Serine Proteases : Role in Human Health and Disease / Anil K. Sharma and Poonam Bansal.

Format:

Book

Author/Creator:

Sharma, Anil K., author.

Bansal, Poonam, author.

Language:

English

Subjects (All):

Serine proteinases.

Serpins.

Physical Description:

1 online resource (176 pages)

Edition:

First edition.

Place of Publication:

Berlin, Germany : Walter de Gruyter, [2023]

Summary:

Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

Contents:

Intro

About the editors

Preface

Acknowledgments

Contents

List of contributing authors

Chapter 1 Serine proteases: classification, catalytic mechanism, types, and industrial applications

Chapter 2 Serine proteases and respiratory disorders

Chapter 3 Role of serine proteases in cancer progression and metastasis

Chapter 4 Role of serine proteases in lung diseases: a view from acute and chronic lung infection complications

Chapter 5 Inhibition of the serine exopeptidase DPP-IV as a means of mitigation of diabetic nephropathy

Chapter 6 Serine proteases in arthritis

Chapter 7 Serine protease HtrA: a promising therapeutic target to develop antimicrobial therapy

Chapter 8 Potential targeted therapy for SARS-CoV-2: host serine proteases

Chapter 9 Role of serine proteases in fertility

Chapter 10 Serine protease inhibitors and its therapeutics

Index.

Notes:

Description based on print version record.

ISBN:

3-11-132504-0