Nanotechnology in Drug Discovery / Laksiri Weerasinghe, Imalka Munaweera, and Senuri Kumarage.

Format:

Book

Author/Creator:

Weerasinghe, Laksiri, author.

Munaweera, Imalka, author.

Kumarage, Senuri, author.

Language:

English

Subjects (All):

Nanotechnology.

Drug development.

Physical Description:

1 online resource (222 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., 2024.

Summary:

This book provides a compressive overview of nanotechnology in modern drug discovery for students and researchers. The book starts with the fundamentals of nanotechnology followed by nanomaterials in pharmaceutical drug design, drug delivery applications, regulatory aspects, formulation and nanoparticle biotransformation. It provides a step by step guide through the drug development process while conveying information about the benefits of nanomaterials for therapy. The book concludes with perspective on the future of nanotechnology-based drug discovery, summarizing current knowledge on nanotherapeutics and translational medicine. Key Features - Explains the fundamentals of nanotechnology in drug discovery - Includes up-to-date information on modern nanopharmaceutical manufacturing, nanomaterials, and nanoparticle-based drug therapy - Practice questions for learners and a list of references for advanced readers for each chapter Readership Students and researchers in pharmacology and pharmaceutical manufacturing programs.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

Fundamentals of Nanotechnology

1. INTRODUCTION TO NANOMATERIALS

1.1. Changes in Thermal Properties

1.2. Changes in Optical Properties

1.3. Changes in Electronic Properties

1.4. Changes in Electrical Properties

1.5. Changes in Magnetic Properties

1.6. Changes in Chemical Properties

2. SYNTHESIS AND CHARACTERIZATION METHODS OF NANOMATERIALS

2.1. Bottom-up Synthesis Methods

2.1.1. Chemical Vapour Deposition

2.1.2. Physical Vapour Deposition

2.1.3. Thermal Decomposition

2.1.4. Chemical Reduction

2.1.5. Photo-reduction

2.1.6. Biological Synthesis

2.1.7. Solvothermal

2.1.8. Sol-gel

2.1.9. Co-precipitation

2.2. Top-down Synthesis Methods

2.2.1. Mechanical Ball Milling

2.2.2. Nanolithography

2.2.3. Laser Ablation

2.2.4. Electrospinning

2.3. Characterisation of Nanomaterials

3. NANODEVICES

3.1. Atomic Force Microscopy

3.2. Nanoarrays/nanochips

3.3. Nanofluidics

3.4. Nano Biosensors

3.5. Nanobiopsy

4. ADVANTAGES OF EMPLOYING NANOMATERIALS AND NANODEVICES IN DRUG DISCOVERY

5. CHALLENGES AND OPPORTUNITIES IN NANOSCALE

5.1. Challenges

5.2. Opportunities

CONCLUSION

PRACTICE QUESTIONS

REFERENCES

Nanotechnology in Drug Development

Development of Nanomaterials as Drug Candidates

1. INTRODUCTION

2. DENDRIMERS

3. CARBON BASED NANOPARTICLES

3.1. Carbon Nanotubes

3.2. Fullerenes

3.3. Graphene Oxide and Derivatives

3.4. Carbon Quantum Dots

4. NANOHYDROGEL

5. PEPTIDE NANOSTRUCTURES

6. MXENES

7. SILICENE

8. ANTIMONENE

Nanotechnology for Drug Design and Drug Delivery

2. ATTRIBUTES OF AN EFFECTIVE DELIVERY SYSTEM

3. UP-TO-DATE DRUG DELIVERY SYSTEMS.

3.1. Liposomes

3.2. Polymeric Micelles

3.3. Nanogels

3.4. Nanoemulsions

3.5. Solid Lipid Nanoparticles

3.6. Dendrimers

3.7. Inorganic Nanoparticles

3.8. Electrospun Polymeric Nanofiber

Fate of Nanoparticles

2. CELL UPTAKE AND METABOLISM

2.1. Endocytosis

2.1.1. Clathrin-mediated Endocytosis

2.1.2. Caveolin-dependent Endocytosis

2.1.3. Clathrin and Caveolin-independent Endocytosis

2.1.4. Phagocytosis

2.1.5. Macropinocytosis

2.2. Direct Fusion with the Plasma Membrane

2.2.1. Cytoplasmic Entry by Direct Translocation

2.2.2. Cytoplasmic Entry by Lipid Fusion

2.2.3. Electroporation

Regulation, Development, and Commercialization of Nano-Based Drugs

Future of Nanotechnology-Based Drug Discovery

2. FUTURE OF NANOTECHNOLOGY IN DISEASE DIAGNOSIS AND THERAPY

3. PATIENT FOLLOW-UP AFTER TREATMENTS

4. NANOTECHNOLOGY IN OVERCOMING CANCER DRUG RESISTANCE

5. TRANSLATION OF NANOMEDICINE INTO SOLID DOSAGES

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9789815238815

9815238817

OCLC:

1449501874