Drug class review on HMG-CoA reductase inhibitors (statins) : final report / Mark Helfand, Susan Carson and Cathy Kelley.

Format:

Book

Author/Creator:

Helfand, Mark, author.

Carson, Susan, author.

Kelley, Cathy, author.

Language:

English

Subjects (All):

Statins (Cardiovascular agents).

Physical Description:

1 online resource (75 pages)

Place of Publication:

Portland, Oregon : Oregon Health & Science University, Evidence-Based Practice Center, 2006.

Summary:

In the United States, coronary heart disease (CHD) and cardiovascular disease (CVD) account for nearly 40% of all deaths each year. High levels of cholesterol, or hypercholesterolemia, are an important risk factor for CHD. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum low-density lipoprotein cholesterol (LDL-c) concentrations. The purpose of this review is to compare the efficacy and adverse effects of different statins.

Contents:

Introduction

Scope and Key Questions

Methods

Literature Search

Eligibility Criteria and Study Selection

Data Abstraction

Validity Assessment

Data Synthesis

Results

Key Question 1. How do statins compare in their ability to reduce LDL-c?

Key Question 2. How do statins compare in their ability to increase HDL-c?

Key Question 3. How do statins compare in their ability to reduce the risk of nonfatal myocardial infarction, angina, CHD mortality, all-cause mortality, stroke or need for revascularization (coronary artery bypass graft, angioplasty or stenting)?

Revascularization Studies with Restenosis or Clinical Outcome Endpoints

Key Question 4. Are there differences in the efficacy or safety of statins in different demographic groups (age, sex, race)?

Key Question 5. Are there differences in the safety of statins?

Summary of Evidence

References

Appendixes

Appendix A. Search strategy

Appendix B. Quality assessment methods for drug class reviews for the Drug Effectiveness Review Project

Appendix C. Excluded trials

Evidence Tables.

Notes:

Description based on publisher supplied metadata and other sources.