Epigenetics and Rare Diseases / edited by Lorenzo Emmi, Vassilios Fanos.

Format:

Book

Author/Creator:

Emmi, Lorenzo.

Contributor:

Fanos, Vassilios.

Series:

Rare Diseases of the Immune System, 2283-6403

Language:

English

Subjects (All):

Immunology.

Rheumatology.

Genetics.

Oncology.

Genetics and Genomics.

Local Subjects:

Immunology.

Rheumatology.

Genetics and Genomics.

Oncology.

Physical Description:

1 online resource (388 pages)

Edition:

1st ed. 2025.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2025.

Summary:

Epigenetics, as well as all -omics fields of study, such as transcriptomics, proteomics and metabolomics, have caused a revolution in all branches of medicine in recent years. This book provides a detailed evidence-based overview of the latest developments in how the recent acquisitions on the human genome and epigenome is relevant, and how it impacts our understanding of rare diseases of the immune system. The first part features the evolving thread from genetics to epigenetics, their molecular basis, endocrine disruptors, as well as chapters devoted to the fetal programming hypothesis and functional basis of neurodevelopment, and the placenta as originating element. Successive chapters include contributions on the impact of epigenetics on cancer, as well as a comprehensive array of disorders as autoimmune disorders, allergic and metabolic diseases, systemic vasculitis, aging and inflammatory diseases, neurological and psychiatric conditions. The overview closes with considerations on the “-Omics” revolution and precision medicine, and the reflection of epigenetics on the microbiome. By providing guidance on how the latest information can be applied by the medical practitioner in day-to-day clinical practice, and collating the latest developments in rare diseases treatments to the “omics” that are relevant for the clinician while advocating for a patient-centered approach, Epigenetics and Rare Diseases will be a valued resource for clinicians, healthcare professionals, and patient associations.

Contents:

Preface

1. From Genetics to Epigenetics: The Steps of a Path

2. Molecular basis of epigenetic mechanisms

3. Epigenetics and Endocrine Disruptors

4. New insights into the fetal programming hypothesis of the linkage between neurodevelopmental disorders and impaired neurogenesis

5. The Placenta and the development of human health

6. Epigenetics and cancer

7. Epigenetics in Autoimmune Diseases

8. Epigenetics and Systemic Vasculitis

9. Epigenetics and Allergic Diseases

10. The Role of Epigenetics in Autoinflammatory Diseases

11. Epigenetics and immune-mediated diseases

12. Epigenetics and Inherited Metabolic Disorders

13. Epigenetics and Psychiatric Diseases

14. The metabolomics revolution toward personalized medicine: the case of gestational diabetes

15. Epigenetics and Microbiome

Index.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

3-032-02902-3

9783032029027

OCLC:

1545597321