Continuous biopharmaceutical processes : chromatography, bioconjugation, and protein stability / David Pfister, Lucrèce Nicoud, Massimo Morbidelli.

Format:

Book

Author/Creator:

Pfister, David, 1988- author.

Nicoud, Lucrèce, 1988- author.

Morbidelli, Massimo, author.

Series:

Cambridge series in chemical engineering.

Cambridge series in chemical engineering

Language:

English

Subjects (All):

Protein drugs.

Pharmaceutical technology.

Physical Description:

1 online resource (xix, 327 pages) : digital, PDF file(s).

Place of Publication:

Cambridge : Cambridge University Press, 2018.

Summary:

This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.

Contents:

Introduction to biopharmaceutical processes

Fundamentals of protein chromatography

Counter-current separation processes

Counter-current chromatography for the capture step

Counter-current chromatography for the polishing steps

Protein conjugation

Protein aggregation in biopharmaceutical processes.

Notes:

Title from publisher's bibliographic system (viewed on 24 Sep 2018).

Includes bibliographical references and index.

ISBN:

1-108-33289-7

1-108-34978-1

1-108-35218-9