Toxicity : 77 Must-Know Predictions of Organic Compounds / Mohammad Hossein Keshavarz.

Format:

Book

Author/Creator:

Keshavarz, M. H. (Mohammad Hossein), author.

Series:

De Gruyter textbook.

De Gruyter Textbook Series

Language:

English

Subjects (All):

Toxicity testing.

Physical Description:

1 online resource (0 pages)

Edition:

First edition.

Place of Publication:

Berlin, Germany : Walter de Gruyter GmbH, [2023]

Summary:

Due to the advances of various methods for the prediction of toxicity of organic compounds and ionic liquids (ILs), it is necessary to review these methods for scientists and students. It is essential to compare the advantages and shortcomings of these methods. Since many organic compounds and ILs are synthesized each year, this book introduces suitable models for the assessment of their toxicities. This book reviews the best predictive methods for the prediction of toxicity of organic compounds and ILs, which were derived by in vitro or in vivo experiments. Different available quantitative structure‐toxicity relationship (QSTR) models based on various descriptors have been discussed to predict toxicity parameters such as LD50 (50% lethal dose), EC50 (the concentration of the desired IL that produces mortality of 50 percent of the bacterial population) and log(IGC50-1) (logarithm of 50% growth inhibitory concentration of T. pyriformis) of various classes of organic compounds and ILs. The reliability of these methods is compared and discussed. Each chapter contains some complimentary problems with their answers, which can improve the experience of students and researchers. The introduced subjects are suitable for advanced students in chemistry, biochemistry, medicinal chemistry, and chemical engineering.

Contents:

Intro

Preface

Contents

Chapter 1 Toxicity Assessment

Chapter 2 Toxicity of Small Data Sets of Organic Compounds

Chapter 3 Toxicity of Medium-Sized Data Sets

Chapter 4 Toxicity of Large Data Sets

Chapter 5 Toxicity of Ionic Liquids

List of Symbols

Answers to Problems

References

About the Author

Index.

Notes:

Description based on print version record.

Includes bibliographical references and index.

ISBN:

3-11-118967-8