Plant-Based Drug Discovery : Unveiling Molecular Targets for Metabolic Conditions.

Format:

Book

Author/Creator:

Bisht, Mamta.

Contributor:

Singh, Ajay.

Srivastava, Akhileshwar Kumar.

Language:

English

Physical Description:

1 online resource (870 pages)

Edition:

1st ed.

Place of Publication:

Chantilly : Elsevier Science & Technology, 2025.

Summary:

Plant-Based Drug Discovery: Unveiling Molecular Targets for Metabolic Conditions provides an in-depth examination of the molecular mechanisms of phytochemicals and their potential in treating metabolic diseases.

Contents:

Front Cover

Half title

Title

Copyright

Contents

Contributors

Biography

Preface

Acknowledgment

Section I Introduction

Chapter 1 Overview of lifestyle-related metabolic disorders

1.1 Introduction

1.2 Common metabolic disorders associated with lifestyle

1.2.1 Obesity

1.2.2 Diabetes mellitus

1.3 β-cell dysfunction

1.3.1 Metabolic syndrome

1.3.2 Non-alcoholic fatty liver disease (NAFLD)

1.4 Conclusion

References

Section II Phytochemicals and molecular targets

Chapter 2 Significance of phytochemicals in metabolic disorders

2.1 Introduction

2.2 What are phytochemicals?

2.3 Classes of phytochemicals

2.4 Phytochemicals in management of metabolic disorders

2.4.1 Blood sugar regulation and glycemic control

2.4.2 Obesity and weight management

2.4.3 Hypertension or high blood pressure

2.4.4 Lipid metabolism: Balancing cholesterol and triglycerides

2.4.5 Anti-inflammatory agents

2.4.6 Cardiovascular health

2.4.7 Free radical formation

2.4.8 Gut health and microbiota modulation

2.5 Practical approaches: Integrating phytochemicals into everyday life

2.5.1 Dietary recommendations for phytochemical intake

2.6 Lifestyle changes for comprehensive metabolic health

2.7 Challenges and future directions

2.7.1 Current challenges in utilizing phytochemicals for metabolic health

2.7.2 The road ahead: Personalized approaches and innovative solutions

2.8 Conclusion

Chapter 3 Exploring the role of phytochemicals in managing metabolic disorders

3.1 Introduction

3.1.1 Metabolic syndrome

3.1.2 Prevalence of metabolic syndrome

3.1.3 Diagnosis of metabolic syndrome

3.1.4 Management of metabolic syndrome

3.1.5 Medicinal plants and metabolic syndrome

3.1.6 Metabolic syndrome and inflammation.

3.1.7 Significance of botanicals in the management of inflammation

3.1.8 Metabolic syndrome and oxidative stress

3.1.9 Botanicals and management of oxidative stress

3.1.10 Metabolic syndrome and infertility

3.1.11 Botanicals and treatment of infertility

3.1.12 Diabetes and botanicals

3.1.13 Diabetes as metabolic syndrome

3.1.14 Botanicals and management of diabetes

3.1.15 Metabolic syndrome and hypertension

3.1.16 Hypertension and botanicals

3.1.17 Botanicals and management of hypertension

3.1.18 Dyslipidemia and botanicals

3.1.19 Dyslipidemia as metabolic syndrome

3.1.20 Botanicals and management of dyslipidemia

3.2 Conclusion

Chapter 4 Enhancing understanding of phytochemicals' role in managing metabolic disorders

4.1 Introduction

4.2 Types of phytochemicals and their biological properties

4.2.1 Polyphenols

4.2.2 Alkaloids

4.2.3 Terpenes

4.3 Mechanisms of action of phytochemicals in metabolic regulation

4.3.1 Antioxidant activity

4.3.2 Anti-inflammatory effects

4.3.3 Insulin sensitization

4.3.4 Lipid metabolism regulation

4.4 Phytochemicals and gut health

4.4.1 Interaction with gut microbiota

4.4.2 Role in modulating glucose

4.4.3 Effect of phytochemical in lipid metabolism and NAFLD

4.5 Evidence from preclinical and clinical studies

4.6 Challenges in phytochemical research

4.6.1 Bioavailability challenges

4.6.2 Metabolism challenges

4.6.3 Variability in phytochemical content

4.6.4 Interaction with dietary components

4.6.5 Long-term safety concerns

4.7 Conclusion

Chapter 5 Molecular connection of oxidative stress and metabolic syndrome: Therapeutic role of phytocomponents

5.1 Introduction

5.2 Metabolic disorder: A complex disorder

5.2.1 Lifestyle: Primary cause of metabolic disorder.

5.3 Oxidative stress: The underlying mechanism

5.3.1 Cytochrome P450

5.3.2 NADPH Oxidase (NOX)

5.3.3 Cyclooxygenases (COX)

5.3.4 Monoamine Oxidases A and B (MAOA and MAOB)

5.4 Therapeutic strategies using antioxidants

5.4.1 SOD and SOD-catalase mimics

5.4.2 Glutathione peroxidase mimics

5.4.3 Increasing GSH

5.4.4 NRF2 activators

5.5 Nutraceuticals intervention for metabolic syndrome

5.5.1 Polyphenols

5.5.2 Saponins

5.5.3 Anthocyanins

5.5.4 Terpenoids

5.6 Conclusion

Chapter 6 Epigenetic mechanisms of phytochemicals in the cure of metabolic diseases

6.1 Introduction

6.2 Types of epigenetic modifications

6.2.1 Histone modifications

6.2.2 DNA modifications

6.2.3 Posttranslational modifications

6.3 Phytochemicals and epigenetic modulation of metabolic diseases

6.3.1 Resveratrol

6.3.2 Curcumin

6.4 Other significant phytochemicals and their epigenetic effects

6.4.1 Polyphenols

6.4.2 Flavonoids

6.4.3 Isoflavones

6.4.4 Sulforaphane

6.4.5 Organosulfur compounds

6.5 Conclusions

Chapter 7 Epigenetics mechanisms of phytochemicals in cure of metabolic diseases

7.1 Introduction

7.1.1 Overview of epigenetics

7.2 Methods

7.2.1 Methods to study epigenomic and epigenetic states

7.2.2 Epigenetic regulatory mechanisms

7.2.3 Mechanisms of phytochemicals in cure of metabolic diseases

7.2.4 Utilizing phytochemicals to control metabolic processes

7.2.5 Pancreatic lipase activity

7.2.6 Thermogenesis and lipid metabolism

7.2.7 Epigenetics and epigenetic action mechanisms

7.2.8 Inheritance of epigenetic modifications

7.2.9 Herbal compounds and epigenetics

7.3 Conclusion

Chapter 8 Plant&amp

#x2011

derived bioactive peptides for treatment of metabolic disorders

8.1 Introduction.

8.2 Metabolic effects of bioactive peptides

8.3 Plant sources

8.4 Major biological functions of bioactive peptides of plant origin

8.4.1 Antidiabetic effect of plant peptide

8.4.2 Antidiabetic peptides' mode of action against type 2 diabetes

8.4.3 Plant peptides' effects in lowering triacylglycerol and preventing obesity

8.4.4 Plant peptides that inhibit fatty acid synthase and anti-obesity peptides that lower appetite

8.4.5 Plant peptides' ability to reduce cholesterol

8.5 Diversity in the production of bioactive peptides

8.6 Purification and characterization of bioactive peptides

8.7 Challenges and research opportunities during industrial application

8.7.1 Stability of bioactive peptide

8.8 Future prospects

8.9 Discussion

8.10 Conclusion

Chapter 9 Efficiency of phytochemicals to cure metabolic diseases by targeting mitophagy

9.1 Introduction

9.2 Materials and methods

9.2.1 GO analysis

9.2.2 Target protein preparation

9.2.3 Ligand preparation

9.3 Results and discussion

9.3.1 GO analysis

9.4 Molecular docking

9.5 Conclusion

Abbreviations

Chapter 10 The potential of phytochemicals in mitophagy-driven treatment of metabolic diseases

10.1 Introduction

10.1.1 Metabolic disease

10.1.2 Mitophagy

10.2 Regulation of mitophagy

10.2.1 AMPK/mTOR pathway

10.2.2 PTEN-induced Kinase 1/Parkin mediated pathways

10.2.3 BNIP3 and NIX-mediated pathway

10.2.4 FUNDC1 Receptor-mediated signaling pathway

10.3 Phytochemical targeting mitophagy

10.4 Therapeutic potential of phytochemicals against metabolic diseases

10.4.1 Obesity

10.4.2 Type 2 diabetes

10.4.3 Nonalcoholic fatty liver disease

10.4.4 Cardiovascular disease

10.5 Conclusion

References.

Chapter 11 Phytochemicals as promising therapeutic approaches for inflammasomes-related metabolic disorders

11.1 Introduction

11.1.1 Overview of metabolic diseases and their association with IM activation

11.1.2 Importance of phytochemicals as potential therapeutic agents

11.2 Role of inflammasomes in metabolic disorders

11.2.1 Molecular pathways linking inflammasome activation to metabolic dysfunction

11.3 Phytochemicals with anti-inflammasome activity

11.3.1 Berberine

11.3.2 Resveratrol

11.3.3 Emodin

11.3.4 Ellagic acid

11.3.5 Epigallocatechin gallate

11.3.6 Curcumin

11.3.7 Baicalein

11.3.8 Chrysin

11.4 Potential synergistic effects of phytochemical combinations

11.5 Patented technologies

11.6 Conclusions and future perspectives

Chapter 12 Regulatory impact of phytochemicals on metabolic diseases by targeting Nrf2-ARE signaling mechanism

12.1 Introduction

12.2 Nrf2 pathway regulation

12.3 KEAP-1-mediated regulation of Nrf2 pathway

12.4 Nrf2:KEAP-1 pathway in cancer cells

12.5 Phytochemicals: As therapeutic repository

12.6 Nrf2 activators

12.7 Sulforaphane [1-isothiocyanato-4-(methylsulfonyl)-butane] (SFN)

12.8 Oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole- 3-thione) (OPZ)

12.9 Epigallocatechin-3-gallate (EGCG)

12.10 Dimethyl fumarate (tecfidera or DMF)

12.11 Diallyl trisulfide (DATS)

12.12 Curcumin (CUR)

12.13 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO)

12.14 Apigenin (4,5,7-trihydroxyavone (Api))

12.15 Resveratrol (3,5,4-trihydroxystilbene (RES))

12.16 Quercetin

12.17 Nrf2 inhibitors

12.18 Brusatol (BRU)

12.19 Luteolin (3′,4′,5,7-tetrahydroxyflavone (LUT))

12.20 Trigonelline (TRG)

12.21 Ascorbic acid (vitamin C, L-ascorbic acid, AscA, AA)

12.22 Retinoic acid (RA).

12.23 Chrysin (5,7-dihydroxy-2-phenyl-4H-chromen-4-one (CHR)).

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

0-443-31699-6

0-443-31698-8

OCLC:

1537943223