Therapeutic drug targets and phytomedicine for triple negative breast cancer / Acharya Balkrishna.

Format:

Book

Author/Creator:

Balkrishna, Acharya, author.

Language:

English

Subjects (All):

Breast--Cancer.

Breast.

Physical Description:

1 online resource (230 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2023]

Summary:

Triple negative breast cancers (TNBC) are a biologically aggressiveform of breast cancer and constitute approximately 10-15% of all breast cancerpatients. Distant metastasis, lack of clinically targeted therapies andprognostic markers, makes the disease difficult to treat. Till now not muchwork has been carried out on this deadly disease. This book provides an overview of TNBC etiology, its treatmentstrategies and prognostic markers to identify the outcome of standard therapies.Signalling pathways namely cell proliferation, angiogenesis, invasion andmetastasis, apoptosis, autophagy and others involved in complicating thedisease have been described in the chapters to convey an understanding aboutthe disease mechanisms. All the possible drugs either in pre-clinical orclinical stages have also been mentioned with data that depicts their efficiencyin targeting altered genes. The book also introduces the reader to herbalmedicine exhibiting high potency to target TNBC, their synthetic analogs usedduring chemotherapy and their ability to fight against chemoresistance. Theconcept of phytonanotechnology has also been discussed. The book helps createawareness among a broad range of readers about TNBC. It points to prioritizingthe upgradation of health care facilities and re-designing future treatmentstrategies to provide maximum benefit to breast cancer patients.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Etiological Insights into TNBC and their Related Catastrophic Risks

Haritha H Nair1 and Ruby John Anto1,*

INTRODUCTION

Epigenetic Profiling of Triple Negative Breast Cancer

DNA Methylation Altering Triple Negative Breast Cancer Expression

Histone Modification Altering Triple Negative Breast Cancer

miRNA Altering Triple Negative Breast Cancer

Long Non-coding RNA Signature Altering Triple Negative Breast Cancer Expression

An Insight of Molecular Characterization of Triple Negative Breast Cancer

MOLECULAR CLASSIFICATION OF TRIPLE NEGATIVE BREAST CANCER

Basal Like (BL1 &amp

BL2) Subtype of Triple Negative Breast Cancer

Immunomodulatory Subtype of Triple Negative Breast Cancer

Mesenchymal and Mesenchymal Stem Like Subtype of Triple Negative Breast Cancer

Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer

Claudin Low Subtype of Triple Negative Breast Cancer

HETEROGENEOUS NATURE OF TRIPLE NEGATIVE BREAST CANCER: A STUMBLING BLOCK

POSSIBILITY OF SURVIVAL IN TRIPLE NEGATIVE BREAST CANCER

UPDATES OF TRIPLE NEGATIVE BREAST CANCER ACROSS THE GLOBE

Prevalence of Triple Negative Breast Cancer Amongst Barbadian Women

Prevalence of Triple Negative Breast Cancer Amongst African Women

Prevalence of Triple Negative Breast Cancer Amongst Oman Women

Prevalence of Triple Negative Breast Cancer Amongst New Zealand Women

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

ABBREVIATIONS

REFERENCES

A Clinical Cognizance of Molecular and Pathological Diagnostic Approach of TNBC

Acharya Balkrishna1,2, Usman Umar Zango3, Saima Kauser Nasir4 and Vedpriya Arya1,*

INTRODUCTION.

CLINICO-PATHOLOGICAL CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER

Immunohistochemistry of Triple Negative Breast Cancer

GENOMIC CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER

Analysis of Emerging Mutations in Triple Negative Breast Cancer

Biology of Circulating Tumor DNA and its Implication in Characterization of Triple Negative Breast Cancer

PROTEOMIC CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER

TRANSCRIPTOMIC ANALYSIS OF TRIPLE NEGATIVE BREAST CANCER

RADIOLOGICAL CHARACTERIZATION OF TRIPLE NEGATIVE BREAST CANCER

MRI Analysis of Triple Negative Breast Cancer

Mammography of Triple Negative Breast Cancer

Molecular Sub-Typing and Exploration of Key Signalling Pathways Involved in Complicating the Disease

Nikhil Ponnoor Anto1, Amitha Muraleedharan2 and Rashmi Mittal3,*

Aetiology of Triple Negative Breast Cancer Subtypes

Sub-Classification of Triple Negative Breast Cancer on Basis of Aberrated Copy Number

Sub-Classification of Triple Negative Breast Cancer on Basis of Histology

Sub-Classification of Triple Negative Breast Cancer on Basis of Proteome Analysis

Sub-Classification of Triple Negative Breast Cancer on Basis of Mutations

MOLECULAR SIGNALING PATHWAYS INVOLVED IN TRIPLE NEGATIVE BREAST CANCER

Role of Angiogenesis in Complicating Triple Negative Breast Cancer

Role of Altered Apoptosis in Complicating Triple Negative Breast Cancer

Role of Altered Autophagy in Complicating Triple Negative Breast Cancer

Role of Metastasis in Complicating Triple Negative Breast Cancer Cells

Role of Molecular Signaling Pathways Involved in Complicating Triple Negative Breast Cancer.

IDENTIFICATION OF OTHER GENES AND SIGNALING PATHWAYS INVOLVED IN COMPLICATING TNBC

Role of Androgen Receptors in Complicating TNBC

Role of miRNAs in Triple Negative Breast Cancer

Role of Estrogen Receptor Related Receptor in Complicating Triple Negative Breast Cancer

Role of other Signaling Pathways in Complicating Triple Negative Breast Cancer

Pre-Clinical and Clinical Evidence of Recent Therapeutic Trends and Spotting Possibility of Cure in Near Future

Amitha Muraleedharan1, Sagar Kumar2 and Rashmi Mittal2,*

Current Paradigm of Therapeutic Approach Against Triple Negative Breast Cancer

Surgery in Triple Negative Breast Cancer Cases

Radiotherapy in Triple Negative Breast Cancer

Chemotherapy in Triple Negative Breast Cancer

PRE-CLINICAL AND CLINICAL EVIDENCE OF THERAPEUTIC REGIMENS AGAINST TRIPLE NEGATIVE BREAST CANCER

Anti-angiogenic Agents in Treatment of Triple Negative Breast Cancer

Anti-Androgen Receptors against Triple Negative Breast Cancer

Apoptosis Inducing Drugs against Triple Negative Breast Cancer

Immunomodulatory Agents against Triple Negative Breast Cancer

Cell Cycle Inhibitors for Triple Negative Breast Cancer

Inhibitors of Pro-Survival Signalling Pathways in Triple Negative Breast Cancer

COMBINATIONAL THERAPEUTIC APPROACH AGAINST TRIPLE NEGATIVE BREAST CANCER

Evaluating Fate of Emerging Resistance Hitting the Brakes on Conventional Treatment Approach

Nikhil Ponnoor Anto1 and Rashmi Mittal2,*

AN INSIGHT OF FACTORS RESPONSIBLE BEHIND CHEMORESISTANCE IN TRIPLE NEGATIVE BREAST CANCER.

Role of Cancer Stem Cell in Inducing Resistance

Role of Hypoxia in Inducing Resistance

Role of Enhanced Lysosomal Biomass in Inducing Resistance

Role of Metabolic Interaction with Tumor-Associated Macrophages in Inducing Resistance

Role of PTEN and PI3k/Akt/mTOR Pathway in Inducing Resistance

Role of ABC Transporters in Inducing Resistance

MOLECULAR SIGNATURES OF CHEMOSENSITIVITY IN TRIPLE NEGATIVE BREAST CANCER

Altered miRNA Expression as Predictor of Chemoresistance

Analysis of Transcriptional Signatures as Predictor of Chemoresistance

Role of Tumor Infiltrating Lymphocytes as Predictor of Chemoresistance

DRUG REPURPOSING IN TRIPLE NEGATIVE BREAST CANCER

COMBINATIONAL TARGETED AND BIOLOGICAL THERAPIES TO OVERCOME TRIPLE NEGATIVE BREAST CANCER

Herbal Medicine: Prejudice to Realm of Reality Against TNBC

Balachandran S. Vinod1 and Ruby John Anto2,*

NATURAL PRODUCTS AGAINST TRIPLE NEGATIVE BREAST CANCER

Role of Polysaccharides in Targeting Triple Negative Breast Cancer

Role of Phenols in Targeting Triple Negative Breast Cancer

Role of Saponins in Targeting Triple Negative Breast Cancer

Role of Flavonoids in Targeting Triple Negative Breast Cancer

Role of Taxanes in Targeting Triple Negative Breast Cancer

ROLE OF HERBAL MEDICINES IN TARGETING MOLECULAR SIGNALLING PATHWAYS INVOLVED IN TRIPLE NEGATIVE BREAST CANCER

Role of Herbal Medicine in Targeting Angiogenesis

Role of Herbal Medicine in Arresting Cell Cycle

Role of Herbal Medicine in Inducing Metastasis

Role of Herbal Medicine in Inducing Apoptosis

Role of Herbal Medicine in Inducing Autophagy

POTENTIAL ROLE OF HERBAL MEDICINE IN TARGETING SIGNALLING PATHWAYS IN TRIPLE NEGATIVE BREAST CANCER.

Herbal Medicine Targeting Akt/mTOR/NF-kB Signalling Pathways

Herbal Medicine Targeting STAT3 Signalling

Herbal Medicine Targeting Wnt/β-Catenin Sigalling Pathway

COMBINATIONAL THERAPEUTIC APPROACH AGAINST TRIPLE NEGATIVE BREAST CANCER USING HERBAL MEDICINE

Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics

Sreekumar Usha Devi Aiswarya1 and Smitha V. Bava1,*

Phyto-Constituents as Genetic or Epigenetic Modulator of TNBC

Phytochemicals Induced Demethylation in Triple Negative Breast Cancer

Phytochemical Induced Histone De-acetylation in TNBC

PHYTOCHEMICAL MEDIATED INHIBITION OF MOLECULAR TARGETS IN TRIPLE-NEGATIVE BREAST CANCER

Phytochemical Mediated Inhibition of Cell Proliferation in TNBC

Phytochemical Mediated Inhibition of Metastasis in TNBC

Phytochemical Mediated Induction of Apoptosis in TNBC

Phytochemicals Induced Autophagy in TNBC

Phytochemical Mediated Inhibition of Angiogenesis in TNBC

COMBINATIONAL DRUG THERAPY TO RE-SENSITIZE CONVENTIONAL DRUG TARGETS USING HERBAL MEDICINE AGAINST TNBC

Combinational Therapy Comprising Herbal Medicine Along with Doxorubicin Against TNBC

Combinational Therapy Comprising Herbal Medicine Along with Docetaxel Against TNBC

Combinational Therapy Comprising Herbal Medicine Along with Paclitaxel Against TNBC

Combinational Therapy Comprising Herbal Medicine Along with Bicalutamide

POSSIBLE CHALLENGES LIMITING APPLICATION OF PHYTOCHEMICALS AGAINST TNBC

Limiting Solubility and Poor Absorption of Phytochemicals in TNBC

REFERENCES.

Phyto-nanotechnology: Enhancing Plant Based Chemical Constituent Mediated Anticancer Therapies.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815079784

9815079786

OCLC:

1370496797