Drug class review : Newer antiemetics : final report update 1 / Kimberly Peterson [and three others].

Format:

Book

Author/Creator:

Peterson, Kimberly, author.

Language:

English

Subjects (All):

Antiemetics.

Physical Description:

1 online resource

Place of Publication:

Portland, OR : Oregon Health & Science University, 2008.

Summary:

Nausea and vomiting are major concerns for patients undergoing chemotherapy, radiation therapy and surgery with general anesthesia. Risk factors associated with chemotherapy-induced nausea and vomiting include emetogenicity of the chemotherapy regimen, dose, speed of intravenous infusion, female gender, age under 50 years, history of ethanol consumption, and history of prior chemotherapy. Factors predictive of radiation therapy-induced nausea and vomiting include site of irradiation (in particular, total body irradiation and radiation fields that include the abdomen), total field size, dose per fraction, age, and predisposition for emesis (history of sickness during pregnancy or motion sickness). Female gender, a history of motion sickness or prior postoperative nausea and vomiting, nonsmoking status, and use of postoperative opioids have been suggested as factors predictive of postoperative nausea and vomiting. The objective of this review was to evaluate the comparative effectiveness and harms of newer antiemetic drugs including the 5-HT3 and NK-1 antagonists.

Contents:

Introduction

Purpose and Limitations of Systematic Reviews

Scope and Key Questions

Inclusion Criteria

Methods

Literature Search

Study Selection

Data Abstraction

Validity Assessment

Data Synthesis

Peer Review and Public Comment

Results

Overview

Summary of Findings

Detailed Assessment

Summary

References

Appendix A. US Food and Drug Administration recommendations for adult dosages

Appendix B. US Food and Drug Administration recommendations for pediatric dosages

Appendix C. Glossary

Appendix D. Search strategy

Appendix E. Methods used to assess quality of studies

Appendix F. Excluded studies

Evidence Tables.

Notes:

Description based on publisher supplied metadata and other sources.