Motor neurone disease : the use of non-invasive ventilation in the management of motor neurone disease / National Institute for Health and Clinical Excellence.

Format:

Book

Series:

National clinical practice guideline ; Number 105.

National clinical practice guideline ; Number 105

Language:

English

Subjects (All):

Motor neurons--Diseases.

Physical Description:

1 online resource.

Place of Publication:

London : National Institute for Health and Clinical Excellence, 2010.

Summary:

Motor neurone disease (MND) is a fatal neurodegenerative disease. It is characterised by the onset of symptoms and signs of degeneration of primarily the upper and lower motor neurones. This leads to progressive weakness of the bulbar, limb, thoracic and abdominal muscles. Respiratory muscle weakness resulting in respiratory impairment is a major feature of MND, and is a strong predictor of quality of life and survival. Non-invasive ventilation can improve symptoms and signs related to respiratory impairment and hence survival. There is currently no evidence-based guideline for use in England, Wales and Northern Ireland that addresses the use of non-invasive ventilation in patients with MND. This guideline considers the signs and symptoms that can be used for predicting respiratory impairment in patients with MND, the diagnostic accuracy of investigations for detecting and monitoring respiratory impairment, the clinical and cost effectiveness of non-invasive ventilation for treating respiratory impairment and the information and support needs of patients and their families and carers relating to the use of non-invasive ventilation.

Contents:

Introduction

Patient-centred care

1. Summary

1.1. List of all recommendations

1.2. Care pathways

1.3. Overview

2. How this guideline was developed

2.1. The identification and assessment of respiratory impairment in patients with motor neurone disease: clinical symptoms and signs

2.2. The identification and assessment of respiratory impairment in patients with motor neurone disease: respiratory function tests

2.3. Clinical and cost effectiveness of non-invasive ventilation for the treatment of respiratory impairment in patients with motor neurone disease

2.4. Key elements in the management of the use of non-invasive ventilation for patients with motor neurone disease

2.5. Information and support needs of patients with motor neurone disease and their families and carers

3. Research recommendations

3.1. Cost effectiveness of non-invasive ventilation for patients with MND

3.2. Withdrawing non-invasive ventilation at the end of life

3.3. Communication with patients, families and carers

3.4. Non-invasive ventilation for patients with MND with severe bulbar impairment

3.5. Training and education needs

4. Other versions of this guideline

Quick reference guide

'Understanding NICE guidance'

5. Related NICE guidance

Published

6. Updating the guideline

7. References, glossary and abbreviations

7.1 References

7.2 Glossary

7.3 Abbreviations

8. Contributors

8.1. The Guideline Development Group

8.2. The short clinical guidelines technical team

8.3. The short clinical guidelines team

8.4. Centre for Clinical Practice

8.5. The Guideline Review Panel

8.6. Declarations of interest

8.7. Authorship and citation

9 Appendices

Appendix 9.1. Scope

Appendix 9.2. Key clinical issues, review questions and review protocol

Appendix 9.3. Results of GDG short questionnaires

Appendix 9.4. Lists of excluded studies

Appendix 9.5. Literature search and search strategies

Appendix 9.6. Evidence tables

Appendix 9.7. Health economic evaluation.

Notes:

Description based on publisher supplied metadata and other sources.