NTP technical report on the toxicology and carcinogenesis studies of p-Chloro-α,α,α-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley (Hsd: Sprague Dawley(r) sD(r)) rats and B6C3F1/N mice (Inhalation studies) / National Toxicology Program (U.S.).

Format:

Book

Author/Creator:

National Toxicology Program (U.S.), author, issuing body.

Language:

English

Subjects (All):

Toxicology--Animal models.

Toxicology.

Carcinogenesis--Animal models.

Carcinogenesis.

Physical Description:

1 online resource : illustrations

Place of Publication:

Research Triangle Park, North Carolina, USA : National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services, 2018.

Summary:

p-Chloro-α,α,α-trifluorotoluene is a solvent used in paints and coatings and as an industrial intermediate in the production of other chemicals (e.g., herbicides, dyes, pharmaceuticals). p-Chloro-α,α,α-trifluorotoluene was nominated for study by the National Cancer Institute and Kowa American Corporation for study because of its high import volume and lack of occupational exposure limits. Male and female Hsd:Sprague Dawley SD rats and B6C3F1/N mice were exposed to p-chloro-α,α,α-trifluorotoluene (purity greater than 99.5%) by inhalation for 3 months or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichia coli, and rat and mouse peripheral blood erythrocytes.

Notes:

Description based on publisher supplied metadata and other sources.