Chemistry of nucleic acids / Harri Lönnberg.

Format:

Book

Author/Creator:

Lönnberg, Harri, author.

Series:

De Gruyter Textbook

Language:

English

Subjects (All):

Nucleic acids.

Physical Description:

1 online resource (XI, 353 p.)

Place of Publication:

Berlin ; Boston : De Gruyter, [2020]

Language Note:

In English.

Summary:

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Contents:

Frontmatter

Preface

Contents

1 Nucleosides: structure, nomenclature and solution equilibria

2 Nucleosides: synthesis, reactions and use in chemotherapy

3 Nucleotides

4 Oligonucleotides: synthesis

5 Oligonucleotides: reactions of phosphodiester linkages

6 Oligonucleotide conjugates

7 Nucleic acids

8 Catalytic nucleic acids

9 Nucleic acids as drugs and drug targets 1: antisense, splice-switching, triplex-forming and immune-stimulatory oligonucleotides

10 Nucleic acids as drugs and drug targets 2: RNA interference, 2′,5′-oligoadenylates and riboswitches

11 Nucleic acids as drugs and drug targets 3: target recognition and delivery

Abbreviations

Index

Notes:

Description based on print version record.

ISBN:

3-11-060929-0

OCLC:

1191864281