stability in biological environments

3.5.4 Chemical and environmental stability

3.5.5 Implications for biotechnology and medicine

3.5.6 Comparison with natural nucleic acids

3.6 Applications of xenonucleic acids in synthetic biology

3.6.1 Expanding the genetic alphabet

3.6.1.1 Designing novel genetic systems

3.6.1.2 Exclusive compatibility in synthetic systems

3.6.1.3 Improved biocontainment strategies

3.6.1.4 Advanced functional genomics

3.6.2 Genetic storage and data encoding

3.6.2.1 Durability for information preservation

3.6.2.2 Enhanced data security

3.6.2.3 High-density data encoding.

3.6.3 Gene regulation and control

3.6.3.1 Customizable regulatory molecules

3.6.3.2 Stability in synthetic networks

3.6.4 Biosensors and diagnostics

3.6.4.1 Resilience in diverse conditions

3.6.4.2 Precision in detection

3.6.5 Therapeutic applications

3.6.5.1 Precision in gene silencing

3.6.5.2 Tailored drug delivery systems

3.6.5.3 Supporting gene editing innovations

3.6.5.4 Advancing RNA-based therapeutics

3.6.5.5 Innovative vaccine platforms

3.6.5.6 Designing targeted therapies

3.7 Challenges and future directions

3.7.1 Synthesis and modification

3.7.1.1 Synthesis complexity

3.7.1.2 Structural challenges

3.7.1.3 Biological interaction

3.7.2 In vivo applications

3.7.2.1 Delivery challenges

3.7.2.2 Stability concerns

3.7.2.3 Therapeutic potential

3.7.2.4 Biocompatibility and safety

3.7.2.5 Synthetic and engineering limitations

3.7.2.6 Roadening applications

3.7.2.7 Regulatory and ethical considerations

3.7.3 Expanding the genetic code

3.7.3.1 Stability and functional integration

3.7.3.2 Application in synthetic biology

3.7.3.3 Potential for therapeutic use

3.7.4 Developing efficient synthesis methods

3.7.4.1 Efficient synthesis and modification

3.7.4.2 Enzymatic recognition and replication

3.7.4.3 Stability and biocompatibility

3.7.4.4 Biological applications

3.7.4.5 Structural and functional diversity

3.7.4.6 Ethical and safety considerations

3.7.5 Improving xenonucleic acid delivery systems

3.7.5.1 Improving xenonucleic acid delivery systems

3.7.5.2 Developing mechanisms for cellular uptake

3.7.5.3 Enhancing stability and integration

3.7.5.4 Scalability and synthesis challenges

3.7.6 Expanding xenonucleic acid−based genetic systems

3.7.6.1 Stability and functionality in living organisms.

3.7.6.2 Synthetic evolution and engineering

3.7.6.3 Challenges in scaling and practical applications

3.8 Future directions

3.9 Conclusion

4 Application of cell-free system in synthetic biology

4.1 Introduction

4.2 Fundamentals of cell-free systems

4.3 Advantages of cell-free systems in synthetic biology

4.4 Application of cell-free systems

4.4.1 Protein synthesis and engineering

4.4.2 Metabolic engineering and biosynthesis

4.4.3 Diagnostics and biosensors

4.4.4 Genetic circuit design and testing

4.5 Recent advances and emerging trends

4.6 Challenges and limitations

4.7 Future perspectives

4.8 Conclusion

5 Application of computational methods and artificial intelligence in synthetic biology

5.1 Introduction

5.2 Current scenario

5.2.1 Databases

5.2.2 Nucleic acids

5.2.2.1 Genome

5.2.2.2 Transcriptome

5.2.2.3 Epigenome

5.2.3 Proteins

5.2.4 Evolution

5.2.5 Artificial intelligence in synthetic biology

5.3 Principles/Methodology and applications

5.3.1 Modulate biomolecular interactions

5.3.2 Biomolecular simulations

5.3.3 Genome design

5.3.4 Knowledge incorporation and continuous integration

5.4 Future perspectives

5.4.1 Quantum computing

5.4.2 Programmable cells

5.4.3 Omics driven automated knowledge generation

5.4.4 Novel molecular design

5.5 Conclusion

6 Application of synthetic biology in bioactive peptide designing

6.1 Introduction

6.1.1 Importance of bioactive peptides and their sources

6.1.2 Current scenario

6.2 Summary of different steps involved in bioactive peptide design

6.2.1 Selection of protein for target bioactive peptide generation

6.2.2 Synthesis of bioactive peptide

6.2.3 Purification and identification of peptide sequence.

6.2.4 Postsynthesis stabilization.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

0-443-33650-4

OCLC:

1548750049