Natural products for the management of arthritic disorders. Volume 5. / Rupesh K. Gautam, Lokesh Deb, and Kamal Dua.

Format:

Book

Author/Creator:

Gautam, Rupesh K., author.

Deb, Lokesh, author.

Dua, Kamal, author.

Series:

Frontiers in Arthritis

Language:

English

Subjects (All):

Rheumatoid arthritis.

Physical Description:

1 online resource (292 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2022]

Summary:

Rheumatoid arthritis (RA) is the most common inflammatory complication and affects approximately 1 % of the global population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF‐α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not a cure for the complications, and antibody therapy and surgical procedures are expensive. However, in the present era, researchers and healthcare professionals have moved toward natural medicines obtained from plants and other natural sources. Research based on developments in phytomedicine has progressed steadily. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. Researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects. Natural Products for the Management of Arthritic Disorders compiles current knowledge about the bioactive compounds and herbal formulations useful in the treatment of rheumatoid arthritis. 11 chapters explain the role of natural products in the management of rheumatoid arthritis. Topics have been contributed by experts in medicinal chemistry and rheumatology. The book first introduces the reader to rheumatoid arthritis before delving into conventional and alternative therapies for the disease. The editors have also included special topics such as the biomarkers for RA,

cytokines and anti-inflammatory mediators, preclinical and clinical studies. The range of topics should provide a comprehensive overview of natural remedies for arthritis and the role of natural products in anti-arthritic drug development. The information will be useful for many readers including medical and pharmacology students, multidisciplinary research scholars, scientists, pharma / herbal / food industrialists, and policy makers.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Rheumatoid Arthritis: Introduction

Diptendu Bhowmik1, Venu Kola1, Subba Rao Chamakuri2 and Chiranjib Bhattacharjee1,*

INTRODUCTION

TYPES OF RHEUMATOID ARTHRITIS [4, 5]

Seropositive

Seronegative

Miscellaneous Type

RHEUMATOID ARTHRITIS SUB-TYPES

EPIDEMIOLOGY

SYMPTOMS

ETIOLOGY

Genetic

Hormonal

Immunologic Factors

Environmental Influences

Socioeconomic Factors

Psychological Factors

RISK FACTORS

Age and Sex [20, 63]

Infections and the Microbiome

Periodontitis

Bodyweight

COMPLICATIONS OF RHEUMATOID ARTHRITIS

Widespread Inflammation

Joint Damage

Cardiovascular Disease

Cervical Myelopathy

Effects on Skin

Eye Complications

Neck Pain

Blood Vessel and Heart Disease

Lung Problems

Osteoporosis

Diabetes

Emotional Effects

RHEUMATOID ARTHRITIS DIAGNOSIS

DIAGNOSTIC CRITERIA

DIAGNOSTIC TESTS

DIFFERENTIAL DIAGNOSIS

Medical History

Physical Examination

Blood Tests

Imaging Tests

RHEUMATOID ARTHRITIS PREVENTION

CONCLUSION

ABBREVIATIONS

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Conventional Therapy for Rheumatoid Arthritis

Anil T. Pawar1, Akshay M. Baheti1,*, Pallavi Adate-More1 and Aman Upaganlawar2

CONVENTIONAL THERAPY FOR RHEUMATOID ARTHRITIS

Anti-inflammatory Agents

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Glucocorticoids

Disease-Modifying Anti-rheumatic Drugs

Biological DMARDs

Role of Biomarkers in Rheumatoid Arthritis

Hitesh Malhotra1,* and Anjoo Kamboj2

BIOMARKERS.

Tumour Necrosis Factor-Alpha (TNF-α)

Interferon (INF)

Interleukin-1 (IL-1)

Interleukin-6 (IL-6)

Interleukin-12 (IL-12)

Interleukin-15 (IL-15)

Interleukin-17 (IL-17)

Interleukin-18 (IL-18)

Bioactive Compounds in Rheumatoid Arthritis

Sudha Vengurlekar1,* and Subhash Chandra Chaturvedi1

BIOACTIVE COMPOUNDS IN RHEUMATOID ARTHRITIS

Polyphenols

Flavonoids

Anthocyanin

Fatty Acid

Alkaloids

Saponins

Terpenoids

BIOACTIVE COMPONENTS FROM ESSENTIAL OILS

β-Caryophyllene

Eucalyptol

Cinnamaldehyde

Nerolidol

Eugenol

Thymoquinone

Sclareol

Traditional Medicinal Plants: Safe and Efficacious Potential Drugs in the Management of Rheumatoid Arthritis

Sarath Nalla1,*, Sahdeo Prasad2, Lakshmi Kavuri2 and Vijetha Pendyala3

TREATMENT STRATEGIES

ALPINIA GALANGA (LINN.)

AQUILARIA AGALLOCHA ROXB

BOSWELLIA SERRATAROXB

CEDRUS DEODARA(ROXB.) LOUD

CHAMAECYPARIS OBTUSA (SIEBOLD &amp

ZUCC.) ENDL

CINNAMOMUM ZEYLANICUM L

COMMIPHORA MUKUL (STOCKS) HOOK.

CURCUMA LONGA L

CYPERUS SPP

GAULTHERIA FRAGRANTISSIMAWALL

GLYCYRRHIZA GLABRA L

HIBISCUS PLATINIFOLIUS LINN

JUSTICIA GENDARUSSA BURM. F

LITSEA CUBEBA (LOUR.) PERS

OCIMUM AMERICANUM L

PIPER NIGRUM L

POLYGONUM VIVIPARUML

RHAPHIDOPHORA GLAUCA (WALL.) SCHOTT

STEUDNERA COLOCASIIFOLIA K.KOCH

RHODODENDRON TOMENTOSUM HARMAJA

STROBILANTHUSIXIO CEPHALA BENTH

STRYCHNOS POTATORUM (LINN.)

URTICA PILULIFERA L

ZINGIBER OFFICINALE ROSCOE

ACKNOWLEDGEMENTS.

REFERENCES

Inflammatory Mediators and Cytokines involved in Rheumatoid Arthritis

Vikash Sharma1, Shiv Shankar Shukla2, Amber Vyas3 and Ravindra Kumar Pandey4,*

PATHOPHYSIOLOGY

CYTOKINES IN RA

Cytokines

PRO-INFLAMMATORY CYTOKINES IN RA

Tumor Necrosis Factor-α

ANTI-INFLAMMATORY CYTOKINES IN RA

Interleukin-10 (IL-10)

Interleukin-4 and 13 (IL-4 and IL-13)

PRO- AND ANTI-INFLAMMATORY CYTOKINES IN RA

Transforming Growth Factor-Beta (TGF-β)

INTERFERON-ϒ (IFN- ϒ)

INFLAMMATORY MEDIATORS

Eicosanoids

Cyclooxygenase

PROSTAGLANDINS

LIPOXYGENASE

TRANSCRIPTION FACTORS IN INFLAMMATION AND ARTHRITIS

Nuclear factor NF-κB

STATS

TOLL-LIKE RECEPTORS (TLR)

Natural Products Targeting Various Mediators in Rheumatoid Arthritis

Disha Arora1,*, Sanjay Sharma2 and Sumeet Gupta3

HERBAL FORMULATIONS IN CLINICAL USAGE

NATURAL PRODUCT DELIVERY BY NANOTECHNOLOGY

Herbal Formulations Useful in the Treatment of Rheumatoid Arthritis

Akshay M. Baheti1, Anil T. Pawar1,* and Aman Upaganlawar2

HERBAL FORMULATIONS FROM AYURVEDA SYSTEM OF MEDICINES

Choorna

Ajmodadi Choorna

Amrutadyam Choorna (Amrutadi churna)

Alambusadi Choorna

Bhallaatakaadi Choorna

Chitrakadi Choorna

Hingwadi Choorna

Panchasama Choorna

Pathyadi Choorna

Pippali Choorna

Punarnavadi Choorna

Panchkola Choorna

Trikatu Choorna

Vaishwanar Choorna

Vatika and Gutika

Alambushadi Ghana Vati

Amavata Pramathini Vati

Patoladi Yoga Tablet

Shatapatrayadi Churna tablet.

Rasona Pinda

Decoctions (Kvaatha)

Rasonadi Kwath

Shunthi-Gokshura Kwatha

Rasna Saptak Kwath

Shigru Twak Kwath

Mahaushadhi Kwath

Balaguluchyadi Kashyam and Punarnavadi Kashyam

Guduchi Kwath (Tinospora cordifolia (Thunb.) Miers) and Shunti Kwath (Zingiber officinale Roscoe)

Medicated Ghee (Ghrita) and Medicated Oils (Taila)

Amrita Ghrita

Eranda Taila

Saindavadi Taila

Guggul (Guggulu)

Shiva Guggul

Simhanaada Guggul

Vatari Guggul

Yograj Guggul

HERBAL FORMULATIONS FROM UNANI SYSTEM OF MEDICINES

Majoon-e-Kundur

Majoon Suranjan

Habb-e-Asgand

UNIM-301

Qurs-e-Mafasil

HERBAL FORMULATIONS FROM SIDDHA SYSTEM OF MEDICINES

Kalpaamruthaa

Mudakuvatha Legium

Karpoora Chindaani Mathirai

Mannennaikalavai Thylam

Amukkara Choornam

Vayu KeelagaIlagam

HERBAL FORMULATIONS FROM CHIENESE TRADITIONAL MEDICINES

Huo Luo Xiao Ling Dan

Gui-Zhi-Shao-Yao-Zhi-Mu Decoction

Fengshiding Capsule

Bi-Qi Capsule

Han Shi Bi Pill

Tong Bi Capsule

MARKETED HERBAL FORMULATIONS FOR RHEUMATOID ARTHRITIS

Rumalaya Forte

Rumalaya Liniment

Articulin Forte

Sudard

Rheuma off Gold

Jointeez

Arthosansar

Rhumapar Tablet

Arthrella Tablet

Rumaxel Gel

Rheumartho Gold

Rumogin Capsule

Amvatantak Churna

Rheumatil Oil and Tablet

Artilon Capsule

Joint Care Capsule

LIST OF ABBREVIATIONS

Preclinical and Clinical Studies on Natural Products Used in Rheumatoid Arthritis

Anil Kamboj1 and Randhir Singh2,*

SYMPTOMS AND DIAGNOSIS

MEDICATIONS

SURGICAL PROCEDURES AND OTHER TREATMENTS

CLASSIFICATION

NEED OF THE NATURAL PRODUCTS FOR THE MANAGEMENT AND TREATMENT OF RA

ABBREVATIONS

CONSENT FOR PUBLICATION.

CONFLICT OF INTEREST

Phytochemicals: A New Approach for Targeting Biomarkers in the Management of Arthritis

Hitesh Malhotra1,*, Anjoo Kamboj2 and Peeyush Kaushik1

PHYTOCHEMICALS: A POTENT THERAPEUTIC AGENT

ALLICIN

ANDROGRAPHOLIDE

BERBERINE

BROMELAIN

CELASTROL

CHLOROGENIC ACID

CURCUMIN

CRYPTOTANSHINONE

EPIGALLOCATECHIN-3-GALLATE

GENISTEIN

GINSENOSIDE

GUGGULSTERONE

HESPERIDIN

KIRENOL

PLUMBAGIN

PRIM-O-GLUCOSYLCIMIFUGIN

MADECASSOCIDE

NORISOBOLDINE

RESVERATROL

THYMOQUINONE

TRIPTOLIDE

WITHAFERIN A

Potential Biomolecules from the Natural Sources for the Treatment of Rheumatoid Arthritis: A Detailed Review

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

981-5050-77-X

OCLC:

1344539494