Therapies for treatment-resistant depression : neuropharmacology and neurostimulation / edited by James W. Murrough, Dennis S. Charney.

Format:

Book

Contributor:

Murrough, James W., editor.

Charney, Dennis S., editor.

Language:

English

Subjects (All):

Depression, Mental--Treatment.

Depression, Mental.

Neuropharmacology.

Electrotherapeutics.

Depressive Disorder, Treatment-Resistant--therapy.

Electric Stimulation Therapy.

Medical Subjects:

Neuropharmacology.

Depressive Disorder, Treatment-Resistant--therapy.

Electric Stimulation Therapy.

Physical Description:

1 online resource (xxvi, 376 pages) : illustrations (chiefly color)

Place of Publication:

London, U.K. ; Cambridge, MA : Academic Press, [2025]

System Details:

data file

Summary:

Provides readers with an authoritative, comprehensive and targeted treatment guide. The first section reviews the essential knowledge and methods of clinical neuroscience and neuropsychopharmacological techniques as they apply to novel treatment discovery for depression. This is followed by detailed chapters on ketamine, esketamine, other glutamate modulators in development, GABA modulators, neuropeptides, anti-inflammatory agents, and other classes of novel therapeutics under study for TRD and related mood disorders. The last section consists of a set of chapters of special interest that includes current and future research directions, development of psilocybin-based interventions and other psychedelic compounds currently under study for TRD and advances in biomarker-guided and personalized treatment. Edited by world renowned experts in the field, this book is the ultimate resource for researchers and clinicians.

Contents:

Treatment-resistant depression: epidemiology and clinical presentation

Molecular neuropharmacology of treatment-resistant depression

Neurobiology and neuroimaging of treatment resistant depression

Pharmacotherapy of treatment-resistant depression: overview and look ahead

Lithium, dopamine modulators, and other augmentation strategies for treatment-resistant depression

Ketamine and esketamine for treatment-resistant depression

Impact of inflammation on treatment resistance in depression: mechanisms and translational opportunities

Novel pharmacotherapies for treatment-resistant depression: a focus on glutamate and gamma-aminobutyric acid modulators

Electroconvulsive therapy for treatment-resistant depression

Transcranial magnetic stimulation for treatment-resistant depression

Vagal nerve stimulation for treatment-resistant depression

Deep brain stimulation for treatment-resistant depression

Psilocybin and other psychedelic agents in development for treatment-resistant depression

Neuroimaging biomarkers in treatment selection for treatment-resistant depression

The role of genetics in treatment-resistant depression.

Notes:

Includes bibliographical references.

Online resource; title from table of contents page (Elsevier ClinicalKey, viewed October 6, 2025).

Other Format:

Print version:

Print version: Therapies for treatment-resistant depression.

ISBN:

9780443160066

0443160066

OCLC:

1531468850

Access Restriction:

Restricted for use by site license.