Biotechnology and drug development for targeting human diseases / Israel Valencia Quiroz.

Format:

Book

Author/Creator:

Quiroz, Israel Valencia, author.

Series:

Recent Advances in Biotechnology Series

Language:

English

Subjects (All):

Biotechnology.

Physical Description:

1 online resource (235 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2024]

Summary:

Biotechnology and Drug Development for Targeting Human Diseases is an insightful compendium on drug development technologies for professionals and students in biotechnology and pharmacology. This book meticulously explores the intersection of biotechnology with drug development, emphasizing its crucial role in creating new therapies for human disease. Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound healing, and the use of viruses as carriers in biotechnology. Key features of this reference include a blend of theoretical knowledge and practical insights, detailed analyses of molecular docking in drug discovery, the repurposing of drugs for various diseases, and the emerging field of omics technologies in drug interaction studies. Each chapter is comprehensive, offering current information backed by extensive references, making the book both a foundational and advanced resource. Readership Students and professionals in the fields of biotechnology and pharmacology.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Multi-omics Profiles are Applicable to Human Diseases and Drug Development

Adriana Montserrat Espinosa-González1, José del Carmen Benítez-Flores2, Juan Carlos Gómez-Verjan3, Nadia Alejandra Rivero-Segura3, Ignacio Peñalosa Castro1, Jose Cruz Rivera Cabrera4 and Edgar Antonio Estrella-Parra1,*

INTRODUCTION

ANCESTRAL KNOWLEDGE: TRADITIONAL MEDICINE IN THE MULTIOMICS ERA

GLOBALIZATION OF TRADITIONAL MEDICINE

THE CONSTRUCTION OF NEW DRUGS BASED ON THE OMICS APPROACH

OMICS SCIENCE IN PERSONALIZED MEDICINE: A GOLD STANDARD

CHALLENGES IN THE DISCOVERY OF NEW DRUGS

BIOINFORMATICS IN OMICS: AN ACCUMULATION OF EXPERIENCES IN SYNERGY

CONCLUSION

REFERENCES

Utilizing in silico Methods in New Drug Design

Olivia Pérez-Valera1, Yuri Córdoba-Campo2, Rafael Torres-Martínez3, Yesica R. Cruz-Martínez1,4 and Israel Valencia Quiroz5,*

Review of the Different Docking Algorithms, Including their Strengths and Limitations

INFECTIOUS DISEASES (TUBERCULOSIS)

Case Study: Bedaquiline

Clinical Trials and Approval

Real-World Impact on Disease Treatment

CANCER (RENAL CELL CARCINOMA AND HEPATOCELLULAR CARCINOMA)

Disease Characteristics

Molecular Targets and their Role in Disease

CARDIOVASCULAR DISEASES (VENOUS THROMBOEMBOLISM AND STROKE)

Molecular Target and their Role in the Disease

AUTOIMMUNE DISEASES (RHEUMATOID ARTHRITIS)

METABOLIC DISORDERS (TYPE 2 DIABETES)

PSYCHIATRIC DISORDERS (DEPRESSION)

Molecular Targets and their Role in the Disease

Molecular Docking Approach

Case Study: Vortioxetine

Drug Development Process using Molecular Docking

Clinical Trials and Approval.

Real-World Impact on Disease Treatment

GENETIC DISORDERS (CYSTIC FIBROSIS)

Case Study: Lumacaftor

BONE-RELATED DISEASES (OSTEOPOROSIS)

Case Study: Odanacatib

EYE DISORDERS (GLAUCOMA)

Disease Overview

Case Study: Brimonidine

Real-world Impact on Disease Treatment

CHALLENGES AND LIMITATIONS IN THE USE OF MOLECULAR DOCKING FOR DRUG DEVELOPMENT AND STRATEGIES TO OVERCOME THEM

The Roles of Farnesol and Farnesene in Curtailing Antibiotic Resistance

Axel R. Molina-Gallardo1, Yesica R. Cruz-Martínez1, Julieta Orozco-Martínez1, Israel Valencia Quiroz2 and C. Tzasna Hernández-Delgado1,*

MATERIALS AND METHODS

RESULTS

Antibacterial Activity in Qualitative Terms

Antibacterial Activity in Quantitative Terms

Antibiofilm Effects of Farnesol and Farnesene

The Sensitizing Effect of Farnesol and Farnesene

Bacterial Growth Curves: A Deep Dive

Molecular Docking: A Glimpse into the Molecular World

DISCUSSION

The Role of Farnesene

Farnesol's Antibacterial Potential

Mechanisms of Resistance and Sensitization

Synergistic Effects of Antibiotics

Molecular Insights

Application of Viruses as Carriers in Biotechnology

Viridiana R. Escartín-Alpizar1,*, Julieta Orozco-Martínez1 and Israel Valencia Quiroz2

GENERAL ADVANTAGES OF VIRUS-BASED DELIVERY SYSTEMS

ADVANTAGES OF USING VIRAL VECTORS IN VACCINE DEVELOPMENT

Viruses to Develop Vaccines for COVID-19

Viruses to Develop Influenza Vaccines

Viruses to Develop Vaccines for HIV.

Viruses to Develop Vaccines for Malaria

Ability of Virus to Stimulate a Humoral Response

Ability of Virus to Stimulate a Cellular Immune Response

Anticancer Drug Delivery using Viral Vectors

Development of Personalized Vaccines for Cancer Immunotherapy

STRATEGIES USED TO TARGET SPECIFIC CANCER CELLS

ONCOLYTIC VIRUSES

RISKS AND POTENTIAL COMPLICATIONS OF VIRUS-BASED DELIVERY SYSTEMS

Regulatory Issues during Development and Testing of Viral Vectors for Clinical Use

ACKNOWLEDGEMENT

Phenolic Compounds with Photo-Chemoprotective Activity

Erick Nolasco-Ontiveros1,*, María del Socorro Sánchez-Correa2, José Guillermo Avila-Acevedo1, Rocío Serrano-Parrales3 and Adriana Montserrat Espinosa-González1

PHOTOCHEMOPROTECTION

PHENOLIC COMPOUNDS

Phenolic Acids

Caffeic Acid

Ferulic Acid

Gallic Acid

Phenylpropanoids

Rosmarinic Acid

Stilbenes

Resveratrol

Piceatannol

Pterostilbene

Flavonoids

Flavonols

Catechin and Epicatechin

Flavones

Apigenin

Luteolin

Quercetin and Rutin

Kaempferol

Curcumin

Isoflavonoids

Genistein

Equol

Anthocyanins

Tannins

Ellagic Acid

Tannic Acid

Lignins

LIST OF ABBREVIATIONS

Natural Products in Wound Regeneration

Nallely Álvarez-Santos1,2, Rocío Serrano-Parrales3, Patricia Guevara-Fefer4, Felix Krengel4 and Ana María García-Bores1,*

NATURAL PRODUCTS: EXTRACTS AND SECONDARY METABOLITES

BIOTECHNOLOGY IN WOUND REGENERATION

Hydrogels

Nanotechnology

Nanoparticles

Nanofibrous

Nanoemulsion

Antimicrobial Effect of Natural Products against Bacteria, Fungi, and Yeasts

Mai M. Badr1,* and Israel Valencia Quiroz2

INTRODUCTION.

EXPLORING THE ORIGINS AND DIVERSITY OF NATURAL ANTIBIOTICS

Botanical Origins: Natural Antimicrobial Substances

The Utilization of Herbs and Spices for Antimicrobial Applications

Harnessing the Antibacterial Potentials of Fruits and Vegetables

Antimicrobial Properties in Seeds and Foliage

Antimicrobial Substances Sourced from Animals

ANTIMICROBIAL COMPOUNDS ORIGINATING FROM MICROORGANISMS

Categorizing Natural Compounds with Antimicrobial Properties

Understanding the Mechanisms of Action of Natural Antibacterial Agents

Influential Factors in the Antibacterial Activity of Natural Products

Methods of Extracting Natural Antibacterial Compounds

Increasing Resistance to Natural Products

PUBLIC PERCEPTION AND CONCERNS REGARDING ADVERSE EFFECTS OF NATURAL ANTIMICROBIALS

Human Diseases and Recent Biotechnology Breakthroughs in Curbing Diseases

Ana K. Villagómez-Guzmán1,* and Israel Valencia Quiroz2

CVD: THE LEADING CAUSE OF DEATH WORLDWIDE

CANCER: ONE OF THE MOST COMMON AND DEVASTATING DISEASES

DIABETES: ONE OF THE MOST PREVALENT AND DEADLY HUMAN DISEASES

HIV: ONE OF THE MOST PREVALENT AND DEADLY HUMAN DISEASES

COVID-19: ONE OF THE DEADLIEST HUMAN INFECTIOUS DISEASES

NEXT-GENERATION NANOMEDICINES AND COMBINATION THERAPIES: BRIDGING THE GAP IN GLOBAL HEALTH EQUITY

Alzheimer's Disease and Dementia: Rising Global Prevalence and Innovative Genome Editing Approaches

Advanced Therapy Medicinal Products: Harnessing Gene Therapy for Disease Treatment

Immunotherapy: A Paradigm Shift in Cancer Treatment

Precision Medicine: The Future of Individualized Treatment Strategies

Harnessing Biotechnology in the Battle Against Infectious Diseases

Utilizing Biotechnology in the Development of Treatments for Chronic Diseases Such as Cancer.

Leveraging Biotechnology in the Development of Treatments for Diabetes Mellitus

NAVIGATING CHALLENGES OF BIOTECHNOLOGY IN DRUG DEVELOPMENT: COST, ACCESS, AND ETHICAL CONCERNS

ROLE OF MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE IN THE ADVANCEMENT OF BIOLOGICS, CELL TREATMENTS, AND DRUG DISCOVERY

ACKNOWLEDGMENTS

Exploring the Intersection of Omics Technologies and Biotechnology in Drug Interaction Studies

Israel Valencia Quiroz1,*

USING HIGH-THROUGHPUT SCREENING TO FIND NEW DRUGS

Personalized Medicine and Pharmacogenomics

Drug-drug and Drug-metabolite Interactions

Drug Repurposing and Polypharmacology

Systems Biology and Network Analysis

Microbial Biotechnology and Drug Interactions

ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS (ELSI) OF OMICS TECHNOLOGIES IN BIOTECHNOLOGY

FUTURE PERSPECTIVES AND CHALLENGES

Sharing is Caring: Drug Repurposing among Leading Diseases

Verónica García-Castillo1, Eduardo López-Urrutia1, Carlos Pérez-Plasencia1,2 and Adriana Montserrat Espinosa-González3,*

THE PANDEMIC IN THE ROOM

ANTI-DIABETICS: DRUGS TO RULE THEM ALL?

DO NOT FORGET TO REPURPOSE FOR ALZHEIMER'S DISEASE

ACKNOWLEDGEMENTS

Subject Index

Back Cover.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815223163

981522316X

OCLC:

1428258435