Solubility in Pharmaceutical Chemistry / Christoph Saal, Anita Nair.

Format:

Book

Contributor:

Nair, Anita, Editor.

Saal, Christoph, Editor.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Physical Description:

1 online resource (viii, 362 pages) : illustrations

Place of Publication:

Berlin ; Boston : De Gruyter, [2020]

Language Note:

In English.

Summary:

This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

Contents:

Frontmatter

Contents

List of contributors

1. Solubility - definition and basic physicochemical considerations

2. Solubility and supersaturation

3. In Silico methods to predict solubility

4. How solubility influences bioavailability

5. Estimation of intraluminal drug solubility

6. Biorelevant media

7. The role of solubility to optimize drug substances - a medicinal chemistry perspective

8. The role of solubility in optimizing drug products - a pharmaceutical development perspective

9. The relevance of solid-state forms for solubility

10. Solubility and phase behaviour from a drug substance manufacturing perspective

11. Biowaivers

List of Abbreviations

Index

Notes:

Includes index.

Description based on online resource; title from PDF title page (publisher's Web site, viewed 06. Apr 2020)

ISBN:

9783110559835

3110559838

9783110558883

3110558882

OCLC:

1135589155