1 option
Triangulation in environmental epidemiology for EPA human health assessments : proceedings of a workshop / Kathryn Z. Guyton [and five others].
- Format:
- Book
- Author/Creator:
- Guyton, Kathryn Z., author.
- National Academies of Sciences, Engineering, and Medicine, author.
- Division on Earth and Life Studies, author.
- Board on Environmental Studies and Toxicology, author.
- Language:
- English
- Subjects (All):
- Health attitudes.
- Physical Description:
- 1 online resource (93 pages)
- Edition:
- First edition.
- Place of Publication:
- Washington, DC : National Academies Press, [2022]
- Summary:
- Human health risk assessments provide the basis for public health decision-making and chemical regulation in the United States. Three evidence streams generally support the development of human health risk assessments - epidemiology, toxicology, and mechanistic information. Epidemiologic studies are generally the preferred evidence stream for assessing causal relationships during hazard identification. However, the available studies may be limited in scope, subject to bias, or otherwise inadequate to inform causal inferences. In addition, there are challenges in assessing coherence, validity, and reliability during synthesis of individual epidemiological studies with different designs, which in turn affects conclusions on causation.Triangulation aims to address the challenge of synthesizing evidence from diverse studies with distinct sources of bias. Bias is a systematic error that leads to inaccurate study results. Tools for assessing risk of bias provide a structured list of questions for systematic consideration of different domains (such as confounding, selective reporting, and conflict of interest). These tools also provide a structured framework for identifying potential sources of bias and informing judgments on individual studies. The National Academies of Sciences, Engineering, and Medicine convened a workshop to understand and explore triangulation and opportunities to use the practice to enhance the EPA's human health assessments. The workshop was held virtually on May 9 and 11, 2022. This publication summarizes the key presentations and discussions conducted during the workshop.
- Contents:
- Intro
- TITLE PAGE
- COPYRIGHT PAGE
- TABLE OF CONTENTS
- 1 INTRODUCTION
- 2 TRIANGULATION: BACKGROUND, METHODOLOGIES, AND APPLICATIONS
- 3 HEALTH AUTHORITY PERSPECTIVES ON THE SYNTHESIS OF EPIDEMIOLOGIC EVIDENCE
- 4 CASE STUDIES OF TRIANGULATION ACROSS EPIDEMIOLOGY STUDIES FOR HAZARD IDENTIFICATION AND RISK ASSESSMENT
- 5 NEXT STEPS AND OPPORTUNITIES FOR APPLYING TRIANGULATION
- 6 FINAL THOUGHTS AND THE FUTURE OF TRIANGULATION
- REFERENCES
- APPENDIXES
- A WORKSHOP AGENDA
- B SPEAKER AND POSTER PRESENTER BIOGRAPHIES.
- Notes:
- Includes bibliographical references.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9780309686686
- 0309686687
- 9780309686709
- 0309686709
- OCLC:
- 1345588361
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.