Immunological Challenges in Organ Transplantation : A Comprehensive Case-Based Approach / edited by Georgi Abraham, Vivek Kute, Narayan Prasad, Dolly Daniel, Shruti Tapiawala.

Format:

Book

Author/Creator:

Abraham, Georgi.

Contributor:

Kute, Vivek.

Prasad, Narayan.

Daniel, Dolly.

Tapiawala, Shruti.

Series:

Medicine Series

Language:

English

Subjects (All):

Nephrology.

Immunology.

Biology--Technique.

Biology.

Experimental immunology.

Translational Immunology.

Immunological Techniques.

Local Subjects:

Nephrology.

Translational Immunology.

Immunological Techniques.

Physical Description:

1 online resource (441 pages)

Edition:

1st ed. 2025.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2025.

Summary:

Transplantation in South Asia faces unique immunological challenges, yet comprehensive data on genetic and epigenetic factors in the region remains sparse. This ground-breaking book addresses the critical need for a uniform approach to the immunological workup of transplant recipients and donors, tailored specifically for one of the world’s highest-volume transplantation regions. Drawing on insights from renowned immunologists, transplant physicians, and surgeons, the book provides an in-depth exploration of immune signatures in South Asian populations. It offers actionable guidance to optimize donor-recipient matching and minimize immune system activation during and after transplantation. Through a practical, case-based approach, the book delves into real-world immunological challenges and solutions, covering key topics such as immunosuppressive strategies for children, adults, older patients, and women with prior sensitization. Each chapter is designed to equip healthcare professionals with the tools to address complex scenarios with confidence. With over 650 transplantation centers in India alone, this essential resource is invaluable for trainees, nurses, technicians, and all members of the transplant team seeking to enhance their understanding of immunology in transplantation.

Contents:

Chapter1.. HLA Structure, Function, and Clinical Implications in Transplantation: A Case-Based and Molecular Perspective

Chapter2.. Nutrition and immunological challenges in transplantation

Chapter3.. Why we require immunological workup- A patient-centered, case-based approach

Chapter4.. HLA loci and typing in solid organ transplantation - A case-based approach to HLA typing and applications in clinical practice

Chapter5.. Eplets and Epitopes in transplantation

Chapter6.. Virtual cross match in kidney transplantation

Chapter7.. Molecular Biomarkers to Assess Kidney Allograft Status

Chapter8.. Approach to an unsensitised patient awaiting first renal transplant – Algorithms of choice

Chapter9.. A case based approach to the sensitised recipient with DSA on the SAB to the proposed donor

Chapter10.. Non-HLA Antibodies in Kidney Transplantation

Chapter11.. A persistent CDC positive cross-match in a patient awaiting transplant - Variations of the CDC and comparisons across platforms

Chapter12.. Kidney Transplant Rejection: T-Cell and Antibody-Mediated Rejection

Chapter13.. Immunology of ABO incompatible transplantation

Chapter14.. Approach to Lung transplant immunology

Chapter15.. Immunology of heart transplantation

Chapter16.. Approach to Liver Transplant: The Immunomodulatory Role of the Liver and Its Mesenchymal Stem Cells

Chapter17.. Challenges in Bone Marrow Transplant: Tale of Two Women

Chapter18.. Immunological Evaluation and Management of pediatric kidney transplant recipients

Chapter19.. An approach to rational therapeutics by navigating pathophysiology and evidence for complex clinical situations

Chapter20.. Immunological challenges in Xenotrasplantation

Chapter21.. Conclusions, Recommendations and guidelines for immunological evaluation of a transplant recipient.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

981-9515-33-5

9789819515332

OCLC:

1572220020