Drug class review on cyclo-oxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) : final report update 3 / Roger Chou and Mark Helfand.

Format:

Book

Author/Creator:

Chou, Roger, author.

Helfand, Mark, author.

Language:

English

Subjects (All):

Anti-inflammatory agents.

Outcome assessment (Medical care).

Physical Description:

1 online resource (43 pages)

Place of Publication:

Portland, Oregon : Oregon Health & Science University, 2006.

Summary:

Non-steroidal anti-inflammatory drugs (NSAIDs) reduce pain and inflammation by blocking cyclo-oxygenases (COX), enzymes that are needed to produce prostaglandins. Most NSAIDs block two different cyclo-oxygenases, called COX-1 and COX-2. COX-2, found in joint and muscle tissue, contributes to pain and inflammation. Many NSAIDs also block COX-1, which may contribute to development of ulcers and gastrointestinal bleeding depending on the magnitude of blockade. More recently, some NSAIDs have also been associated with an increased risk of serious cardiovascular events, such as myocardial infarction. The purpose of this review is to compare the efficacy, effectiveness, and harms of NSAIDs.

Contents:

Introduction

Scope and Key Questions

Methods

Literature Search

Study Selection

Data Abstraction

Validity Assessment

Results

Overview

Key Question 1. Are there differences in effectiveness between coxibs and other NSAIDs?

Key Questions 2 and 3. Are there clinically important differences in short-term safety or adverse effects between celecoxib, other NSAIDS, or the combination of a nonselective NSAID plus antiulcer medication? Are there clinically important differences in long-term safety or adverse effects between celecoxib, other NSAIDS, or the combination of a nonselective NSAID plus antiulcer medication?

Key Question 4. Are there subgroups of patients based on demographics, other medications (e.g., aspirin), or co-morbidities for which one medication is more effective or associated with fewer adverse effects?

Summary

References

Appendixes

Appendix A. NSAIDs selectivity

Appendix B. Search Strategy

Appendix C. Quality assessment methods for drug class reviews for the Drug Effectiveness Review Project

Appendix D. Excluded trials.

Notes:

Description based on publisher supplied metadata and other sources.