The Role of Chromenes in Drug Discovery and Development / edited by Ashutosh Kumar Dash and Deepak Kumar.

Format:

Book

Author/Creator:

Dash, Ashutosh Kumar, Author.

Contributor:

Dash, Ashutosh Kumar, editor.

Kumar, Deepak, editor.

Language:

English

Subjects (All):

Drug development.

Physical Description:

1 online resource (302 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers Pte. Ltd., 2023.

Summary:

Chromene is a naturally abundant heterocyclic compound found in alkaloids, tocopherols, terpenes and other compounds. Its derivatives can be used as a scaffold that exhibits pharmacological activity in the human body. Chromene drugs and related bioactive molecules are the prime focus of this reference. It presents 13 thoroughly researched chapters that comprehensively cover all aspects about the molecule. Starting with a detailed introduction to its role and importance in drug discovery, the book goes into the details of chromene structure, synthesis and pharmacology. Readers can gain knowledge of different commercial medicines based on chromene and its pharmacological activity against different diseases. The elaborate topics in the book will help researchers working on chromene based drugs. Key highlights of the book include: - Complete coverage of chromene's role in nature and drug development with references to historical background and current developments - References to commercial and preclinical drugs and patents of interest - Explanation of chromene bioacivity in different diseases (antioxidant, antidiabetic, antinflammatory, antibacterial and antifungal activities, antitumour, immunomodulatory activity) - Explanation of chromene activity against SARS-Cov2.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Chromene and its Importance: Chemistry and Biology

Nitin Verma1,*, Parul Sood1, Jitender Singh2, Niraj Kumar Jha3, Mahesh Rachamalla4 and Kamal Dua5

INTRODUCTION

CHROMENE-CONTAINING PLANTS

PHARMACOLOGICAL ACTIVITY

Anti-Alzheimer Activity

Antimicrobial

Anticancer

Anti-inflammatory

Antioxidant

Anti-plasmodial Activity

Leishmanicidal Activity

Anti-trypanocidal Activity

CONCLUSION

ACKNOWLEDGEMENT

REFERENCES

Recent Trends of Chromene Syntheses

Samarpita Das1, Pulkit Asati1, Harish K. Indurthi1, Ashutosh Kumar Dash2 and Deepak K. Sharma1,*

SYNTHETIC STRATEGIES

Organocatalyst Approaches

Synthesis of Substituted 4H-Chromenes using Acetic Anhydride

Synthesis of Functionalized 4H-Chromenes in Presence of Thiourea Generated by AI.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

ISBN:

9789815124330

9815124331

OCLC:

1399170452